Zobrazeno 1 - 10
of 373
pro vyhledávání: '"David A Christian"'
Autor:
Lindsey A Shallberg, Anthony T Phan, David A Christian, Joseph A Perry, Breanne E Haskins, Daniel P Beiting, Tajie H Harris, Anita A Koshy, Christopher A Hunter
Publikováno v:
PLoS Pathogens, Vol 18, Iss 6, p e1010296 (2022)
Initial TCR engagement (priming) of naive CD8+ T cells results in T cell expansion, and these early events influence the generation of diverse effector and memory populations. During infection, activated T cells can re-encounter cognate antigen, but
Externí odkaz:
https://doaj.org/article/e36f4bc3486d41dcb1fa8011ac3cf398
Autor:
Joseph T Clark, David A Christian, Jodi A Gullicksrud, Joseph A Perry, Jeongho Park, Maxime Jacquet, James C Tarrant, Enrico Radaelli, Jonathan Silver, Christopher A Hunter
Publikováno v:
eLife, Vol 10 (2021)
IL-33 is an alarmin required for resistance to the parasite Toxoplasma gondii, but its role in innate resistance to this organism is unclear. Infection with T. gondii promotes increased stromal cell expression of IL-33, and levels of parasite replica
Externí odkaz:
https://doaj.org/article/52e090cac47b4fec91345db4426581e2
Autor:
Gaia Muallem, Sagie Wagage, Yan Sun, Jonathan H DeLong, Alex Valenzuela, David A Christian, Gretchen Harms Pritchard, Qun Fang, Elizabeth L Buza, Deepika Jain, M Merle Elloso, Carolina B López, Christopher A Hunter
Publikováno v:
PLoS Pathogens, Vol 13, Iss 1, p e1006173 (2017)
Respiratory paramyxoviruses are important causes of morbidity and mortality, particularly of infants and the elderly. In humans, a T helper (Th)2-biased immune response to these infections is associated with increased disease severity; however, littl
Externí odkaz:
https://doaj.org/article/fede9b5bf3fe4e05802f0a6a11661c92
Publikováno v:
PLoS Computational Biology, Vol 11, Iss 2, p e1004058 (2015)
The three-dimensional positions of immune cells can be tracked in live tissues precisely as a function of time using two-photon microscopy. However, standard methods of analysis used in the field and experimental artifacts can bias interpretations an
Externí odkaz:
https://doaj.org/article/ae237b2c88ea4a73a163d42c1fd59e79
Autor:
Christopher D Dupont, David A Christian, Elizabeth M Selleck, Marion Pepper, Michael Leney-Greene, Gretchen Harms Pritchard, Anita A Koshy, Sagie Wagage, Morgan A Reuter, L David Sibley, Michael R Betts, Christopher A Hunter
Publikováno v:
PLoS Pathogens, Vol 10, Iss 4, p e1004047 (2014)
During infection with the intracellular parasite Toxoplasma gondii, the presentation of parasite-derived antigens to CD4+ and CD8+ T cells is essential for long-term resistance to this pathogen. Fundamental questions remain regarding the roles of pha
Externí odkaz:
https://doaj.org/article/2977843c3cf144dca58b9f44dc6e611a
Autor:
Daniel P Beiting, Lucia Peixoto, Natalia S Akopyants, Stephen M Beverley, E John Wherry, David A Christian, Christopher A Hunter, Igor E Brodsky, David S Roos
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88398 (2014)
The closely related protozoan parasites Toxoplasma gondii and Neospora caninum display similar life cycles, subcellular ultrastructure, invasion mechanisms, metabolic pathways, and genome organization, but differ in their host range and disease patho
Externí odkaz:
https://doaj.org/article/a5230609c1094dafa055494f4eedb004
Autor:
Anita A Koshy, Hans K Dietrich, David A Christian, Jason H Melehani, Anjali J Shastri, Christopher A Hunter, John C Boothroyd
Publikováno v:
PLoS Pathogens, Vol 8, Iss 7, p e1002825 (2012)
Like many intracellular microbes, the protozoan parasite Toxoplasma gondii injects effector proteins into cells it invades. One group of these effector proteins is injected from specialized organelles called the rhoptries, which have previously been
Externí odkaz:
https://doaj.org/article/2b76ff3628c14ad0a271899994cfc61c
Autor:
Beena John, Brendon Ricart, Elia D Tait Wojno, Tajie H Harris, Louise M Randall, David A Christian, Beth Gregg, Daniel Manzoni De Almeida, Wolfgang Weninger, Daniel A Hammer, Christopher A Hunter
Publikováno v:
PLoS Pathogens, Vol 7, Iss 9, p e1002246 (2011)
Under normal conditions the immune system has limited access to the brain; however, during toxoplasmic encephalitis (TE), large numbers of T cells and APCs accumulate within this site. A combination of real time imaging, transgenic reporter mice, and
Externí odkaz:
https://doaj.org/article/a7d1237e11404cccacd3c608f841b131
Autor:
Eva-Maria Wolfschmitt, Josef Albert Vogt, Melanie Hogg, Ulrich Wachter, Nicole Stadler, Thomas Kapapa, Thomas Datzmann, David Alexander Christian Messerer, Andrea Hoffmann, Michael Gröger, Franziska Münz, René Mathieu, Simon Mayer, Tamara Merz, Pierre Asfar, Enrico Calzia, Peter Radermacher, Fabian Zink
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
IntroductionSupplementation with increased inspired oxygen fractions has been suggested to alleviate the harmful effects of tissue hypoxia during hemorrhagic shock (HS) and traumatic brain injury. However, the utility of therapeutic hyperoxia in crit
Externí odkaz:
https://doaj.org/article/991bb70120ea4070bfbfec8007e78d77
Autor:
Marco Mannes, Rebecca Halbgebauer, Lisa Wohlgemuth, David Alexander Christian Messerer, Susa Savukoski, Anke Schultze, Bettina Berger, Christiane Leonie Knapp, Christoph Q. Schmidt, Daniel Fürst, Morten Hillmer, Reiner Siebert, Oskar Eriksson, Barbro Persson, Bo Nilsson, Kristina Nilsson Ekdahl, Markus Huber-Lang
Publikováno v:
Journal of Innate Immunity, Vol 15, Iss 1, Pp 412-427 (2023)
The complement system plays a crucial role in host defense, homeostasis, and tissue regeneration and bridges the innate and the adaptive immune systems. Although the genetic variants in complement C2 (c.839_849+17del; p.(Met280Asnfs*5)) and C8B (c.16
Externí odkaz:
https://doaj.org/article/62eadcbb7b1441f18d52e79ef47787c9