Zobrazeno 1 - 10
of 178
pro vyhledávání: '"David A Bechtold"'
Publikováno v:
Open Biology, Vol 14, Iss 7 (2024)
Rheumatoid arthritis is a chronic inflammatory disease that shows characteristic diurnal variation in symptom severity, where joint resident fibroblast-like synoviocytes (FLS) act as important mediators of arthritis pathology. We investigate the role
Externí odkaz:
https://doaj.org/article/66b3aadbc6b24d708c7eb5a389aa1c52
Autor:
Fleur Talbot, Claire H. Feetham, Jacek Mokrosiński, Katherine Lawler, Julia M. Keogh, Elana Henning, Edson Mendes de Oliveira, Vikram Ayinampudi, Sadia Saeed, Amélie Bonnefond, Mohammed Arslan, Giles S. H. Yeo, Philippe Froguel, David A. Bechtold, Antony Adamson, Neil Humphreys, Inês Barroso, Simon M. Luckman, I. Sadaf Farooqi
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
The brain-expressed receptor GPR10 is involved in energy homeostasis in mice. Here the authors identify rare loss of function variants in GPR10 in people with severe obesity and showed that one of these variants causes obesity when modelled in mice,
Externí odkaz:
https://doaj.org/article/ae488579c70a4e4895c6b257ff54f30c
Autor:
Alessandra Stangherlin, Joseph L. Watson, David C. S. Wong, Silvia Barbiero, Aiwei Zeng, Estere Seinkmane, Sew Peak Chew, Andrew D. Beale, Edward A. Hayter, Alina Guna, Alison J. Inglis, Marrit Putker, Eline Bartolami, Stefan Matile, Nicolas Lequeux, Thomas Pons, Jason Day, Gerben van Ooijen, Rebecca M. Voorhees, David A. Bechtold, Emmanuel Derivery, Rachel S. Edgar, Peter Newham, John S. O’Neill
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Osmotic compensation by electroneutral ion transport buffers TORC1-mediated changes in the cytosolic proteome, and maintains intracellular homeostasis and cell volume over the circadian cycle. Here, the authors find such ion content changes drive dai
Externí odkaz:
https://doaj.org/article/d608bbcc713a4841b6211ae27b0bfe88
Autor:
Edward A. Hayter, Sophie M. T. Wehrens, Hans P. A. Van Dongen, Alessandra Stangherlin, Shobhan Gaddameedhi, Elena Crooks, Nichola J. Barron, Luigi A. Venetucci, John S. O’ Neill, Timothy M. Brown, Debra J. Skene, Andrew W. Trafford, David A. Bechtold
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Cardiac function fluctuates greatly across the day and night, but this is not simply a consequence of our changing behaviour. The authors highlight the role of the body’s circadian clock in regulating the heart electrical activity, including a time
Externí odkaz:
https://doaj.org/article/530c60e952014c1cb2858a92a8c76775
Publikováno v:
BMC Biology, Vol 18, Iss 1, Pp 1-16 (2020)
Abstract Background Daily variations in mammalian physiology are under control of a central clock in the suprachiasmatic nucleus (SCN). SCN timing signals are essential for coordinating cellular clocks and associated circadian variations in cell and
Externí odkaz:
https://doaj.org/article/e30f64996848408f9eaf0c32cb2d8b46
Autor:
Sarika Paul, Lydia Hanna, Court Harding, Edward A. Hayter, Lauren Walmsley, David A. Bechtold, Timothy M. Brown
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
VIP-expressing neurons play a central role in circadian timekeeping within the mammalian central clock. Here the authors use opto- and chemogenetic approaches to show that VIP neuronal activity regulates rhythmic activity in downstream hypothalamic t
Externí odkaz:
https://doaj.org/article/16d76bcc2be2406ea4926ed3ab5d9eeb
Autor:
Chris Cook, Nicolas Nunn, Amy A Worth, David A Bechtold, Todd Suter, Susan Gackeheimer, Lisa Foltz, Paul J Emmerson, Michael A Statnick, Simon M Luckman
Publikováno v:
PLoS ONE, Vol 17, Iss 10, p e0275604 (2022)
Here we show that central administration of pyroglutamylated arginine-phenylamine-amide peptide (QRFP/26RFa) increases both food intake and locomotor activity, without any significant effect on energy expenditure, thermogenesis or reward. Germline kn
Externí odkaz:
https://doaj.org/article/0af82c5774d44bb2821e9966ad5eff56
Autor:
Ann Louise Hunter, Charlotte E Pelekanou, Nichola J Barron, Rebecca C Northeast, Magdalena Grudzien, Antony D Adamson, Polly Downton, Thomas Cornfield, Peter S Cunningham, Jean-Noel Billaud, Leanne Hodson, Andrew SI Loudon, Richard D Unwin, Mudassar Iqbal, David W Ray, David A Bechtold
Publikováno v:
eLife, Vol 10 (2021)
The circadian clock component NR1D1 (REVERBα) is considered a dominant regulator of lipid metabolism, with global Nr1d1 deletion driving dysregulation of white adipose tissue (WAT) lipogenesis and obesity. However, a similar phenotype is not observe
Externí odkaz:
https://doaj.org/article/ea65ba8216cf4fc8be509f4be399aaf8
Autor:
Heming Wang, Jacqueline M. Lane, Samuel E. Jones, Hassan S. Dashti, Hanna M. Ollila, Andrew R. Wood, Vincent T. van Hees, Ben Brumpton, Bendik S. Winsvold, Katri Kantojärvi, Teemu Palviainen, Brian E. Cade, Tamar Sofer, Yanwei Song, Krunal Patel, Simon G. Anderson, David A. Bechtold, Jack Bowden, Richard Emsley, Simon D. Kyle, Max A. Little, Andrew S. Loudon, Frank A. J. L. Scheer, Shaun M. Purcell, Rebecca C. Richmond, Kai Spiegelhalder, Jessica Tyrrell, Xiaofeng Zhu, Christer Hublin, Jaakko A. Kaprio, Kati Kristiansson, Sonja Sulkava, Tiina Paunio, Kristian Hveem, Jonas B. Nielsen, Cristen J. Willer, John-Anker Zwart, Linn B. Strand, Timothy M. Frayling, David Ray, Deborah A. Lawlor, Martin K. Rutter, Michael N. Weedon, Susan Redline, Richa Saxena
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
A main symptom of chronic insufficient sleep is excessive daytime sleepiness. Here, Wang et al. report 42 genome-wide significant loci for self-reported daytime sleepiness in 452,071 individuals from the UK Biobank that cluster into two biological su
Externí odkaz:
https://doaj.org/article/ab82094d6f1747f6b19a7f7da87c85b4
Autor:
Hassan S. Dashti, Samuel E. Jones, Andrew R. Wood, Jacqueline M. Lane, Vincent T. van Hees, Heming Wang, Jessica A. Rhodes, Yanwei Song, Krunal Patel, Simon G. Anderson, Robin N. Beaumont, David A. Bechtold, Jack Bowden, Brian E. Cade, Marta Garaulet, Simon D. Kyle, Max A. Little, Andrew S. Loudon, Annemarie I. Luik, Frank A. J. L. Scheer, Kai Spiegelhalder, Jessica Tyrrell, Daniel J. Gottlieb, Henning Tiemeier, David W. Ray, Shaun M. Purcell, Timothy M. Frayling, Susan Redline, Deborah A. Lawlor, Martin K. Rutter, Michael N. Weedon, Richa Saxena
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Sleep is essential for homeostasis and insufficient or excessive sleep are associated with adverse outcomes. Here, the authors perform GWAS for self-reported habitual sleep duration in adults, supported by accelerometer-derived measures, and identify
Externí odkaz:
https://doaj.org/article/8b6de6977fc0471092cd5660f81e6ac1