An in vitro tumorigenesis model based on live-cell-generated oxygen and nutrient gradients

Autor: Anne C. Gilmore, Sarah J. Flaherty, Veena Somasundaram, David A. Scheiblin, Stephen J. Lockett, David A. Wink, William F. Heinz

Publikováno v: Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)

Gilmore et al. describe an in vitro tumorigenesis model that produces cell-generated gradients of oxygen and nutrients. Its 2D configuration simplifies live cell, immunofluorescent, and microscopic interrogation of cancer cell behaviour in differenti

Externí odkaz: https://doaj.org/article/e13ab04655bc4d119008eaaf1d13d34b

HIV-1 Envelope Glycoprotein Trafficking and Viral Transmission

Autor: Melissa Victoria Fernandez, Lwar N Naing, David A Scheiblin, Sherimay D Ablan, Jennifer A Simmons, Eric O Freed

Publikováno v: Proceedings, Vol 50, Iss 1, p 17 (2020)

HIV-1 encodes an envelope glycoprotein complex (Env) containing a long cytoplasmic tail (CT) harboring trafficking motifs implicated in Env incorporation into virions. Although the requirement for the Env CT in viral transmission is known, the precis

Externí odkaz: https://doaj.org/article/7ee04b30fab2457da5c4e1c447f024b2

NOS2 and COX2 Blockade Limits TNBC Disease Progression and Alters CD8+T Cell Spatial Orientation and Density

Autor: Veena Somasundaram, Lisa A Ridnour, Robert YS Cheng, Abigail J Walke, Noemi Kedei, Dibyangana D Bhattacharyya, Adelaide L Wink, Elijah F Edmondson, Donna Butcher, Andrew Warner, Tiffany H Dorsey, David A Scheiblin, William Heinz, Richard J. Bryant, Robert Kinders, Stanley Lipkowitz, Stephen TC Wong, Milind Pore, Stephen M. Hewitt, Daniel W McVicar, Stephen K Anderson, Jenny Chang, Sharon A Glynn, Stefan Ambs, Stephen J. Lockett, David A Wink

Anti-tumor immune polarization is a key predictor of clinical outcomes to cancer therapy. An emerging concept influencing clinical outcome involves the spatial location of CD8+T cells, within the tumor. Our earlier work demonstrated immunosuppressive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ce85bf0985c117fd7beeefce3636977a
https://doi.org/10.1101/2022.06.03.494733

3’UTR-directed, kinase proximal mRNA decay inhibits C/EBPβ phosphorylation/activation to suppress senescence in tumor cells

Autor: Jacqueline Salotti, Baktiar Karim, Sweta Misra, Linshan Hu, Srikanta Basu, Nancy Martin, Brian T. Luke, Karen Saylor, Thorkell Andresson, David A. Scheiblin, Stephen Lockett, Lino Tessarollo, Peter F. Johnson

C/EBPβ is a potent regulator of RAS-induced senescence (RIS) and the SASP. C/EBPβ is post- translationally activated in RIS cells by the effector kinases ERK1/2 and CK2, but in tumor cells activation is suppressed by the CEBPB 3’UTR. 3′UTR regu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::55ed09d3228d7898093bd7b9a2daf8a8
https://doi.org/10.1101/2022.03.29.486281

Tumour irradiation combined with vascular-targeted photodynamic therapy enhances antitumour effects in pre-clinical prostate cancer

Autor: Danny Allen, Stephen J. Lockett, Ruth J. Muschel, Tamar Yechezkel, Paul Kinchesh, Boris Vojnovic, Alastair D. Lamb, Hanna T. Sjoberg, Dina Preise, Richard J. Bryant, Jens Rittscher, Ka Ho Tam, Adrian L. Harris, Ian G. Mills, Yiannis Philippou, Anette L Magnussen, Iain D. C. Tullis, Emma A Murphy, Lilach Agemy, Freddie C. Hamdy, David A. Wink, Andrea Chatrian, Avigdor Scherz, Sean Smart, Joël Lefebvre, Stuart Gilchrist, Esther Bridges, David A. Scheiblin

Publikováno v: Sjoberg, H T, Philippou, Y, Magnussen, A L, Tullis, I D C, Bridges, E, Chatrian, A, Lefebvre, J, Tam, K H, Murphy, E A, Rittscher, J, Preise, D, Agemy, L, Yechezkel, T, Smart, S C, Kinchesh, P, Gilchrist, S, Allen, D P, Scheiblin, D A, Lockett, S J, Wink, D A, Lamb, A D, Mills, I G, Harris, A, Muschel, R J, Vojnovic, B, Scherz, A, Hamdy, F C & Bryant, R J 2021, ' Tumour irradiation combined with vascular-targeted photodynamic therapy enhances antitumour effects in pre-clinical prostate cancer ', British Journal of Cancer, vol. 125, pp. 534-546 . https://doi.org/10.1038/s41416-021-01450-6
British Journal of Cancer

Background There is a need to improve the treatment of prostate cancer (PCa) and reduce treatment side effects. Vascular-targeted photodynamic therapy (VTP) is a focal therapy for low-risk low-volume localised PCa, which rapidly disrupts targeted tum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95e332f7007516e12e8126b136968964
https://pure.qub.ac.uk/en/publications/tumour-irradiation-combined-with-vasculartargeted-photodynamic-therapy-enhances-antitumour-effects-in-preclinical-prostate-cancer(a26d16da-6c3f-41e3-84f7-b20bf56280b2).html