Zobrazeno 1 - 10
of 1 046
pro vyhledávání: '"David A, Lomas"'
Autor:
Jeffrey H. Teckman, Paula Buchanan, Keith Steven Blomenkamp, Nina Heyer-Chauhan, Keith Burling, David A. Lomas
Publikováno v:
Gastro Hep Advances, Vol 3, Iss 6, Pp 842-850 (2024)
Background and Aims: Children with alpha-1-antitrypsin deficiency (AATD) exhibit a wide range of liver disease outcomes from portal hypertension and transplant to asymptomatic without fibrosis. Individual outcomes cannot be predicted. Liver injury in
Externí odkaz:
https://doaj.org/article/260a905276dd4f2daf38a50bb0057f12
Autor:
Marie‐Christine Bouton, Margarethe Geiger, William P Sheffield, James A Irving, David A Lomas, Sihong Song, Ritvik S Satyanarayanan, Liqiang Zhang, Grant McFadden, Alexandra R Lucas
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 6, Pp 1-5 (2023)
Abstract In the practice of medicine, many fundamental biological pathways that require tight on/off control, such as inflammation and circulatory homeostasis, are regulated by serine proteinases, but we rarely consider the unique protease inhibitors
Externí odkaz:
https://doaj.org/article/9884bec85769492f83aef84706a3bcf0
Autor:
Lystra P. Hayden, Brian D. Hobbs, Robert Busch, Michael H. Cho, Ming Liu, Camila M. Lopes-Ramos, David A. Lomas, Per Bakke, Amund Gulsvik, Edwin K. Silverman, James D. Crapo, Terri H. Beaty, Nan M. Laird, Christoph Lange, Dawn L. DeMeo
Publikováno v:
Respiratory Research, Vol 24, Iss 1, Pp 1-14 (2023)
Abstract Background The association between genetic variants on the X chromosome to risk of COPD has not been fully explored. We hypothesize that the X chromosome harbors variants important in determining risk of COPD related phenotypes and may drive
Externí odkaz:
https://doaj.org/article/71a1f12c51ed4f9e8a3f61b876cf0e2e
Autor:
Preeti Lakshman Kumar, Ava C. Wilson, Alison Rocco, Michael H. Cho, Emily Wan, Brian D. Hobbs, George R. Washko, Victor E. Ortega, Stephanie A. Christenson, Xingnan Li, J. Michael Wells, Surya P. Bhatt, Dawn L. DeMeo, Sharon M. Lutz, Harry Rossiter, Richard Casaburi, Stephen I. Rennard, David A. Lomas, Wassim W. Labaki, Ruth Tal‐Singer, Russel P. Bowler, Craig P. Hersh, Hemant K. Tiwari, Mark Dransfield, Anna Thalacker‐Mercer, Deborah A. Meyers, Edwin K. Silverman, Merry‐Lynn N. McDonald, COPDGene, ECLIPSE and SPIROMICS investigators
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 12, Iss 6, Pp 1803-1817 (2021)
Abstract Background Chronic obstructive pulmonary disease (COPD) is the third leading cause of death globally. COPD patients with cachexia or weight loss have increased risk of death independent of body mass index (BMI) and lung function. We tested t
Externí odkaz:
https://doaj.org/article/bf76ffb6e2b4400fa7635ccceb291578
Development of a small molecule that corrects misfolding and increases secretion of Z α1‐antitrypsin
Autor:
David A Lomas, James A Irving, Christopher Arico‐Muendel, Svetlana Belyanskaya, Andrew Brewster, Murray Brown, Chun‐wa Chung, Hitesh Dave, Alexis Denis, Nerina Dodic, Anthony Dossang, Peter Eddershaw, Diana Klimaszewska, Imran Haq, Duncan S Holmes, Jonathan P Hutchinson, Alistair M Jagger, Toral Jakhria, Emilie Jigorel, John Liddle, Ken Lind, Stefan J Marciniak, Jeff Messer, Margaret Neu, Allison Olszewski, Adriana Ordonez, Riccardo Ronzoni, James Rowedder, Martin Rüdiger, Steve Skinner, Kathrine J Smith, Rebecca Terry, Lionel Trottet, Iain Uings, Steve Wilson, Zhengrong Zhu, Andrew C Pearce
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 3, Pp 1-16 (2021)
Abstract Severe α1‐antitrypsin deficiency results from the Z allele (Glu342Lys) that causes the accumulation of homopolymers of mutant α1‐antitrypsin within the endoplasmic reticulum of hepatocytes in association with liver disease. We have use
Externí odkaz:
https://doaj.org/article/73075a476ae1421891a994ecbcb35e20
Autor:
Alistair M. Jagger, Christopher A. Waudby, James A. Irving, John Christodoulou, David A. Lomas
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
α1-Antitrypsin (AAT) is a 52 kDa serum glycoprotein, the misfolding and polymerisation of which is associated with COPD and liver disease. Here the authors demonstrate the use of high-resolution multidimensional solution-state NMR spectroscopy to ch
Externí odkaz:
https://doaj.org/article/952ff70a4c194a3cb72bb437aed03968
Autor:
Nicola C. Day, Subramanya Kumar, Gerard Criner, Mark Dransfield, David M. G. Halpin, MeiLan K. Han, C. Elaine Jones, Morrys C. Kaisermann, Sally Kilbride, Peter Lange, David A. Lomas, Neil Martin, Fernando J. Martinez, Dave Singh, Robert Wise, David A. Lipson
Publikováno v:
Respiratory Research, Vol 21, Iss 1, Pp 1-12 (2020)
Abstract Background This analysis of the IMPACT study assessed the cardiovascular (CV) safety of single-inhaler triple therapy with fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI) versus FF/VI and UMEC/VI dual therapy. Methods IMPACT was a 5
Externí odkaz:
https://doaj.org/article/bc54e68176db4ca5a7f7fcc01003961a
Autor:
Ava C. Wilson, Preeti L. Kumar, Sool Lee, Margaret M. Parker, Itika Arora, Jarrett D. Morrow, Emiel F. M. Wouters, Richard Casaburi, Stephen I. Rennard, David A. Lomas, Alvar Agusti, Ruth Tal-Singer, Mark T. Dransfield, J. Michael Wells, Surya P. Bhatt, George Washko, Victor J. Thannickal, Hemant K. Tiwari, Craig P. Hersh, Peter J. Castaldi, Edwin K. Silverman, Merry-Lynn N. McDonald
Publikováno v:
Respiratory Research, Vol 21, Iss 1, Pp 1-9 (2020)
Abstract Introduction Cachexia contributes to increased mortality and reduced quality of life in Chronic Obstructive Pulmonary Disease (COPD) and may be associated with underlying gene expression changes. Our goal was to identify differential gene ex
Externí odkaz:
https://doaj.org/article/8fe83349e7e14355b35989dbedb0784d
Autor:
Laurence Vass, Marie Fisk, Joseph Cheriyan, Divya Mohan, Julia Forman, Adelola Oseni, Anand Devaraj, Kaisa M. Mäki-Petäjä, Carmel M. McEniery, Jonathan Fuld, Nicholas S. Hopkinson, David A. Lomas, John R. Cockcroft, Ruth Tal-Singer, Michael I. Polkey, Ian B. Wilkinson
Publikováno v:
ERJ Open Research, Vol 7, Iss 3 (2021)
Rationale COPD and smoking are characterised by pulmonary inflammation. 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) imaging may improve knowledge of pulmonary inflammation in COPD patients and aid early develo
Externí odkaz:
https://doaj.org/article/58b7ac41c79543efbd700168d5af6a88
Autor:
Merry-Lynn N. McDonald, Emiel F. M. Wouters, Erica Rutten, Richard Casaburi, Stephen I. Rennard, David A. Lomas, Marcas Bamman, Bartolome Celli, Alvar Agusti, Ruth Tal-Singer, Craig P. Hersh, Mark Dransfield, Edwin K. Silverman
Publikováno v:
Respiratory Research, Vol 20, Iss 1, Pp 1-9 (2019)
Abstract Background Cachexia is associated with increased mortality risk among chronic obstructive pulmonary disease (COPD) patients. However, low body mass index (BMI) as opposed to cachexia is often used, particularly when calculating the BODE (BMI
Externí odkaz:
https://doaj.org/article/1c85ba11211d49cea84cde762645e8ec