Zobrazeno 1 - 10
of 43
pro vyhledávání: '"David A, Tumbarello"'
Autor:
Naomi J. Thorne, David A. Tumbarello
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Maintenance of mitochondrial health is essential for neuronal survival and relies upon dynamic changes in the mitochondrial network and effective mitochondrial quality control mechanisms including the mitochondrial-derived vesicle pathway and mitopha
Externí odkaz:
https://doaj.org/article/7b51804c72f445fba37fa593253911f9
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Externí odkaz:
https://doaj.org/article/731d3e4dd7cb47038a46e25b7b920cfa
Autor:
Emelia A. Assar, David A. Tumbarello
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Autophagy is an essential catabolic intracellular pathway that maintains homeostasis by degrading long-lived proteins, damaged organelles, and provides an energy source during nutrient starvation. It is now understood that autophagy has discrete func
Externí odkaz:
https://doaj.org/article/322e1e7f629b463dbc10658809027e34
Autor:
Thomas A Ryan, David A Tumbarello
Publikováno v:
Neural Regeneration Research, Vol 16, Iss 9, Pp 1779-1780 (2021)
Externí odkaz:
https://doaj.org/article/a1e346a0f5ef45dbbd24f4c55c3d4e7e
MYO6 Regulates Spatial Organization of Signaling Endosomes Driving AKT Activation and Actin Dynamics
Publikováno v:
Cell Reports, Vol 19, Iss 10, Pp 2088-2101 (2017)
APPL1- and RAB5-positive signaling endosomes play a crucial role in the activation of AKT in response to extracellular stimuli. Myosin VI (MYO6) and two of its cargo adaptor proteins, GIPC and TOM1/TOM1L2, localize to these peripheral endosomes and m
Externí odkaz:
https://doaj.org/article/f33ebf36f3844a7db12a9ad1e1d7cd85
Autor:
Savannah A. Lynn, Eloise Keeling, Jennifer M. Dewing, David A. Johnston, Anton Page, Angela J. Cree, David A. Tumbarello, Tracey A. Newman, Andrew J. Lotery, J. Arjuna Ratnayaka
Publikováno v:
F1000Research, Vol 7 (2018)
The retinal pigment epithelium (RPE) plays a key role in the pathogenesis of several blinding retinopathies. Alterations to RPE structure and function are reported in Age-related Macular Degeneration, Stargardt and Best disease as well as pattern dys
Externí odkaz:
https://doaj.org/article/806a7f95156b4dba8deadf7db67b425d
Autor:
Thomas A. Ryan, David A. Tumbarello
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Optineurin is a multifunctional adaptor protein intimately involved in various vesicular trafficking pathways. Through interactions with an array of proteins, such as myosin VI, huntingtin, Rab8, and Tank-binding kinase 1, as well as via its oligomer
Externí odkaz:
https://doaj.org/article/3b955b75b3aa41479836f3cd44a00b32
Autor:
Jane K. Cleal, David A. Tumbarello, Nicholas C. Harvey, Laura D.F. Cooke, Rohan M. Lewis, Jaswinder K. Sethi
Publikováno v:
Placenta. 113:67-73
Endocytosis is an essential mechanism for cellular uptake in many human tissues. A range of endocytic mechanisms occur including clathrin-dependent and -independent mechanisms. However, the role of endocytosis in the placenta and the spatial localisa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9a254c1da5e9d516b1c6ed53c34813c
https://doi.org/10.1016/j.placenta.2021.04.014
https://doi.org/10.1016/j.placenta.2021.04.014
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0162698 (2016)
TGFBI has been shown to sensitize ovarian cancer cells to the cytotoxic effects of paclitaxel via an integrin receptor-mediated mechanism that modulates microtubule stability. Herein, we determine that TGFBI localizes within organized fibrillar struc
Externí odkaz:
https://doaj.org/article/c9247f4849f143af8cc3bc0dc5629985
Autor:
David A Tumbarello, Paul T Manna, Mark Allen, Mark Bycroft, Susan D Arden, John Kendrick-Jones, Folma Buss
Publikováno v:
PLoS Pathogens, Vol 12, Iss 1, p e1005433 (2016)
[This corrects the article DOI: 10.1371/journal.ppat.1005174.].
Externí odkaz:
https://doaj.org/article/dfe6088a6ca2496580c3c16e31914ac9