Zobrazeno 1 - 10
of 83
pro vyhledávání: '"David A Canton"'
Autor:
Jack Y. Lee, Bianca Nguyen, Anandaroop Mukhopadhyay, Mia Han, Jun Zhang, Ravindra Gujar, Jon Salazar, Reneta Hermiz, Lauren Svenson, Erica Browning, H. Kim Lyerly, David A. Canton, Daniel Fisher, Adil Daud, Alain Algazi, Joseph Skitzki, Christopher G. Twitty
Publikováno v:
Molecular Therapy: Oncolytics, Vol 25, Iss , Pp 174-188 (2022)
Clinical studies have demonstrated that local expression of the cytokine IL-12 drives interferon-gamma expression and recruits T cells to the tumor microenvironment, ultimately yielding durable systemic T cell responses. Interrogation of longitudinal
Externí odkaz:
https://doaj.org/article/e9b02e1da6b143caba62a394755fbbb0
Autor:
Nephi Stella, Linda Wordeman, Denny Liggitt, Rodney J.Y. Ho, John D. Scott, Juan Jesus Vicente, Barry Rickman, Eric A. Horne, Jonathan Coy, David A. Canton, Jennifer Freeling, Michael Wagenbach, Katie Swinney, Cong Xu, Susan Fung, Alipi V. Naydenov, Brian R. Haas, Allison E. Cherry
Figure S1: Representative histological features of orthotropic DBT tumor 3 weeks after implantation Figure S2: Semi-quantitative analysis of microglial invasion of DBT tumors Figure S3: ST-11 reduces proliferation and triggers apoptosis in DBT cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f3997f3f2ee600e57080d05a17f49ca
https://doi.org/10.1158/1535-7163.22504173.v1
https://doi.org/10.1158/1535-7163.22504173.v1
Autor:
Nephi Stella, Linda Wordeman, Denny Liggitt, Rodney J.Y. Ho, John D. Scott, Juan Jesus Vicente, Barry Rickman, Eric A. Horne, Jonathan Coy, David A. Canton, Jennifer Freeling, Michael Wagenbach, Katie Swinney, Cong Xu, Susan Fung, Alipi V. Naydenov, Brian R. Haas, Allison E. Cherry
T98G cell transfected with GFP-EB3 (green) to label growing MT tips and RFP-CenpB (red) to label centromeres. Speed = 10Ã-.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31002cf893c043e9dab6cebdc897e248
https://doi.org/10.1158/1535-7163.22504179
https://doi.org/10.1158/1535-7163.22504179
Autor:
Christopher G. Twitty, David A. Canton, Adil I. Daud, Alain P. Algazi, William L. Redmond, Annah S. Rolig, Lauren Svenson, Reneta Hermiz, Jon Salazar, Ravindra Gujar, Anandaroop Mukhopadhyay, Jun Zhang, Erica Browning, Jack Y. Lee, Bianca Nguyen, Mia Han
Supplementary Data from Intratumoral Electroporation of Plasmid Encoded IL12 and Membrane-Anchored Anti-CD3 Increases Systemic Tumor Immunity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a3eed745c165b1ea13499b90e81ce99
https://doi.org/10.1158/1541-7786.22527632
https://doi.org/10.1158/1541-7786.22527632
Autor:
Christopher G. Twitty, David A. Canton, Adil I. Daud, Alain P. Algazi, William L. Redmond, Annah S. Rolig, Lauren Svenson, Reneta Hermiz, Jon Salazar, Ravindra Gujar, Anandaroop Mukhopadhyay, Jun Zhang, Erica Browning, Jack Y. Lee, Bianca Nguyen, Mia Han
Supplementary Figure from Intratumoral Electroporation of Plasmid Encoded IL12 and Membrane-Anchored Anti-CD3 Increases Systemic Tumor Immunity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20466e5b01e1b903fcdd11ec077f3365
https://doi.org/10.1158/1541-7786.22527629
https://doi.org/10.1158/1541-7786.22527629
Autor:
Mia Han, Bianca Nguyen, Jack Y. Lee, Erica Browning, Jun Zhang, Anandaroop Mukhopadhyay, Ravindra Gujar, Jon Salazar, Reneta Hermiz, Lauren Svenson, Annah S. Rolig, William L. Redmond, Alain P. Algazi, Adil I. Daud, David A. Canton, Christopher G. Twitty
Publikováno v:
Molecular Cancer Research. 20:983-995
Intratumoral delivery of plasmid IL12 via electroporation (IT-tavo-EP) induces localized expression of IL12 leading to regression of treated and distant tumors with durable responses and minimal toxicity. A key driver in amplifying this local therapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcb1d8e7ce24644cfbc5c4231489a40c
https://doi.org/10.1158/1541-7786.mcr-21-0834
https://doi.org/10.1158/1541-7786.mcr-21-0834
Autor:
Melinda L. Telli, Irene Wapnir, Bianca Devitt, Katharine Cuff, Hatem Soliman, Shaveta Vinayak, David A. Canton, Christopher G. Twitty, Sunny Xie, Ying Lu, Donna Bannavong, Bridget O'Keeffe, Sandra Aung, Rohit Joshi
Publikováno v:
Cancer Research. 82:P2-14
BACKGROUND: Electroporated plasmid interleukin-12 (tavokinogene telseplasmid; TAVO-EP) delivered to accessible tumors by intratumoral injection induces sustained local expression of IL-12. IL-12 is a potent immunoregulatory cytokine that plays a key
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53bf2b045cd6ee834f70202b48df7dfd
https://doi.org/10.1158/1538-7445.sabcs21-p2-14-06
https://doi.org/10.1158/1538-7445.sabcs21-p2-14-06
Autor:
Erika J. Crosby, H. Kim Lyerly, Takuya Osada, Christopher G. Twitty, David A. Canton, Kellie Malloy Foerter, Jendy Sell, Kim Jaffe, Donna Bannavong, Lauren Svenson, Reneta Hermiz, Erica Browning, Robert H. Pierce, Mai Hope Le, Carmen Ballesteros-Merino, Shawn M. Jensen, Carlo B. Bifulco, Bernard A. Fox, Kaitlin Zablotsky, Chaitanya R. Acharya, Irene Wapnir, Hiroshi Nagata, Melinda L. Telli
Purpose:Triple-negative breast cancer (TNBC) is an aggressive disease with limited therapeutic options. Antibodies targeting programmed cell death protein 1 (PD-1)/PD-1 ligand 1 (PD-L1) have entered the therapeutic landscape in TNBC, but only a minor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e551cda28c1fd25f0ef23972aa309b8
https://doi.org/10.1158/1078-0432.c.6531311.v1
https://doi.org/10.1158/1078-0432.c.6531311.v1
Autor:
Erika J. Crosby, H. Kim Lyerly, Takuya Osada, Christopher G. Twitty, David A. Canton, Kellie Malloy Foerter, Jendy Sell, Kim Jaffe, Donna Bannavong, Lauren Svenson, Reneta Hermiz, Erica Browning, Robert H. Pierce, Mai Hope Le, Carmen Ballesteros-Merino, Shawn M. Jensen, Carlo B. Bifulco, Bernard A. Fox, Kaitlin Zablotsky, Chaitanya R. Acharya, Irene Wapnir, Hiroshi Nagata, Melinda L. Telli
Figure S5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44a596ca06ec554d854aa13d403d5a24
https://doi.org/10.1158/1078-0432.22484048
https://doi.org/10.1158/1078-0432.22484048
Autor:
Adil I. Daud, Michael D. Rosenblum, Bernard A. Fox, Robert H.I. Andtbacka, Sharron Gargosky, Shailender Bhatia, Carmen Ballesteros-Merino, Carlos Bifulco, Lauren P. Levine, Christopher Garris, Sean P. Arlauckas, Mikael J. Pittet, Lawrence Fong, Murray Francisco, Arielle Oglesby, Donna Bannavong, David A. Canton, Reneta Hermiz, Erica Browning, Robert Pierce, Mai Le, Katy K. Tsai, Christopher G. Twitty, Alain P. Algazi
Treatment related changes in cell type scores
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c2dab53da92d4304d25e1a122adb363
https://doi.org/10.1158/1078-0432.22477617
https://doi.org/10.1158/1078-0432.22477617