Zobrazeno 1 - 10
of 44
pro vyhledávání: '"David A Horita"'
Autor:
Karishma R Rajani, Elizabeth L Pettit Kneller, Margie O McKenzie, David A Horita, Jeff W Chou, Douglas S Lyles
Publikováno v:
PLoS Pathogens, Vol 8, Iss 9, p e1002929 (2012)
Vesicular stomatitis virus (VSV) suppresses antiviral responses in infected cells by inhibiting host gene expression at multiple levels, including transcription, nuclear cytoplasmic transport, and translation. The inhibition of host gene expression i
Externí odkaz:
https://doaj.org/article/dd47a26ab67a448687cbe8c689e4c800
Autor:
Joseph T O'Flaherty, Yungping Hu, Rhonda E Wooten, David A Horita, Michael P Samuel, Michael J Thomas, Haiguo Sun, Iris J Edwards
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45480 (2012)
A 15-LOX, it is proposed, suppresses the growth of prostate cancer in part by converting arachidonic, eicosatrienoic, and/or eicosapentaenoic acids to n-6 hydroxy metabolites. These metabolites inhibit the proliferation of PC3, LNCaP, and DU145 prost
Externí odkaz:
https://doaj.org/article/f38c19b8db4d4e26bfae1cf6f486c568
Autor:
Baharan Fekry, Kristen A. Jeffries, Amin Esmaeilniakooshkghazi, Zdzislaw M. Szulc, Kevin J. Knagge, David R. Kirchner, David A. Horita, Sergey A. Krupenko, Natalia I. Krupenko
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Ceramides are important participants of signal transduction, regulating fundamental cellular processes. Here authors show that C16-ceramide binds to the tumor suppressor p53, disrupts its interaction with MDM2 and facilitates p53 accumulation and act
Externí odkaz:
https://doaj.org/article/c8bb01b97ed94da88a335f1f599d147e
Autor:
Steven H. Zeisel, David R. Kirchner, Julie M. Stegall, Walter B. Friday, David A. Horita, Sunil Hwang
Publikováno v:
Am J Clin Nutr
BACKGROUND: Choline deficiency has numerous negative health consequences; although the preponderance of the US population consumes less than the recommended Adequate Intake (AI), clinical assessment of choline status is difficult. Further, several pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::453f49b87b00217224457712302d7aa3
https://pubmed.ncbi.nlm.nih.gov/33668062
https://pubmed.ncbi.nlm.nih.gov/33668062
Autor:
David A. Horita, Sergey A. Krupenko
Publikováno v:
Chemico-Biological Interactions. 276:23-30
ALDH1L1, a member of the aldehyde dehydrogenase superfamily of enzymes, catalyzes the conversion of 10-formyltetrahydrofolate to tetrahydrofolate and CO2. The enzyme is a tetramer of identical subunits, with each subunit consisting of three functiona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60361fdcdb865671e02c54074cee886e
https://doi.org/10.1016/j.cbi.2017.04.011
https://doi.org/10.1016/j.cbi.2017.04.011
Autor:
Sergey A. Krupenko, David A. Horita
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
Frontiers in Genetics
Frontiers in Genetics
Folate (vitamin B9) is a common name for a group of coenzymes that function as carriers of chemical moieties called one-carbon groups in numerous biochemical reactions. The combination of these folate-dependent reactions constitutes one-carbon metabo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ada9294f3c33cd36370b582f17a4e2b8
https://doi.org/10.3389/fgene.2019.01013
https://doi.org/10.3389/fgene.2019.01013
Autor:
Natalia I. Krupenko, Sergey A. Krupenko, Kevin J. Knagge, David R. Kirchner, Baharan Fekry, Zdzislaw M. Szulc, Amin Esmaeilniakooshkghazi, David A. Horita, Kristen A. Jeffries
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Ceramides are important participants of signal transduction, regulating fundamental cellular processes. Here we report the mechanism for activation of p53 tumor suppressor by C16-ceramide. C16-ceramide tightly binds within the p53 DNA-binding domain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01cc9cce6caac7d83c816d16b00ff415
https://doi.org/10.1038/s41467-018-06650-y
https://doi.org/10.1038/s41467-018-06650-y
Autor:
Derek Parsonage, Frank M. Torti, Suzy V. Torti, David A. Horita, Thomas Hollis, Annissa J. Huhn
Publikováno v:
Protein Science. 23:1013-1022
High-molecular-weight kininogen domain 5 (HK5) is an angiogenic modulator that is capable of inhibiting endothelial cell proliferation, migration, adhesion, and tube formation. Ferritin can bind to a histidine–glycine–lysine-rich region within HK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62846691db781d76cbe4be72f2d1d1a8
https://doi.org/10.1002/pro.2486
https://doi.org/10.1002/pro.2486
Autor:
Christopher H. Stuart, David A. Horita, Michael J. Thomas, Freddie R. Salsbury, Mark O. Lively, William H. Gmeiner
Publikováno v:
Bioconjugate Chemistry
Doxorubicin (Dox) is widely used for breast cancer treatment but causes serious side- effects including cardiotoxicity that may adversely impact patient lifespan even if treatment is successful. The present invention relates to selective conjugation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09fe215df77270e8221e32bccd3eaae6
https://doi.org/10.1021/bc4005427
https://doi.org/10.1021/bc4005427
Autor:
Gale A. Kleven, John Olson, April E. Ronca, David A. Horita, Christina D. Tulbert, Jonathan J. Morgan
Publikováno v:
NMR in Biomedicine. 26:683-691
The present study represents the first longitudinal, within-subject 1H MRS investigation of the developing rat brain spanning infancy, adolescence, and early adulthood. We obtained neurometabolite profiles from a voxel located in a central location o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::592abd774a074e22ab715f8047ccf7f6
https://doi.org/10.1002/nbm.2913
https://doi.org/10.1002/nbm.2913