Zobrazeno 1 - 10
of 97
pro vyhledávání: '"David A Bechtold"'
Autor:
Chris Cook, Nicolas Nunn, Amy A Worth, David A Bechtold, Todd Suter, Susan Gackeheimer, Lisa Foltz, Paul J Emmerson, Michael A Statnick, Simon M Luckman
Publikováno v:
PLoS ONE, Vol 17, Iss 10, p e0275604 (2022)
Here we show that central administration of pyroglutamylated arginine-phenylamine-amide peptide (QRFP/26RFa) increases both food intake and locomotor activity, without any significant effect on energy expenditure, thermogenesis or reward. Germline kn
Externí odkaz:
https://doaj.org/article/0af82c5774d44bb2821e9966ad5eff56
Autor:
Ann Louise Hunter, Charlotte E Pelekanou, Nichola J Barron, Rebecca C Northeast, Magdalena Grudzien, Antony D Adamson, Polly Downton, Thomas Cornfield, Peter S Cunningham, Jean-Noel Billaud, Leanne Hodson, Andrew SI Loudon, Richard D Unwin, Mudassar Iqbal, David W Ray, David A Bechtold
Publikováno v:
eLife, Vol 10 (2021)
The circadian clock component NR1D1 (REVERBα) is considered a dominant regulator of lipid metabolism, with global Nr1d1 deletion driving dysregulation of white adipose tissue (WAT) lipogenesis and obesity. However, a similar phenotype is not observe
Externí odkaz:
https://doaj.org/article/ea65ba8216cf4fc8be509f4be399aaf8
Autor:
Matthew Baxter, Maria Voronkov, Toryn Poolman, Gina Galli, Christian Pinali, Laurence Goosey, Abigail Knight, Karolina Krakowiak, Robert Maidstone, Mudassar Iqbal, Min Zi, Sukhpal Prehar, Elizabeth J Cartwright, Julie Gibbs, Laura C Matthews, Antony D Adamson, Neil E Humphreys, Pedro Rebelo-Guiomar, Michal Minczuk, David A Bechtold, Andrew Loudon, David Ray
Publikováno v:
eLife, Vol 9 (2020)
Efficient mitochondrial function is required in tissues with high energy demand such as the heart, and mitochondrial dysfunction is associated with cardiovascular disease. Expression of mitochondrial proteins is tightly regulated in response to inter
Externí odkaz:
https://doaj.org/article/c80495bec8114315bceead7ae22ca77e
Autor:
Hugh D Piggins, David A Bechtold
Publikováno v:
eLife, Vol 4 (2015)
A hormone released from the gut after a meal can reset clock gene activity in the liver.
Externí odkaz:
https://doaj.org/article/8ca54f12732a4f2c87dfab1f59cca868
Autor:
Lauren Walmsley, Lydia Hanna, Josh Mouland, Franck Martial, Alexander West, Andrew R Smedley, David A Bechtold, Ann R Webb, Robert J Lucas, Timothy M Brown
Publikováno v:
PLoS Biology, Vol 13, Iss 4, p e1002127 (2015)
Twilight is characterised by changes in both quantity ("irradiance") and quality ("colour") of light. Animals use the variation in irradiance to adjust their internal circadian clocks, aligning their behaviour and physiology with the solar cycle. How
Externí odkaz:
https://doaj.org/article/3b112f7e6f8443528b0d0798da3b46ab
Publikováno v:
Open Biology, Vol 14, Iss 7 (2024)
Rheumatoid arthritis is a chronic inflammatory disease that shows characteristic diurnal variation in symptom severity, where joint resident fibroblast-like synoviocytes (FLS) act as important mediators of arthritis pathology. We investigate the role
Externí odkaz:
https://doaj.org/article/66b3aadbc6b24d708c7eb5a389aa1c52
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23725 (2011)
GPR50 is an orphan G-protein coupled receptor most closely related to the melatonin receptors. The physiological function of GPR50 remains unclear, although our previous studies implicate the receptor in energy homeostasis. Here, we reveal a role for
Externí odkaz:
https://doaj.org/article/fcde38d56643411aa92f9ab43a813eef
Autor:
Fleur Talbot, Claire H. Feetham, Jacek Mokrosiński, Katherine Lawler, Julia M. Keogh, Elana Henning, Edson Mendes de Oliveira, Vikram Ayinampudi, Sadia Saeed, Amélie Bonnefond, Mohammed Arslan, Giles S. H. Yeo, Philippe Froguel, David A. Bechtold, Antony Adamson, Neil Humphreys, Inês Barroso, Simon M. Luckman, I. Sadaf Farooqi
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
The brain-expressed receptor GPR10 is involved in energy homeostasis in mice. Here the authors identify rare loss of function variants in GPR10 in people with severe obesity and showed that one of these variants causes obesity when modelled in mice,
Externí odkaz:
https://doaj.org/article/ae488579c70a4e4895c6b257ff54f30c
Autor:
Andrew D. Beale, Priya Crosby, Utham Kashyap Valekunja, Rachel S Edgar, Johanna Chesham, Elizabeth Maywood, Fatima Hanna Labeed, Akhilesh B Reddy, Kenneth P Wright, Kathryn S. Lilley, Michael Harvey Hastings, John Stuart O'Neill, David A Bechtold, Edward A Hayter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49191be61e5bbd716964e321a87677be
https://doi.org/10.15252/rc.2023492254
https://doi.org/10.15252/rc.2023492254
Autor:
Devin Amanda Simpkins, Polly Downton, Kathryn J. Gray, Suzanna H. Dickson, Robert J. Maidstone, Joanne E. Konkel, Matthew R. Hepworth, David W. Ray, David A. Bechtold, Julie Elizabeth Gibbs
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental BiologyREFERENCES. 37(1)
The gut microbiota is important for host health and immune system function. Moreover autoimmune diseases, such as rheumatoid arthritis, are associated with significant gut microbiota dysbiosis, although the causes and consequences of this are not ful
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::446e3b992465de000d4596166beda59c
https://pubmed.ncbi.nlm.nih.gov/36520064
https://pubmed.ncbi.nlm.nih.gov/36520064