Zobrazeno 1 - 10
of 36
pro vyhledávání: '"David A Degoey"'
Autor:
Peter Kovar, Paul L Richardson, Alla Korepanova, Gustavo A Afanador, Vladimir Stojkovic, Tao Li, Michael R Schrimpf, Teresa I Ng, David A Degoey, Sujatha M Gopalakrishnan, Jun Chen
Publikováno v:
SLAS Discovery, Vol 29, Iss 6, Pp 100179- (2024)
The SARS-CoV-2 main protease (Mpro) is essential for viral replication because it is responsible for the processing of most of the non-structural proteins encoded by the virus. Inhibition of Mpro prevents viral replication and therefore constitutes a
Externí odkaz:
https://doaj.org/article/0e0b9455143c4b4e883db21e8a29ec2c
Autor:
Teresa I. Ng, Ivan Correia, Jane Seagal, David A. DeGoey, Michael R. Schrimpf, David J. Hardee, Elizabeth L. Noey, Warren M. Kati
Publikováno v:
Viruses, Vol 14, Iss 5, p 961 (2022)
The coronavirus disease 2019 (COVID-19) pandemic is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a recently emerged human coronavirus. COVID-19 vaccines have proven to be successful in protecting the vaccinated from inf
Externí odkaz:
https://doaj.org/article/b0d076e9a22f4165b2f4dfc7ff36928e
Autor:
David A. Degoey, Alessandra Mattei, Rodger F. Henry, Gabriela Schneider-Rauber, Moiz Diwan, Ahmad Y. Sheikh, Kenneth M. Engstrom, Erin Jordan, Nathan S. Abraham, Richard S. Hong, Vivian Juarez, Rajni Miglani Bhardwaj, Charles W. Hutchins, Yi Gao
Publikováno v:
Journal of the American Chemical Society. 143:17479-17491
Direct-acting antiviral regimens have transformed therapeutic management of hepatitis C across all prevalent genotypes. Most of the chemical matter in these regimens comprises molecules well outside the traditional drug development chemical space and
Autor:
Kelly E. Desino, Balakrishna Hosmane, Stella Doktor, Edward Price, David A. Degoey, J. Cory Kalvass
Publikováno v:
Journal of Medicinal Chemistry. 64:9389-9403
Models intended to predict intestinal absorption are an essential part of the drug development process. Although many models exist for capturing intestinal absorption, many questions still exist around the applicability of these models to drug types
Autor:
David A. Degoey, Philip B. Cox
Publikováno v:
Burger's Medicinal Chemistry and Drug Discovery
Autor:
Meena V, Patel, Hillary M, Peltier, Mark A, Matulenko, John R, Koenig, Marc J, C Scanio, Rebecca J, Gum, Odile F, El-Kouhen, Meagan M, Fricano, Greta L, Lundgaard, Torben, Neelands, Xu-Feng, Zhang, Cenchen, Zhan, Madhavi, Pai, Nayereh, Ghoreishi-Haack, Thomas, Hudzik, Gary, Gintant, Ruth, Martin, Steve, McGaraughty, Jun, Xu, Daniel, Bow, John C, Kalvass, Philip R, Kym, David A, DeGoey, Michael E, Kort
Publikováno v:
Bioorganicmedicinal chemistry. 63
The voltage-gated sodium channel Na
Autor:
Meena V. Patel, Hillary M. Peltier, Mark A. Matulenko, John R. Koenig, Marc J. C. Scanio, Rebecca J. Gum, Odile F. El-Kouhen, Meagan M. Fricano, Greta L. Lundgaard, Torben Neelands, Xu-Feng Zhang, Cenchen Zhan, Madhavi Pai, Nayereh Ghoreishi-Haack, Thomas Hudzik, Gary Gintant, Ruth Martin, Steve McGaraughty, Jun Xu, Daniel Bow, John C. Kalvass, Philip R. Kym, David A. DeGoey, Michael E. Kort
Publikováno v:
Bioorganic & Medicinal Chemistry. 63:116743
Autor:
Jan E. Waters, Russell C. Klix, Jianguo Ji, John T. Randolph, Eric A. Voight, Greszler Stephen N, David A. Degoey, Bhadra H. Shelat, John Hartung
Publikováno v:
Chemical Science
A novel and practical desymmetrization tactic is described to access a new class of pibrentasvir prodrugs. The homotopic benzimidazoles of pibrentasvir (PIB) are differentiated via a one-pot di-Boc/mono-de-Boc selective N-Boc protection and formaldeh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a0d187ca8e4c54e2d10be7865a28bdb
https://doi.org/10.26434/chemrxiv.14456259.v1
https://doi.org/10.26434/chemrxiv.14456259.v1
Autor:
Eric A. Voight, John T. Randolph, Daniel A.J. Bow, James N Newton, Brice E Uno, Greszler Stephen N, David A. Degoey, DeAnne Stolarik, Kenneth M Gleason, Cecilia Van Handel
Publikováno v:
Journal of medicinal chemistry. 63(19)
A research program to discover solubilizing prodrugs of the HCV NS5A inhibitor pibrentasvir (PIB) identified phosphomethyl analog 2 and trimethyl-lock (TML) prodrug 9. The prodrug moiety is attached to a benzimidazole nitrogen atom via an oxymethyl l
Publikováno v:
Journal of Medicinal Chemistry. 61:2636-2651
Recently, there has been an increasing focus on the pursuit of targets considered to be less druggable that offer potential for development of promising new therapeutic agents for the treatment of diseases with large unmet medical need, particularly