Zobrazeno 1 - 10
of 14
pro vyhledávání: '"David A, Mallett"'
Autor:
Sebastien Andre Campos, Sorif Uddin, Daniel Thomas, Paul Rowland, Birgit Duempelfeld, Douglas W. Thomson, Andrew Sharpe, James E. Rowedder, Kenneth David Down, Máire A. Convery, Augustin Amour, Michael Daniel Goldsmith, Grant A. McGonagle, David N. Mallett, Edith M. Hessel, Jana Krause, Kevin James Doyle, J. Nicole Hamblin, Srividya Sriskantharajah, Edward P. Cannons, Vipulkumar Kantibhai Patel, Chris D. Edwards, Cole Clissold, Nick Barton, Anderson Niall Andrew, John J. Coward
Publikováno v:
Journal of medicinal chemistry. 64(18)
Optimization of a previously reported lead series of PI3Kδ inhibitors with a novel binding mode led to the identification of a clinical candidate compound 31 (GSK251). Removal of an embedded Ames-positive heteroaromatic amine by reversing a sulfonam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acd30d2dabfe0764f96af2bbb1bd2724
https://pubmed.ncbi.nlm.nih.gov/34510892
https://pubmed.ncbi.nlm.nih.gov/34510892
Autor:
Giovanna Bergamini, Stefano Livia, Kenneth David Down, Marcus Bantscheff, Nick Barton, Friedrich B M Reinhard, Paola Grandi, Daniel Thomas, David N. Mallett, Paul Martin Gore, Sophie M. Bertrand, Z.A. Henley, Edith M. Hessel, James E. Rowedder, Mark Price, J. Nicole Hamblin, Birgit Dümpelfeld, Augustin Amour, Steve Keeling, Christina Rau, Máire A. Convery, Chris D. Edwards, Jonathan A. Taylor, Paul Rowland, Aoife C. Maxwell
Publikováno v:
Journal of Medicinal Chemistry. 63:638-655
Optimization of a lead series of PI3Kδ inhibitors based on a dihydroisobenzofuran core led to the identification of potent, orally bioavailable compound 19. Selectivity profiling of compound 19 showed similar potency for class III PI3K, Vps34, and P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee509ec4ce8051c7f53718e7e95b2637
https://doi.org/10.1021/acs.jmedchem.9b01585
https://doi.org/10.1021/acs.jmedchem.9b01585
Autor:
Malcolm Begg, Eleni Pefani, Jonathan Clark, Carla F. Newman, Miriam Marotti, Martin I. Hingle, Disala Fernando, David N. Mallett, Anthony Cahn, Sorif Uddin, Filzah Ehtesham, Josie Morrell, Robert Wilson, Giovanni Vitulli, J. Nicole Hamblin, Jane Gilbert, Chris D. Edwards, Edith M. Hessel, Andrew W Harrell
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 369:443-453
This study describes the pharmacokinetic (PK) and pharmaco-dynamic (PD) profile of N-(5-(4-(5-(((2R,6S)-2,6-dimethylmorpholino)methyl)oxazol-2-yl)-1H-indazol-6-yl)-2-methoxypyridin-3-yl)methanesulfonamide (GSK2292767A), a novel low-solubility inhaled
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d458b382120aa5c2397a9f4a956bd6f
https://doi.org/10.1124/jpet.119.257311
https://doi.org/10.1124/jpet.119.257311
Autor:
Máire A. Convery, Daniel Thomas, Chris D. Edwards, Craig Jamieson, James E. Rowedder, Ian Robert Baldwin, David N. Mallett, Chun-wa Chung, Charlotte J. Hardy, Nick Barton, Jonathan A. Spencer, Paul Rowland
Publikováno v:
ACS Med Chem Lett
[Image: see text] A macrocyclization approach has been explored on a series of benzoxazine phosphoinositide 3-kinase δ inhibitors, resulting in compounds with improved potency, permeability, and in vivo clearance while maintaining good solubility. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dbc1735d34e567458cec0c9c2f06956
https://pubmed.ncbi.nlm.nih.gov/32676144
https://pubmed.ncbi.nlm.nih.gov/32676144
Publikováno v:
Infrared Imaging Systems: Design, Analysis, Modeling, and Testing XXIX.
The authors reflect on their three decades in the field of Infrared (IR) projection development and test. This merry group of youngsters had no idea this niche technology would consume them, pit them against each other, and ultimately unite them. Ove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f4c5ddcc8b5bc271540387e59cad403
https://doi.org/10.1117/12.2306156
https://doi.org/10.1117/12.2306156
Autor:
Victoria Weller, Poonam Shah, David N. Mallett, Mark Price, Joanne O. Hessey, Diane M. Coe, Stephen C. Hughes, Charlotte J. Hardy, Amanda Lucas, Xiao Qing Lewell, Doug Ball, Bob H. Gibbon, Stephen A. Smith, Anesh Sitaram, Linos Lazarides, Keith Biggadike, Daphne Tsitoura, Stephen A. Hermitage, Richard Stocker, Chris D. Edwards, Mahbub Ahmed, Diana Quint, Fiona Priest, Deidre Dalmas Wilk, Aimee Hillegas, Naimisha Trivedi
Publikováno v:
Journal of medicinal chemistry. 59(5)
Induction of IFNα in the upper airways via activation of TLR7 represents a novel immunomodulatory approach to the treatment of allergic asthma. Exploration of 8-oxoadenine derivatives bearing saturated oxygen or nitrogen heterocycles in the N-9 subs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bdcda90152809a3ff8a4fd4643ae229
https://pubmed.ncbi.nlm.nih.gov/26861551
https://pubmed.ncbi.nlm.nih.gov/26861551
Autor:
David N. Mallett, Cesar Ramirez-Molina
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 49:100-107
Recent years have seen the introduction of new high performance liquid chromatography (HPLC) instruments and columns that are capable of achieving high resolution, high speed liquid chromatographic separations at back pressures up to 1000 bar, so-cal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21285c6bf5f98575f7f9b0da8099cbf8
https://doi.org/10.1016/j.jpba.2008.09.041
https://doi.org/10.1016/j.jpba.2008.09.041
Autor:
Paul E. Greenberg, Andree-Anne Fournier, Tammy Sisitsky, Crystal T. Pike, Ronald C. Kessler, Benjamin I. Goldstein, Howard G. Birnbaum, Stephanie A. Leong, Sarah W. Lowe, Patricia A. Berglund, Patricia K. Corey-Lisle, Lizheng Shi, Ellison Dial, Emily F. Oster, David A. Mallett, Rebecca L. Robinson, Maryna B. Marynchenko, Ami J. Claxton, Tamar Sisitsky, Stan N. Finkelstein, Ernst R. Berndt, Jonathan R. T. Davidson, James C. Ballenger, Abby J. Fyer, Laura E. Stiglin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57032475752d536e97459b99dbffd1e4
https://doi.org/10.4088/pp.15013foc0
https://doi.org/10.4088/pp.15013foc0
Autor:
David N. Mallett, I M Ismail, H. Young, Andrew D. Roberts, S. A. Bird, R. S. Plumb, David Higton, Gordon J. Dear
Publikováno v:
Chromatographia. 55:177-184
In this paper we investigate the potential of alkyl-bonded silica monolithic columns for the isolation and identification of drug-related components in biological fluids. Up to 6 columns have been connected in series to produce a chromatographic syst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd6123452349aa45ade3188723db212c
https://doi.org/10.1007/bf02492139
https://doi.org/10.1007/bf02492139
Autor:
David N. Mallett, R. A. Biddlecombe, S. Pleasance, Gordon J. Dear, Robert S. Plumb, David Higton
Publikováno v:
Xenobiotica. 31:599-617
1. The development of bio-analysis of drug molecules over the last 10 years is reviewed, focusing on advances in sample preparation, liquid chromatography and detection. 2. Developments have led to improvements in detection sensitivity, enhancements
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74981f6494aaf371321c08fc4c0a4646
https://doi.org/10.1080/00498250110060941
https://doi.org/10.1080/00498250110060941