Zobrazeno 1 - 10
of 116
pro vyhledávání: '"David A, Hormuth"'
Autor:
Hugo J. M. Miniere, Ernesto A. B. F. Lima, Guillermo Lorenzo, David A. Hormuth II, Sophia Ty, Amy Brock, Thomas E. Yankeelov
Publikováno v:
Cancer Biology & Therapy, Vol 25, Iss 1 (2024)
ABSTRACTTumor heterogeneity contributes significantly to chemoresistance, a leading cause of treatment failure. To better personalize therapies, it is essential to develop tools capable of identifying and predicting intra- and inter-tumor heterogenei
Externí odkaz:
https://doaj.org/article/0e280a58802b47fcb80eb711f4c69ab3
Autor:
Jianchen Yang, Jack Virostko, Junyan Liu, Angela M. Jarrett, David A. Hormuth, Thomas E. Yankeelov
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-18 (2023)
Abstract Glucose plays a central role in tumor metabolism and development and is a target for novel therapeutics. To characterize the response of cancer cells to blockade of glucose uptake, we collected time-resolved microscopy data to track the grow
Externí odkaz:
https://doaj.org/article/df4fe1d9799942a9801f98eb223ad66c
Autor:
Emel Alkim, Heidi Dowst, Julie DiCarlo, Lacey E. Dobrolecki, Anadulce Hernández-Herrera, David A. Hormuth, Yuxing Liao, Apollo McOwiti, Robia Pautler, Mothaffar Rimawi, Ashley Roark, Ramakrishnan Rajaram Srinivasan, Jack Virostko, Bing Zhang, Fei Zheng, Daniel L. Rubin, Thomas E. Yankeelov, Michael T. Lewis
Publikováno v:
Tomography, Vol 9, Iss 2, Pp 810-828 (2023)
Co-clinical trials are the concurrent or sequential evaluation of therapeutics in both patients clinically and patient-derived xenografts (PDX) pre-clinically, in a manner designed to match the pharmacokinetics and pharmacodynamics of the agent(s) us
Externí odkaz:
https://doaj.org/article/e0d87f8b7a8e4f92951123a867d724ef
Autor:
Chase Christenson, Chengyue Wu, David A. Hormuth, II, Shiliang Huang, Ande Bao, Andrew Brenner, Thomas E. Yankeelov
Publikováno v:
Brain Multiphysics, Vol 5, Iss , Pp 100084- (2023)
Rhenium-186 (186Re) labeled nanoliposome (RNL) therapy for recurrent glioblastoma patients has shown promise to improve outcomes by locally delivering radiation to affected areas. To optimize the delivery of RNL, we have developed a framework to pred
Externí odkaz:
https://doaj.org/article/1176bf43f8224916b4901975af7a052c
Autor:
Anirban Chaudhuri, Graham Pash, David A. Hormuth, Guillermo Lorenzo, Michael Kapteyn, Chengyue Wu, Ernesto A. B. F. Lima, Thomas E. Yankeelov, Karen Willcox
Publikováno v:
Frontiers in Artificial Intelligence, Vol 6 (2023)
We develop a methodology to create data-driven predictive digital twins for optimal risk-aware clinical decision-making. We illustrate the methodology as an enabler for an anticipatory personalized treatment that accounts for uncertainties in the und
Externí odkaz:
https://doaj.org/article/0033dc2ccbbf4cf4b2bfb36a88972137
Autor:
Seth T. Gammon, Allison S. Cohen, Adrienne L. Lehnert, Daniel C. Sullivan, Dariya Malyarenko, Henry Charles Manning, David A. Hormuth, Heike E. Daldrup-Link, Hongyu An, James D. Quirk, Kooresh Shoghi, Mark David Pagel, Paul E. Kinahan, Robert S. Miyaoka, A. McGarry Houghton, Michael T. Lewis, Peder Larson, Renuka Sriram, Stephanie J. Blocker, Stephen Pickup, Alexandra Badea, Cristian T. Badea, Thomas E. Yankeelov, Thomas L. Chenevert
Publikováno v:
Tomography, Vol 9, Iss 2, Pp 750-758 (2023)
Providing method descriptions that are more detailed than currently available in typical peer reviewed journals has been identified as an actionable area for improvement. In the biochemical and cell biology space, this need has been met through the c
Externí odkaz:
https://doaj.org/article/987d12f93c464f0385e654e3a94d2678
Autor:
Kalina P. Slavkova, Sahil H. Patel, Zachary Cacini, Anum S. Kazerouni, Andrea L. Gardner, Thomas E. Yankeelov, David A. Hormuth
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Tumors exhibit high molecular, phenotypic, and physiological heterogeneity. In this effort, we employ quantitative magnetic resonance imaging (MRI) data to capture this heterogeneity through imaging-based subregions or “habitats” in a mu
Externí odkaz:
https://doaj.org/article/e4c2fdf06bfc4f838320e337ce9f895f
Publikováno v:
Mathematical Biosciences and Engineering, Vol 20, Iss 1, Pp 318-336 (2023)
We incorporate a practical data assimilation methodology into our previously established experimental-computational framework to predict the heterogeneous response of glioma cells receiving fractionated radiation treatment. Replicates of 9L and C6 gl
Externí odkaz:
https://doaj.org/article/e85280bb30994daaa10c36424e4fd53a
Akademický článek
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Autor:
Inês G. Gonçalves, David A. Hormuth II, Sandhya Prabhakaran, Caleb M. Phillips, José Manuel García-Aznar
Publikováno v:
GigaByte (2023)
In silico models of biological systems are usually very complex and rely on a large number of parameters describing physical and biological properties that require validation. As such, parameter space exploration is an essential component of computat
Externí odkaz:
https://doaj.org/article/f90f461679d74dbda156ada805b00c53