Zobrazeno 1 - 10
of 1 337
pro vyhledávání: '"David A Gordon"'
Autor:
Joshua G. Dubowsky, Binoy Appukuttan, Evangeline Cowell, Valeria Sanders, David L. Gordon, Jillian M. Carr
Publikováno v:
Exploration of Immunology, Vol 4, Iss 3, Pp 376-393 (2024)
Aim: Severe dengue is correlated with a decrease in the circulating complement regulator, factor H (FH) and prior work has shown that dengue virus (DENV) infection induces FH mRNA but not FH protein release. Here, the mechanisms of this phenomenon we
Externí odkaz:
https://doaj.org/article/d24b43a508b04a51afea0962ba1905e2
Autor:
Oday Salman, Lei Zhao, Jordana B. Cohen, Marie Joe Dib, Joe David Azzo, Sushrima Gan, A. Mark Richards, Bianca Pourmussa, Rob Doughty, Ali Javaheri, Douglas L. Mann, Ernst Rietzschel, Manyun Zhao, Zhaoqing Wang, Christina Ebert, Vanessa van Empel, Karl Kammerhoff, Joseph Maranville, Joseph Gogain, Jaclyn Dennis, Peter H. Schafer, Dietmar Seiffert, David A. Gordon, Francisco Ramirez‐Valle, Thomas P. Cappola, Julio A. Chirinos
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 17 (2024)
Background Kidney disease is common in heart failure with preserved ejection fraction (HFpEF). However, the biologic correlates and prognostic significance of kidney injury (KI), in HFpEF, beyond the estimated glomerular filtration rate (eGFR), are u
Externí odkaz:
https://doaj.org/article/005acfdc8a4844deafa49b506123ac19
Autor:
Oday Salman, Payman Zamani, Lei Zhao, Marie Joe Dib, Sushrima Gan, Joe David Azzo, Bianca Pourmussa, Arthur Mark Richards, Ali Javaheri, Douglas L. Mann, Ernst Rietzschel, Manyun Zhao, Zhaoqing Wang, Christina Ebert, Laura Liu, Kushan L. Gunawardhana, Danielle Greenawalt, Leon Carayannopoulos, Ching‐Pin Chang, Vanessa van Empel, Joseph Gogain, Peter H. Schafer, David A. Gordon, Francisco Ramirez‐Valle, Thomas P. Cappola, Julio A. Chirinos
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 17 (2024)
Background The role of cellular senescence in human heart failure (HF) remains unclear. The senescence‐associated secretory phenotype (SASP) is composed of proteins released by senescent cells. We assessed the prognostic significance and biologic p
Externí odkaz:
https://doaj.org/article/9ce69a1294c446d9a935a66c5df06d36
Autor:
Samrat Sahu, Benjamin Emenike, Christian Michel Beusch, Pritha Bagchi, David Ezra Gordon, Monika Raj
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Methionine plays a critical role in various biological and cell regulatory processes, making its chemoproteomic profiling indispensable for exploring its functions and potential in protein therapeutics. Building on the principle of rapid oxi
Externí odkaz:
https://doaj.org/article/9367a00a29de43b7a5a1b24bbc7b30e5
Autor:
Ricardo A Garcia, Mujing Yan, Debra Search, Rongan Zhang, Nancy L Carson, Carol S Ryan, Constance Smith-Monroy, Joanna Zheng, Jian Chen, Yan Kong, Huaping Tang, Samuel E Hellings, Judith Wardwell-Swanson, Joseph E Dinchuk, George C Psaltis, David A Gordon, Peter W Glunz, Peter S Gargalovic
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e111385 (2014)
BACKGROUND: P2Y(6), a purinergic receptor for UDP, is enriched in atherosclerotic lesions and is implicated in pro-inflammatory responses of key vascular cell types and macrophages. Evidence for its involvement in atherogenesis, however, has been lac
Externí odkaz:
https://doaj.org/article/226e843b35fe4bc7b87247e99442f01e
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
Novel therapeutic approaches are needed for the treatment of Ewing sarcoma tumors. We previously identified that Ewing sarcoma cell lines are sensitive to drugs that inhibit protein translation. However, translational and therapeutic approaches to in
Externí odkaz:
https://doaj.org/article/7f37a116e14143109f12ef468ee9eca5
Autor:
Legesse Garedew Kifelew, Morgyn S. Warner, Sandra Morales, David L. Gordon, Nicky Thomas, James G. Mitchell, Peter G. Speck
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Complications of diabetes, such as diabetic foot ulcers (DFUs), are common, multifactorial in origin, and costly to treat. DFUs are the cause of nearly 90% of limb amputations among persons with diabetes. In most chronic infections such as D
Externí odkaz:
https://doaj.org/article/5050fe918ace48169c8715d8007e0510
Autor:
Ricardo A García, Debra J Search, John A Lupisella, Jacek Ostrowski, Bo Guan, Jian Chen, Wen-Pin Yang, Amy Truong, Aiqing He, Rongan Zhang, Mujing Yan, Samuel E Hellings, Peter S Gargalovic, Carol S Ryan, Linda M Watson, Robert A Langish, Petia A Shipkova, Nancy L Carson, Joseph R Taylor, Richard Yang, George C Psaltis, Thomas W Harrity, Jeffrey A Robl, David A Gordon
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e53192 (2013)
BACKGROUND: Chronic glucocorticoid excess has been linked to increased atherosclerosis and general cardiovascular risk in humans. The enzyme 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) increases active glucocorticoid levels within tissues by
Externí odkaz:
https://doaj.org/article/6bd68584051f4497b56fefb3bbb8522c
Autor:
Corinne Carland, Lei Zhao, Oday Salman, Jordana B. Cohen, Payman Zamani, Qing Xiao, Ashok Dongre, Zhaoqing Wang, Christina Ebert, Danielle Greenawalt, Vanessa van Empel, A. Mark Richards, Robert N. Doughty, Ernst Rietzschel, Ali Javaheri, Yixin Wang, Peter H. Schafer, Sarah Hersey, Leonidas N. Carayannopoulos, Dietmar Seiffert, Ching‐Pin Chang, David A. Gordon, Francisco Ramirez‐Valle, Douglas L. Mann, Thomas P. Cappola, Julio A. Chirinos
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 9 (2024)
Background Although several studies have addressed plasma proteomics in heart failure with preserved ejection fraction, limited data are available on the prognostic value of urinary proteomics. The objective of our study was to identify urinary prote
Externí odkaz:
https://doaj.org/article/31d03371ea994940952d131d3a850e78
Autor:
Marie‐Joe Dib, Michael G. Levin, Lei Zhao, Ahmed Diab, Zhaoqing Wang, Christina Ebert, Oday Salman, Joe David Azzo, Sushrima Gan, Payman Zamani, Jordana B. Cohen, Dipender Gill, Stephen Burgess, Loukas Zagkos, Vanessa van Empel, A. Mark Richards, Rob Doughty, Ernst R. Rietzschel, Karl Kammerhoff, Erika Kvikstad, Joseph Maranville, Peter Schafer, Dietmar A. Seiffert, Francisco Ramirez‐Valle, David A. Gordon, Ching‐Pin Chang, Ali Javaheri, Douglas L. Mann, Thomas P. Cappola, Julio A. Chirinos
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 5 (2024)
Background Identifying novel molecular drivers of disease progression in heart failure (HF) is a high‐priority goal that may provide new therapeutic targets to improve patient outcomes. The authors investigated the relationship between plasma prote
Externí odkaz:
https://doaj.org/article/5a885cf45ed64ca0bb38fb1fc18ac373