Zobrazeno 1 - 10
of 177
pro vyhledávání: '"David A Dorward"'
Autor:
Richard O’Connor, David A Dorward, Ahsan R Akram, Lilian Koppensteiner, Layla Mathieson, Samuel Pattle
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 8 (2023)
Purpose An improved mechanistic understanding of immunosuppressive pathways in non-small cell lung cancer (NSCLC) is important to develop novel diagnostic and therapeutic approaches. Here, we investigate the prognostic significance of the ectonucleot
Externí odkaz:
https://doaj.org/article/aa9f797358354e38a4f06c44b000a342
Autor:
Stuart Astbury, Jane I Grove, David A Dorward, Indra N Guha, Jonathan A Fallowfield, Timothy J Kendall
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 7, Iss 5, Pp 471-481 (2021)
Abstract Biopsy remains the gold‐standard measure for staging liver disease, both to inform prognosis and to assess the response to a given treatment. Semiquantitative scores such as the Ishak fibrosis score are used for evaluation. These scores ar
Externí odkaz:
https://doaj.org/article/26ed8a88a22d4260a6d1f9a5f383f1ce
Autor:
Richard A O’Connor, Vishwani Chauhan, Layla Mathieson, Helen Titmarsh, Lilian Koppensteiner, Irene Young, Giulia Tagliavini, David A Dorward, Sandrine Prost, Kevin Dhaliwal, William A Wallace, Ahsan R Akram
Publikováno v:
OncoImmunology, Vol 10, Iss 1 (2021)
The success of immune checkpoint therapy shows tumor-reactive T cells can eliminate cancer cells but are restrained by immunosuppression within the tumor micro-environment (TME). Cancer associated fibroblasts (CAFs) are the dominant stromal cell in t
Externí odkaz:
https://doaj.org/article/19838a453ec645a38a6c1e2f5e15aeb8
Autor:
Elspeth J Hulse, Sionagh H Smith, William A Wallace, David A Dorward, A John Simpson, Gordon Drummond, Richard E Clutton, Michael Eddleston
Publikováno v:
PLoS ONE, Vol 15, Iss 10, p e0240563 (2020)
Organophosphorus (OP) insecticide self-poisoning causes over 100,000 global deaths annually. Around a third of patients are intubated and up to half of these can die. Post-mortem analysis of OP poisoned patients' lungs reveals consolidation, edema an
Externí odkaz:
https://doaj.org/article/31fcc4b9271b4aa5be161e9770e594ab
Autor:
Ana L Alessandri, Rodger Duffin, Andrew E Leitch, Christopher D Lucas, Tara A Sheldrake, David A Dorward, Nik Hirani, Vanessa Pinho, Lirlândia Pires de Sousa, Mauro M Teixeira, John F Lyons, Christopher Haslett, Adriano G Rossi
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e25683 (2011)
Eosinophils not only defend the body against parasitic infection but are also involved in pathological inflammatory allergic diseases such as asthma, allergic rhinitis and contact dermatitis. Clearance of apoptotic eosinophils by macrophages is a key
Externí odkaz:
https://doaj.org/article/c1a3b7d4cbea493cac69e41a520b8a9c
Autor:
Jaclyn A. Kaiser, Xueqiao Liu, Cindy Luongo, Yumiko Matsuoka, Celia Santos, Lijuan Yang, Richard Herbert, Ashley Castens, David W. Dorward, Reed F. Johnson, Hong-Su Park, Sharmin Afroz, Shirin Munir, Cyril Le Nouën, Ursula J. Buchholz
Publikováno v:
iScience, Vol 26, Iss 12, Pp 108490- (2023)
Summary: Next-generation SARS-CoV-2 vaccines are needed that induce systemic and mucosal immunity. Murine pneumonia virus (MPV), a murine homolog of respiratory syncytial virus, is attenuated by host-range restriction in nonhuman primates and has a t
Externí odkaz:
https://doaj.org/article/cbf4d88789d345baa457b5b0e0bb1922
Autor:
Helen F. Titmarsh, Alex von Kriegsheim, Jimi C. Wills, Richard A. O’Connor, Kevin Dhaliwal, Margaret C. Frame, Samuel B. Pattle, David A. Dorward, Adam Byron, Ahsan R. Akram
Publikováno v:
Titmarsh, H F, Von Kriegsheim, A, Wills, J C, O'Connor, R A, Dhaliwal, K, Frame, M C, Pattle, S B, Dorward, D A, Byron, A & Akram, A R 2023, ' Quantitative proteomics identifies tumour matrisome signatures in patients with non-small cell lung cancer ', Frontiers in Oncology, vol. 13 . https://doi.org/10.3389/fonc.2023.1194515
The composition and remodelling of the extracellular matrix (ECM) are important factors in the development and progression of cancers, and the ECM is implicated in promoting tumour growth and restricting anti-tumour therapies through multiple mechani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8df6b55b9af2f367854f40dc2043890
https://research.manchester.ac.uk/en/publications/2d8e7666-8e4c-474a-8e48-e7df086e22d5
https://research.manchester.ac.uk/en/publications/2d8e7666-8e4c-474a-8e48-e7df086e22d5
Autor:
Jenny Wachter, Britney Cheff, Chad Hillman, Valentina Carracoi, David W. Dorward, Craig Martens, Kent Barbian, Glenn Nardone, L. Renee Olano, Margie Kinnersley, Patrick R. Secor, Patricia A. Rosa
Publikováno v:
Nature Communications. 14
The alternative sigma factor RpoS plays a central role in the critical host-adaptive response of the Lyme disease spirochete, Borrelia burgdorferi. We previously identified bbd18 as a negative regulator of RpoS but could not inactivate bbd18 in wild-
Autor:
Lilian Koppensteiner, Layla Mathieson, Samuel Pattle, David A Dorward, Richard O’Connor, Ahsan Akram
An improved mechanistic understanding of immunosuppressive pathways in NSCLC is important to develop novel diagnostic and therapeutic approaches. Here, we reveal that the prognostic significance of the rate limiting ectonucleotidases in adenosine pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0867e71f47b5dfd6ebabc3dd960ae431
https://doi.org/10.1101/2022.09.29.509921
https://doi.org/10.1101/2022.09.29.509921
Autor:
Asta Valančiūtė, Layla Mathieson, Richard A. O’Connor, Jamie I. Scott, Marc Vendrell, David A. Dorward, Ahsan R. Akram, Kevin Dhaliwal
Publikováno v:
Cancers; Volume 14; Issue 17; Pages: 4119
Valančiūtė, A, Mathieson, L, O'Connor, R A, Scott, J I, Vendrell, M, Dorward, D A, Akram, A R & Dhaliwal, K 2022, ' Phototherapeutic Induction of Immunogenic Cell Death and CD8+ T Cell-Granzyme B Mediated Cytolysis in Human Lung Cancer Cells and Organoids ', Cancers, vol. 14, no. 17, 4119 . https://doi.org/10.3390/cancers14174119
Valančiūtė, A, Mathieson, L, O'Connor, R A, Scott, J I, Vendrell, M, Dorward, D A, Akram, A R & Dhaliwal, K 2022, ' Phototherapeutic Induction of Immunogenic Cell Death and CD8+ T Cell-Granzyme B Mediated Cytolysis in Human Lung Cancer Cells and Organoids ', Cancers, vol. 14, no. 17, 4119 . https://doi.org/10.3390/cancers14174119
Augmenting T cell mediated tumor killing via immunogenic cancer cell death (ICD) is the cornerstone of emerging immunotherapeutic approaches. We investigated the potential of methylene blue photodynamic therapy (MB-PDT) to induce ICD in human lung ca