Zobrazeno 1 - 10
of 139
pro vyhledávání: '"David A MacLeod"'
Autor:
Birgit Stallmeyer, Clara Bühlmann, Rytis Stakaitis, Ann-Kristin Dicke, Farah Ghieh, Luisa Meier, Ansgar Zoch, David MacKenzie MacLeod, Johanna Steingröver, Özlem Okutman, Daniela Fietz, Adrian Pilatz, Antoni Riera-Escamilla, Miguel J. Xavier, Christian Ruckert, Sara Di Persio, Nina Neuhaus, Ali Sami Gurbuz, Ahmet Şalvarci, Nicolas Le May, Kevin McEleny, Corinna Friedrich, Godfried van der Heijden, Margot J. Wyrwoll, Sabine Kliesch, Joris A. Veltman, Csilla Krausz, Stéphane Viville, Donald F. Conrad, Dónal O’Carroll, Frank Tüttelmann
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract piRNAs are crucial for transposon silencing, germ cell maturation, and fertility in male mice. Here, we report on the genetic landscape of piRNA dysfunction in humans and present 39 infertile men carrying biallelic variants in 14 different p
Externí odkaz:
https://doaj.org/article/f298226160c54693a03e5498d577cfea
Autor:
Jonathan Steinke, Berta Ortiz-Crespo, Jacob van Etten, Gareth Denis Borman, Mohammed Hassena, Marlene Kretschmer, David A. MacLeod, Dean Muungani
Publikováno v:
Climate Services, Vol 32, Iss , Pp 100410- (2023)
To cope with interannual climate variability, many farmers in tropical and sub-tropical regions choose crop varieties that fit seasonal climate conditions. Therefore, seed demand for different varieties, such as early- or late-maturing cultivars, var
Externí odkaz:
https://doaj.org/article/7b45224a7fe24d6da6ded6f627758740
Autor:
Victoria M. H. Deman, Akash Koppa, Willem Waegeman, David A. MacLeod, Michael Bliss Singer, Diego G. Miralles
Publikováno v:
Frontiers in Water, Vol 4 (2022)
The Horn of Africa is highly vulnerable to droughts and floods, and reliable long-term forecasting is a key part of building resilience. However, the prediction of the “long rains” season (March–May) is particularly challenging for dynamical cl
Externí odkaz:
https://doaj.org/article/43b8def85f424323ad68a4941fa2d082
Autor:
Stephen J. Dollery, Daniel V. Zurawski, Ruth V. Bushnell, John K. Tobin, Taralyn J. Wiggins, David A. MacLeod, Naomi J. P. E. R. Tasker, Yonas A. Alamneh, Rania Abu-Taleb, Christine M. Czintos, Wanwen Su, Mariel G. Escatte, Heather N. Meeks, Michael J. Daly, Gregory J. Tobin
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Acinetobacter baumannii causes multi-system diseases in both nosocomial settings and a pre-disposed general population. The bacterium is not only desiccation-resistant but also notoriously resistant to multiple antibiotics and drugs of last resort in
Externí odkaz:
https://doaj.org/article/2b5beb2fdae144e2bb17c3993faa5ce1
Autor:
Greg S. Martin, David A. Kaufman, Paul E. Marik, Nathan I. Shapiro, Denny Z. H. Levett, John Whittle, David B. MacLeod, Desiree Chappell, Jonathan Lacey, Tom Woodcock, Kay Mitchell, Manu L. N. G. Malbrain, Tom M. Woodcock, Daniel Martin, Chris H. E. Imray, Michael W. Manning, Henry Howe, Michael P. W. Grocott, Monty G. Mythen, Tong J. Gan, Timothy E. Miller
Publikováno v:
Perioperative Medicine, Vol 9, Iss 1, Pp 1-12 (2020)
Abstract Background Optimal fluid therapy in the perioperative and critical care settings depends on understanding the underlying cardiovascular physiology and individualizing assessment of the dynamic patient state. Methods The Perioperative Quality
Externí odkaz:
https://doaj.org/article/05b8a6c2162e4e63acba9662dadc823b
Autor:
Stephen J. Dollery, Janette M. Harro, Taralyn J. Wiggins, Brendan P. Wille, Peter C. Kim, John K. Tobin, Ruth V. Bushnell, Naomi J. P. E. R. Tasker, David A. MacLeod, Gregory J. Tobin
Publikováno v:
Vaccines, Vol 10, Iss 6, p 833 (2022)
Many microbes of concern to human health remain without vaccines. We have developed a whole-microbe inactivation technology that enables us to rapidly inactivate large quantities of a pathogen while retaining epitopes that were destroyed by previous
Externí odkaz:
https://doaj.org/article/a10dfb6456f24fdfb13f1dc0daf63ee1
Autor:
Jay MJR Carr, Philip N Ainslie, David B MacLeod, Joshua C Tremblay, Daniela Nowak-Flück, Connor A Howe, Mike Stembridge, Alexander Patrician, Geoff B Coombs, Benjamin S Stacey, Damian M Bailey, Daniel J Green, Ryan L Hoiland
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 43:99-114
This study investigated the influence of acute reductions in arterial O2 content (CaO2) via isovolumic haemodilution on global cerebral blood flow (gCBF) and cerebrovascular CO2 reactivity (CVR) in 11 healthy males (age; 28 ± 7 years: body mass inde
Autor:
Stephen J. Dollery, Daniel V. Zurawski, Elena K. Gaidamakova, Vera Y. Matrosova, John K. Tobin, Taralyn J. Wiggins, Ruth V. Bushnell, David A. MacLeod, Yonas A. Alamneh, Rania Abu-Taleb, Mariel G. Escatte, Heather N. Meeks, Michael J. Daly, Gregory J. Tobin
Publikováno v:
Vaccines, Vol 9, Iss 2, p 96 (2021)
Acinetobacter baumannii is a bacterial pathogen that is often multidrug-resistant (MDR) and causes a range of life-threatening illnesses, including pneumonia, septicemia, and wound infections. Some antibiotic treatments can reduce mortality if dosed
Externí odkaz:
https://doaj.org/article/975d9d8c0a5940009a01e2707c28e8ae
Autor:
Hannah G Caldwell, Ryan L Hoiland, Kurt J Smith, Patrice Brassard, Anthony R Bain, Michael M Tymko, Connor A Howe, Jay MJR Carr, Benjamin S Stacey, Damian M Bailey, Audrey Drapeau, Mypinder S Sekhon, David B MacLeod, Philip N Ainslie
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 42:559-571
This study investigated trans-cerebral internal jugular venous-arterial bicarbonate ([HCO3−]) and carbon dioxide tension (PCO2) exchange utilizing two separate interventions to induce acidosis: 1) acute respiratory acidosis via elevations in arteri
Autor:
Rachel Stone, David B. MacLeod, Philip N. Ainslie, John D. Akins, Michael M. Tymko, Anthony R Bain, Joshua C. Tremblay, Christopher A. DeSouza
Publikováno v:
The Journal of Physiology. 600:1373-1383
Key points Vascular dysfunction has been demonstrated in lowlanders at high-altitude (>4,000 m), however the extent of impairment and the delineation of contributing mechanisms have remained unclear. Using the gold-standard isolated perfused forearm