Genome-wide determinants of mortality and motor progression in Parkinson’s disease

Autor: Manuela M. X. Tan, Michael A. Lawton, Miriam I. Pollard, Emmeline Brown, Raquel Real, Alejandro Martinez Carrasco, Samir Bekadar, Edwin Jabbari, Regina H. Reynolds, Hirotaka Iwaki, Cornelis Blauwendraat, Sofia Kanavou, Leon Hubbard, Naveed Malek, Katherine A. Grosset, Nin Bajaj, Roger A. Barker, David J. Burn, Catherine Bresner, Thomas Foltynie, Nicholas W. Wood, Caroline H. Williams-Gray, Ole A. Andreassen, Mathias Toft, Alexis Elbaz, Fanny Artaud, Alexis Brice, Jean-Christophe Corvol, Jan Aasly, Matthew J. Farrer, Michael A. Nalls, Andrew B. Singleton, Nigel M. Williams, Yoav Ben-Shlomo, John Hardy, Michele T. M. Hu, Donald G. Grosset, Maryam Shoai, Lasse Pihlstrøm, Huw R. Morris

Publikováno v: npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-15 (2024)

Abstract There are 90 independent genome-wide significant genetic risk variants for Parkinson’s disease (PD) but currently only five nominated loci for PD progression. The biology of PD progression is likely to be of central importance in defining

Externí odkaz: https://doaj.org/article/b1dcf9f75c9e4bc4bc4699609e993749

Chiral structures of electric polarization vectors quantified by X-ray resonant scattering

Autor: Kook Tae Kim, Margaret R. McCarter, Vladimir A. Stoica, Sujit Das, Christoph Klewe, Elizabeth P. Donoway, David M. Burn, Padraic Shafer, Fanny Rodolakis, Mauro A. P. Gonçalves, Fernando Gómez-Ortiz, Jorge Íñiguez, Pablo García-Fernández, Javier Junquera, Sandhya Susarla, Stephen W. Lovesey, Gerrit van der Laan, Se Young Park, Lane W. Martin, John W. Freeland, Ramamoorthy Ramesh, Dong Ryeol Lee

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)

The polar chiral texture of the vortex or skyrmion structure in ferroelectric oxide PbTiO3/SrTiO3 superlattice attracts attention. Here, the authors report a theoretical framework to probe emergent chirality of electrical polarization textures.

Externí odkaz: https://doaj.org/article/620f213fed1b4658ad79d0bed21ab529

Documentation and diagnosis of delirium in Parkinson's disease

Autor: Rachel J. Cullinan, Sarah J. Richardson, Alison J. Yarnall, David J. Burn, Louise M. Allan, Rachael A. Lawson

Publikováno v: Acta Psychiatrica Scandinavica. 147:527-535

To assess the accuracy of documentation of the symptoms and diagnosis of delirium in medical notes of inpatients with Parkinson's disease (PD).The DETERMINE-PD pilot study assessed PD inpatients over 4-months. Delirium prevalence was classified prosp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b3aa35abbc5859061d49f52bfac2f58
https://doi.org/10.1111/acps.13470

Structural Chirality of Polar Skyrmions Probed by Resonant Elastic X-Ray Scattering

Autor: Margaret R. McCarter, Kook Tae Kim, Vladimir A. Stoica, Sujit Das, Christoph Klewe, Elizabeth P. Donoway, David M. Burn, Padraic Shafer, Fanny Rodolakis, Mauro A. P. Gonçalves, Fernando Gómez-Ortiz, Jorge Íñiguez, Pablo García-Fernández, Javier Junquera, Stephen W. Lovesey, Gerrit van der Laan, Se Young Park, John W. Freeland, Lane W. Martin, Dong Ryeol Lee, Ramamoorthy Ramesh

Publikováno v: Physical Review Letters, 2022, 129(24), 247601

An escalating challenge in condensed-matter research is the characterization of emergent order-parameter nanostructures such as ferroelectric and ferromagnetic skyrmions. Their small length scales coupled with complex, three-dimensional polarization

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::598b09dd7a2439f7de2bc6dcb43a5259
https://doi.org/10.1103/physrevlett.129.247601

Genetics of validated Parkinson’s Disease subtypes in the Oxford Discovery and Tracking Parkinson’s cohorts

Autor: Michael Lawton, Manuela MX Tan, Yoav Ben-Shlomo, Fahd Baig, Thomas Barber, Johannes C Klein, Samuel G Evetts, Stephanie Millin, Naveed Malek, Katherine Grosset, Roger A Barker, Nigel Williams, David J Burn, Thomas Foltynie, Huw R Morris, Nicholas Wood, Donald G Grosset, Michele Tao-Ming Hu

Publikováno v: Lawton, M A, Tan, M M X, Ben-Shlomo, Y, Baig, F, Barber, T, Klein, J C, Evetts, S G, Millin, S, Malek, N, Grosset, K, Barker, R A, Williams, N, Burn, D J, Foltynie, T, Morris, H R, Wood, N, Grosset, D G & Hu, M T M 2022, ' Genetics of validated Parkinson’s Disease subtypes in the Oxford Discovery and Tracking Parkinson’s cohorts ', Journal of Neurology, Neurosurgery, and Psychiatry, vol. 93, no. 9, pp. 952–959 . https://doi.org/10.1136/jnnp-2021-327376

ObjectivesTo explore the genetics of four Parkinson’s disease (PD) subtypes that have been previously described in two large cohorts of patients with recently diagnosed PD. These subtypes came from a data-driven cluster analysis of phenotypic varia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84b6dddde338410fc5e014208a6d3f0f
https://hdl.handle.net/1983/e2b3f541-74b1-4b74-a59f-85859656f465