CD4+ T cell cytokine responses to the DAR-901 booster vaccine in BCG-primed adults: A randomized, placebo-controlled trial.

Autor: Tereza Masonou, David A Hokey, Timothy Lahey, Alice Halliday, Luis C Berrocal-Almanza, Wendy F Wieland-Alter, Robert D Arbeit, Ajit Lalvani, C Fordham von Reyn

Publikováno v: PLoS ONE, Vol 14, Iss 5, p e0217091 (2019)

BACKGROUND:DAR-901 is an inactivated whole cell tuberculosis booster vaccine, prepared using a new scalable, broth-grown method from the master cell bank of SRL172, a vaccine previously shown to prevent tuberculosis. This study examined whether DAR-9

Externí odkaz: https://doaj.org/article/88ddceddb42140d889ed399b458a473e

A Phase I, Open-Label Trial, Evaluating the Safety and Immunogenicity of Candidate Tuberculosis Vaccines AERAS-402 and MVA85A, Administered by Prime-Boost Regime in BCG-Vaccinated Healthy Adults.

Autor: Sharon Sheehan, Stephanie A Harris, Iman Satti, David A Hokey, Veerabadran Dheenadhayalan, Lisa Stockdale, Zita-Rose Manjaly Thomas, Alice Minhinnick, Morven Wilkie, Samantha Vermaak, Joel Meyer, Matthew K O'Shea, Maria Grazia Pau, Isabella Versteege, Macaya Douoguih, Jenny Hendriks, Jerald Sadoff, Bernard Landry, Paul Moss, Helen McShane

Publikováno v: PLoS ONE, Vol 10, Iss 11, p e0141687 (2015)

MVA85A and AERAS-402 are two clinically advanced viral vectored TB vaccine candidates expressing Mycobacterium tuberculosis antigens designed to boost BCG-induced immunity. Clinical trials with candidate malaria vaccines have demonstrated that adenov

Externí odkaz: https://doaj.org/article/5b7a79c4e6d34056983f405b41737c6f

Immune modulation through 4-1BB enhances SIV vaccine protection in non-human primates against SIVmac251 challenge.

Autor: Lauren A Hirao, David A Hokey, Matthew P Morrow, Maria N Jure-Kunkel, David B Weiner

Publikováno v: PLoS ONE, Vol 6, Iss 9, p e24250 (2011)

Costimulatory molecules play a central role in the development of cellular immunity. Understanding how costimulatory pathways can be directed to positively influence the immune response may be critical for the generation of an effective HIV vaccine.

Externí odkaz: https://doaj.org/article/77d1fcd4df1a4d00949221dd3f4bd163

Multidimensional analyses reveal modulation of adaptive and innate immune subsets by tuberculosis vaccines

Autor: Ann M. Ginsberg, Thomas J. Scriba, Mark Hatherill, Carlos A. DiazGranados, William Fulp, Mzwandile Erasmus, Greg Finak, C Study Team, Hennie Geldenhuys, Sanjay Gurunathan, Asma Toefy, Munyaradzi Musvosvi, Linda-Gail Bekker, Muki Shey, Virginie Rozot, Nicole Bilek, David A. Hokey, Frances Rantangee, Lebohang Makhethe, Simbarashe Mabwe, Elisa Nemes

Publikováno v: Communications Biology
Communications Biology, Vol 3, Iss 1, Pp 1-12 (2020)

We characterize the breadth, function and phenotype of innate and adaptive cellular responses in a prevention of Mycobacterium tuberculosis infection trial. Responses are measured by whole blood intracellular cytokine staining at baseline and 70 days

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::428d4dd19affe5e05841a082527aab1d
https://doi.org/10.1038/s42003-020-01288-3

CD4+ T cell cytokine responses to the DAR-901 booster vaccine in BCG-primed adults: A randomized, placebo-controlled trial

Autor: Wendy Wieland-Alter, Luis C Berrocal-Almanza, Alice Halliday, Tereza Masonou, Ajit Lalvani, C. Fordham von Reyn, Timothy Lahey, Robert D. Arbeit, David A. Hokey

Publikováno v: Masonou, T, Hokey, D A, Lahey, T, Halliday, A, Berrocal-Almanza, L C, Wieland-Alter, W F, Arbeit, R D, Lalvani, A & von Reyn, C F 2019, ' CD4+ T cell cytokine responses to the DAR-901 booster vaccine in BCG-primed adults : A randomized, placebo-controlled trial ', PLoS ONE, vol. 14, no. 5, e0217091 . https://doi.org/10.1371/journal.pone.0217091
PLoS ONE
PLoS ONE, Vol 14, Iss 5, p e0217091 (2019)

Background DAR-901 is an inactivated whole cell tuberculosis booster vaccine, prepared using a new scalable, broth-grown method from the master cell bank of SRL172, a vaccine previously shown to prevent tuberculosis. This study examined whether DAR-9

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a6039b92de414116bca08f80327bc76
http://hdl.handle.net/10044/1/70427