Výsledky vyhledávání - "David A DiGregorio"

Akademický článek

Developmental emergence of two-stage nonlinear synaptic integration in cerebellar interneurons

Autor: Celia Biane, Florian Rückerl, Therese Abrahamsson, Cécile Saint-Cloment, Jean Mariani, Ryuichi Shigemoto, David A DiGregorio, Rachel M Sherrard, Laurence Cathala

Publikováno v: eLife, Vol 10 (2021)

Synaptic transmission, connectivity, and dendritic morphology mature in parallel during brain development and are often disrupted in neurodevelopmental disorders. Yet how these changes influence the neuronal computations necessary for normal brain fu

Externí odkaz: https://doaj.org/article/e901c6bb1a0b4100a07a29c39d4e8419

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Akademický článek

Feed-forward recruitment of electrical synapses enhances synchronous spiking in the mouse cerebellar cortex

Autor: Andreas Hoehne, Maureen H McFadden, David A DiGregorio

Publikováno v: eLife, Vol 9 (2020)

In the cerebellar cortex, molecular layer interneurons use chemical and electrical synapses to form subnetworks that fine-tune the spiking output of the cerebellum. Although electrical synapses can entrain activity within neuronal assemblies, their r

Externí odkaz: https://doaj.org/article/b529dee35ece4f67b1ae5332b69f6556

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Akademický článek

Demonstration that sublinear dendrites enable linearly non-separable computations

Autor: Romain D. Cazé, Alexandra Tran-Van-Minh, Boris S. Gutkin, David A. DiGregorio

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)

Abstract Theory predicts that nonlinear summation of synaptic potentials within dendrites allows neurons to perform linearly non-separable computations (LNSCs). Using Boolean analysis approaches, we predicted that both supralinear and sublinear synap

Externí odkaz: https://doaj.org/article/12769a63623441bbb871d8eac70b2034

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Akademický článek

Two-photon compatibility and single-voxel, single-trial detection of subthreshold neuronal activity by a two-component optical voltage sensor.

Autor: Ann E Fink, Kevin J Bender, Laurence O Trussell, Thomas S Otis, David A DiGregorio

Publikováno v: PLoS ONE, Vol 7, Iss 8, p e41434 (2012)

Minimally invasive measurements of neuronal activity are essential for understanding how signal processing is performed by neuronal networks. While optical strategies for making such measurements hold great promise, optical sensors generally lack the

Externí odkaz: https://doaj.org/article/996b05af41294092bb22962adfb58b1e

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Akademický článek

A first-passage approach to diffusion-influenced reversible binding and its insights into nanoscale signaling at the presynapse

Autor: Maria Reva, David A. DiGregorio, Denis S. Grebenkov

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)

Abstract Synaptic transmission between neurons is governed by a cascade of stochastic calcium ion reaction–diffusion events within nerve terminals leading to vesicular release of neurotransmitter. Since experimental measurements of such systems are

Externí odkaz: https://doaj.org/article/b040b918167b495f80b62a121bd38354

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Akademický článek

Underpinning heterogeneity in synaptic transmission by presynaptic ensembles of distinct morphological modules

Autor: Adam Fekete, Yukihiro Nakamura, Yi-Mei Yang, Stefan Herlitze, Melanie D. Mark, David A. DiGregorio, Lu-Yang Wang

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)

The mechanisms underlying synaptic heterogeneity of neurotransmission at mature calyx synapses remain unclear. Here, authors identify two morphological modules that have distinct topology of calcium channel clusters and spatial coupling distance to s

Externí odkaz: https://doaj.org/article/342e2fb457a34f4ab2812f5d3c07851d

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High frequency spike inference with particle Gibbs sampling

Autor: Giovanni Diana, B. Semihcan Sermet, David A. DiGregorio

Posted April 08, 2022 on bioRxiv.; International audience; Fluorescent calcium indicators are an indispensable tools for monitoring the spiking activity of large neuronal populations in animal models. However, despite the plethora of algorithms devel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::393d04ea9b262b563d0f58d833bd2381
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