Zobrazeno 1 - 10
of 551
pro vyhledávání: '"David A Jans"'
Publikováno v:
Cell & Bioscience, Vol 14, Iss 1, Pp 1-22 (2024)
Abstract Background The glycolytic enzyme alpha-enolase is a known biomarker of many cancers and involved in tumorigenic functions unrelated to its key role in glycolysis. Here, we show that expression of alpha-enolase correlates with subcellular loc
Externí odkaz:
https://doaj.org/article/ebc6ef5325644d92b45ceca6d5fe45d8
Autor:
MengJie Hu, Keith E Schulze, Reena Ghildyal, Darren C Henstridge, Jacek L Kolanowski, Elizabeth J New, Yuning Hong, Alan C Hsu, Philip M Hansbro, Peter AB Wark, Marie A Bogoyevitch, David A Jans
Publikováno v:
eLife, Vol 8 (2019)
Although respiratory syncytial virus (RSV) is responsible for more human deaths each year than influenza, its pathogenic mechanisms are poorly understood. Here high-resolution quantitative imaging, bioenergetics measurements and mitochondrial membran
Externí odkaz:
https://doaj.org/article/c0881d4026df4c5a830306c47e5b4488
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0170576 (2017)
Fetal germ cell development is tightly regulated by the somatic cell environment, and is characterised by cell cycle states that differ between XY and XX gonads. In the testis, gonocytes enter G1/G0 arrest from 12.5 days post coitum (dpc) in mice and
Externí odkaz:
https://doaj.org/article/ae72dcc3b78d434eb6c7e66dd13b8499
Autor:
Lindsay Lundberg, Chelsea Pinkham, Cynthia de la Fuente, Ashwini Brahms, Nazly Shafagati, Kylie M Wagstaff, David A Jans, Sharon Tamir, Kylene Kehn-Hall
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 10, Iss 11, p e0005122 (2016)
The capsid structural protein of the New World alphavirus, Venezuelan equine encephalitis virus (VEEV), interacts with the host nuclear transport proteins importin α/β1 and CRM1. Novel selective inhibitor of nuclear export (SINE) compounds, KPT-185
Externí odkaz:
https://doaj.org/article/6ee7079ab4dd440c80b3aad825d36fab
Autor:
Moon Y F Tay, Kate Smith, Ivan H W Ng, Kitti W K Chan, Yongqian Zhao, Eng Eong Ooi, Julien Lescar, Dahai Luo, David A Jans, Jade K Forwood, Subhash G Vasudevan
Publikováno v:
PLoS Pathogens, Vol 12, Iss 9, p e1005886 (2016)
Dengue virus NS5 is the most highly conserved amongst the viral non-structural proteins and is responsible for capping, methylation and replication of the flavivirus RNA genome. Interactions of NS5 with host proteins also modulate host immune respons
Externí odkaz:
https://doaj.org/article/9e9c108301bf452ba39968dbcd11a832
Autor:
Caitlin L Rowe, Kylie M Wagstaff, Sibil Oksayan, Dominic J Glover, David A Jans, Gregory W Moseley
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0150477 (2016)
Rabies virus P-protein is expressed as five isoforms (P1-P5) which undergo nucleocytoplasmic trafficking important to roles in immune evasion. Although nuclear import of P3 is known to be mediated by an importin (IMP)-recognised nuclear localization
Externí odkaz:
https://doaj.org/article/48ad38990119400d922b6cdb47952645
LRGUK-1 is required for basal body and manchette function during spermatogenesis and male fertility.
Autor:
Yan Liu, Kathleen DeBoer, David M de Kretser, Liza O'Donnell, Anne E O'Connor, D Jo Merriner, Hidenobu Okuda, Belinda Whittle, David A Jans, Athina Efthymiadis, Robert I McLachlan, Christopher J Ormandy, Chris C Goodnow, Duangporn Jamsai, Moira K O'Bryan
Publikováno v:
PLoS Genetics, Vol 11, Iss 3, p e1005090 (2015)
Male infertility affects at least 5% of reproductive age males. The most common pathology is a complex presentation of decreased sperm output and abnormal sperm shape and motility referred to as oligoasthenoteratospermia (OAT). For the majority of OA
Externí odkaz:
https://doaj.org/article/040121e1c3374ed8a427d065623bd48c
Autor:
Alejandra Vásquez-Limeta, Kylie M Wagstaff, Arturo Ortega, Dorothy H Crouch, David A Jans, Bulmaro Cisneros
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e90629 (2014)
The β-dystroglycan (β-DG) protein has the ability to target to multiple sites in eukaryotic cells, being a member of diverse protein assemblies including the transmembranal dystrophin-associated complex, and a nuclear envelope-localised complex tha
Externí odkaz:
https://doaj.org/article/7f8c2436cc1b4e2296f85a9f5ce616e9
Autor:
Erin J Walker, Parisa Younessi, Alex J Fulcher, Robert McCuaig, Belinda J Thomas, Philip G Bardin, David A Jans, Reena Ghildyal
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e71316 (2013)
Human Rhinovirus (HRV) infection results in shut down of essential cellular processes, in part through disruption of nucleocytoplasmic transport by cleavage of the nucleoporin proteins (Nups) that make up the host cell nuclear pore. Although the HRV
Externí odkaz:
https://doaj.org/article/627b7df5387e406091a20b34869d192e
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e51466 (2012)
Nullbasic, a mutant of the HIV-1 Tat protein, has anti-HIV-1 activity through mechanisms that include inhibition of Rev function and redistribution of the HIV-1 Rev protein from the nucleolus to the nucleoplasm and cytoplasm. Here we investigate the
Externí odkaz:
https://doaj.org/article/2b1935cdd4aa4ab88b18f0518e0a6c69