Zobrazeno 1 - 10
of 178
pro vyhledávání: '"David A Morilak"'
Autor:
Haven Tillmon, Breeanne M. Soteros, Liang Shen, Qifei Cong, Mackenna Wollet, Julianne General, Hanna Chin, John Beichen Lee, Flavia R. Carreno, David A. Morilak, Jun Hee Kim, Gek Ming Sia
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Spatially heterogeneous synapse loss is a characteristic of many psychiatric and neurological disorders, but the underlying mechanisms are unclear. Here, we show that spatially-restricted complement activation mediates stress-induced heterog
Externí odkaz:
https://doaj.org/article/9c7675651aba4a61b7838ded015dd5df
Autor:
Alexandra M. Vaiana, Yidong Chen, Jonathan Gelfond, Teresa L. Johnson-Pais, Robin J. Leach, Chethan Ramamurthy, Ian M. Thompson, David A. Morilak
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Advances in prostate cancer treatment have significantly improved survival, but quality of life for survivors remains an under-studied area of research. Androgen deprivation therapy (ADT) is a foundational treatment for advanced prostate can
Externí odkaz:
https://doaj.org/article/8d6495592ceb4518a1303cb15fdd755c
Publikováno v:
Neurobiology of Stress, Vol 19, Iss , Pp 100468- (2022)
Post-traumatic stress disorder (PTSD) is a debilitating illness characterized by dysfunction in the medial prefrontal cortex (mPFC). Although both pharmacological and cognitive behavioral interventions have shown some promise at alleviating symptoms,
Externí odkaz:
https://doaj.org/article/5b518dd5ab034e94bb84110d69b03795
451 Interactions between tumor, age, and chemotherapy in cognitive impairments and neuroinflammation
Autor:
Amber M. Asher, David A. Morilak
Publikováno v:
Journal of Clinical and Translational Science, Vol 7, Pp 134-134 (2023)
OBJECTIVES/GOALS: We will use a novel syngeneic model of prostate cancer to examine impairments and uncover potential changes in inflammatory signaling in the brains of animals with and without tumors. We will then investigate the interaction between
Externí odkaz:
https://doaj.org/article/e8751001241a4715b608e891d03959cf
Publikováno v:
Neurobiology of Stress, Vol 13, Iss , Pp 100258- (2020)
Cognitive flexibility is a higher-order executive function that requires plasticity in neuronal circuits of the prefrontal cortex. Deficits in cognitive flexibility are prominent in a variety of psychiatric disorders, such as major depression, obsess
Externí odkaz:
https://doaj.org/article/e70badb895bc4f72ac015ace868f6327
Autor:
Denisse Paredes, David A. Morilak
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 13 (2019)
The symptoms of post-traumatic stress disorder (PTSD) include cognitive impairment related to medial prefrontal cortical dysfunction. Indeed, a deficit of cognitive flexibility, i.e., an inability to modify previously learned thoughts and behaviors b
Externí odkaz:
https://doaj.org/article/8804ae99eed140b6a8c5d28702d43422
Publikováno v:
The international journal of neuropsychopharmacology.
Background Deficits in motor impulsivity, that is, the inability to inhibit a prepotent response, are frequently observed in psychiatric conditions. Several studies suggest that stress often correlates with higher impulsivity. Among the brain areas a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b2d70b70fd672f9785eb7323050ff4b
https://pubmed.ncbi.nlm.nih.gov/36087292
https://pubmed.ncbi.nlm.nih.gov/36087292
Publikováno v:
Neuropsychopharmacology
Current pharmacotherapies for posttraumatic stress disorder (PTSD) and major depressive disorder (MDD) are ineffective for many patients, and often do not restore cognitive dysfunction associated with these disorders. Behavioral therapies, such as ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c47f7fed57b3fb9517796dfc5a7b1c0
https://pubmed.ncbi.nlm.nih.gov/34497360
https://pubmed.ncbi.nlm.nih.gov/34497360
Autor:
Ian M. Thompson, Roman Fernandez, David A. Morilak, Alexandra M. Vaiana, Teresa L. Johnson-Pais, Jonathan Gelfond, Chethan Ramamurthy, Robin J. Leach
Publikováno v:
Cancer Research. 81:2560-2560
Androgen deprivation therapy (ADT) is a frontline treatment for prostate cancer but induces profound cognitive impairment in more than half of patients. This significantly reduces quality of life for cancer survivors and their families. Deficits occu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e145b90ccb12424f8a2da8e8c62ecf1
https://doi.org/10.1158/1538-7445.am2021-2560
https://doi.org/10.1158/1538-7445.am2021-2560
Publikováno v:
International Journal of Neuropsychopharmacology
Background Individuals with stress-related psychiatric disorders exhibit deficits in cognitive flexibility. We have shown that chronic intermittent cold stress induces deficits in reversal learning, a form of cognitive flexibility mediated in the orb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbe8a95cde4a3a4a4ec0cdac8cdf81c2
https://doi.org/10.1093/ijnp/pyy080
https://doi.org/10.1093/ijnp/pyy080