Výsledky vyhledávání - "David A, Solomon"

Akademický článek

Conserved features of TERT promoter duplications reveal an activation mechanism that mimics hotspot mutations in cancer

Autor: Carter J. Barger, Abigail K. Suwala, Katarzyna M. Soczek, Albert S. Wang, Min Y. Kim, Chibo Hong, Jennifer A. Doudna, Susan M. Chang, Joanna J. Phillips, David A. Solomon, Joseph F. Costello

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)

TERT promoter mutations are the most common noncoding alterations in cancers, although some remain to be characterised. Here, the authors identify TERT promoter duplications across seven cancer types that are functionally equivalent to well-known hot

Externí odkaz: https://doaj.org/article/a11e544533df4a98816dfb5ed7b18481

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Akademický článek

Susceptibility pattern of methicillin resistance Staphylococcus aureus (MRSA) by flow cytometry analysis and characterization of novel lead drug molecule from Streptomyces species

Autor: Ganesan Govindarajan, Priya Mullick, Babu Arulmani Samuel Raj, Pachaiyappan Saravana Kumar, Mysoon M. Al-Ansari, Soundharrajan Ilavenil, Robinson David Jebakumar Solomon

Publikováno v: Journal of Infection and Public Health, Vol 14, Iss 12, Pp 1831-1841 (2021)

Background: Actinomycetes particularly, Streptomyces species are producing wide variety of natural products with potential bioactivities. The microbial-derived metabolites hold a strong position to combat emerging and re-emerging antimicrobial drug-r

Externí odkaz: https://doaj.org/article/08499cf5b2b2464cb529d8d8713d2875

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Akademický článek

Comprehensive analysis of diverse low-grade neuroepithelial tumors with FGFR1 alterations reveals a distinct molecular signature of rosette-forming glioneuronal tumor

Autor: Calixto-Hope G. Lucas, Rohit Gupta, Pamela Doo, Julieann C. Lee, Cathryn R. Cadwell, Biswarathan Ramani, Jeffrey W. Hofmann, Emily A. Sloan, Bette K. Kleinschmidt-DeMasters, Han S. Lee, Matthew D. Wood, Marjorie Grafe, Donald Born, Hannes Vogel, Shahriar Salamat, Diane Puccetti, David Scharnhorst, David Samuel, Tabitha Cooney, Elaine Cham, Lee-way Jin, Ziad Khatib, Ossama Maher, Gabriel Chamyan, Carole Brathwaite, Serguei Bannykh, Sabine Mueller, Cassie N. Kline, Anu Banerjee, Alyssa Reddy, Jennie W. Taylor, Jennifer L. Clarke, Nancy Ann Oberheim Bush, Nicholas Butowski, Nalin Gupta, Kurtis I. Auguste, Peter P. Sun, Jarod L. Roland, Corey Raffel, Manish K. Aghi, Philip Theodosopoulos, Edward Chang, Shawn Hervey-Jumper, Joanna J. Phillips, Melike Pekmezci, Andrew W. Bollen, Tarik Tihan, Susan Chang, Mitchel S. Berger, Arie Perry, David A. Solomon

Publikováno v: Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-17 (2020)

Abstract The FGFR1 gene encoding fibroblast growth factor receptor 1 has emerged as a frequently altered oncogene in the pathogenesis of multiple low-grade neuroepithelial tumor (LGNET) subtypes including pilocytic astrocytoma, dysembryoplastic neuro

Externí odkaz: https://doaj.org/article/3a46ceae1a2346d09a785ac62bd3c17d

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Akademický článek

DNA methylation profiling demonstrates superior diagnostic classification to RNA-sequencing in a case of metastatic meningioma

Autor: Harish N. Vasudevan, Maria R. H. Castro, Julieann C. Lee, Javier E. Villanueva-Meyer, Nancy Ann Oberheim Bush, Michael W. McDermott, David A. Solomon, Arie Perry, Stephen T. Magill, David R. Raleigh

Publikováno v: Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-6 (2020)

Abstract Meningiomas are the most common primary intracranial tumors, but meningioma metastases are rare. Accordingly, the clinical workup, diagnostic testing, and molecular classification of metastatic meningioma is incompletely understood. Here, we

Externí odkaz: https://doaj.org/article/a0e29aeed3c24f79b1c81e45222621a9

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Akademický článek

Catastrophic stroke burden in a patient with uncontrolled psoriasis and psoriatic arthritis: a case report

Autor: Joline M. Fan, David A. Solomon, Giselle Y. López, Jeffrey W. Hofmann, Rene A. Colorado, Anthony S. Kim, Karl Meisel, Cathra Halabi

Publikováno v: BMC Neurology, Vol 20, Iss 1, Pp 1-7 (2020)

Abstract Background Psoriasis is the most common chronic inflammatory condition involving the T helper cell system. Population studies have demonstrated that patients with psoriasis and/or psoriatic arthritis have an increased risk of developing vasc

Externí odkaz: https://doaj.org/article/d84ecd8a24064a8290fe17f9d41c18cf

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Akademický článek

An unusual recurrent high-grade glioneuronal tumor with MAP2K1 mutation and CDKN2A/B homozygous deletion

Autor: Barry Cheaney, Stephen Bowden, Katie Krause, Emily A. Sloan, Arie Perry, David A. Solomon, Seunggu Jude Han, Matthew D. Wood

Publikováno v: Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-4 (2019)

Externí odkaz: https://doaj.org/article/686c2238955a40ccb15cf8c7981c2ee3

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Akademický článek

A requirement for STAG2 in replication fork progression creates a targetable synthetic lethality in cohesin-mutant cancers

Autor: Gourish Mondal, Meredith Stevers, Benjamin Goode, Alan Ashworth, David A. Solomon

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)

Cohesin complex mediates cohesion of sister chromatids and DNA loop formation. Here the authors show another role of cohesin in replication fork progression, suggesting a potential therapeutic strategy for cohesin-mutant cancers.

Externí odkaz: https://doaj.org/article/bd142773bd634488bdd09820a09ed0b2

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