Zobrazeno 1 - 10
of 550
pro vyhledávání: '"David A, Hafler"'
Autor:
Qingqi Lin, Yair Dorsett, Ali Mirza, Helen Tremlett, Laura Piccio, Erin E. Longbrake, Siobhan Ni Choileain, David A. Hafler, Laura M. Cox, Howard L. Weiner, Takashi Yamamura, Kun Chen, Yufeng Wu, Yanjiao Zhou
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-13 (2024)
Abstract Background Previous studies have identified a diverse group of microbial taxa that differ between patients with multiple sclerosis (MS) and the healthy population. However, interpreting findings on MS-associated microbiota is challenging, as
Externí odkaz:
https://doaj.org/article/fdb2ecafbcc14cf782be9fc55e5cfd28
Autor:
Al Ozonoff, Naresh Doni Jayavelu, Shanshan Liu, Esther Melamed, Carly E. Milliren, Jingjing Qi, Linda N. Geng, Grace A. McComsey, Charles B. Cairns, Lindsey R. Baden, Joanna Schaenman, Albert C. Shaw, Hady Samaha, Vicki Seyfert-Margolis, Florian Krammer, Lindsey B. Rosen, Hanno Steen, Caitlin Syphurs, Ravi Dandekar, Casey P. Shannon, Rafick P. Sekaly, Lauren I. R. Ehrlich, David B. Corry, Farrah Kheradmand, Mark A. Atkinson, Scott C. Brakenridge, Nelson I. Agudelo Higuita, Jordan P. Metcalf, Catherine L. Hough, William B. Messer, Bali Pulendran, Kari C. Nadeau, Mark M. Davis, Ana Fernandez Sesma, Viviana Simon, Harm van Bakel, Seunghee Kim-Schulze, David A. Hafler, Ofer Levy, Monica Kraft, Chris Bime, Elias K. Haddad, Carolyn S. Calfee, David J. Erle, Charles R. Langelier, Walter Eckalbar, Steven E. Bosinger, IMPACC Network, Bjoern Peters, Steven H. Kleinstein, Elaine F. Reed, Alison D. Augustine, Joann Diray-Arce, Holden T. Maecker, Matthew C. Altman, Ruth R. Montgomery, Patrice M. Becker, Nadine Rouphael
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Post-acute sequelae of SARS-CoV-2 (PASC) is a significant public health concern. We describe Patient Reported Outcomes (PROs) on 590 participants prospectively assessed from hospital admission for COVID-19 through one year after discharge. M
Externí odkaz:
https://doaj.org/article/ec0ddc29cd90460ca1ec27bea2b831b8
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-17 (2023)
Abstract Many deep learning-based methods have been proposed to handle complex single-cell data. Deep learning approaches may also prove useful to jointly analyze single-cell RNA sequencing (scRNA-seq) and single-cell T cell receptor sequencing (scTC
Externí odkaz:
https://doaj.org/article/cc49e7a6731d4fb8b1659da3f467e6bc
Autor:
Ho-Joon Lee, Yujiao Zhao, Ira Fleming, Sameet Mehta, Xiaomei Wang, Brent Vander Wyk, Shannon E. Ronca, Heather Kang, Chih-Hung Chou, Benoit Fatou, Kinga K. Smolen, Ofer Levy, Clary B. Clish, Ramnik J. Xavier, Hanno Steen, David A. Hafler, J. Christopher Love, Alex K. Shalek, Leying Guan, Kristy O. Murray, Steven H. Kleinstein, Ruth R. Montgomery
Publikováno v:
iScience, Vol 26, Iss 12, Pp 108387- (2023)
Summary: Infection with West Nile virus (WNV) drives a wide range of responses, from asymptomatic to flu-like symptoms/fever or severe cases of encephalitis and death. To identify cellular and molecular signatures distinguishing WNV severity, we empl
Externí odkaz:
https://doaj.org/article/22004309d1e84b60bb1a70a582178024
Autor:
Hiromitsu Asashima, Dongjoo Kim, Kaicheng Wang, Nikhil Lele, Nicholas C. Buitrago-Pocasangre, Rachel Lutz, Isabella Cruz, Khadir Raddassi, William E. Ruff, Michael K. Racke, JoDell E. Wilson, Tara S. Givens, Alba Grifoni, Daniela Weiskopf, Alessandro Sette, Steven H. Kleinstein, Ruth R. Montgomery, Albert C. Shaw, Fangyong Li, Rong Fan, David A. Hafler, Mary M. Tomayko, Erin E. Longbrake
Publikováno v:
JCI Insight, Vol 8, Iss 16 (2023)
BACKGROUND While B cell depletion is associated with attenuated antibody responses to SARS-CoV-2 mRNA vaccination, responses vary among individuals. Thus, elucidating the factors that affect immune responses after repeated vaccination is an important
Externí odkaz:
https://doaj.org/article/b06e7d12199f424e988db974eca28074
Autor:
Rihao Qu, Yuval Kluger, Junchen Yang, Jun Zhao, David A. Hafler, Diane S. Krause, Alexey Bersenev, Marcus Bosenberg, Michael Hurwitz, Liliana Lucca, Harriet M. Kluger
Publikováno v:
Molecular Cancer, Vol 21, Iss 1, Pp 1-6 (2022)
Abstract Adoptive cell therapy (ACT) using tumor infiltrating lymphocytes (TIL) is being studied in multiple tumor types. However, little is known about clonal cell expansion in vitro and persistence of the ACT product in vivo. We performed single-ce
Externí odkaz:
https://doaj.org/article/e09d03f52a094f57b08ab8aaea9a56a2
Autor:
Clara Abraham, Marie E Robert, Harriet M Kluger, Lilach Aizenbud, Kevan C Herold, Matthew R Austin, Jacqueline E Mann, Ross D Merkin, Liliana Lucca, Badr Al Bawardy, Khadir Raddassi, Nikhil S Joshi, David A Hafler
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 8 (2023)
Immune checkpoint inhibitors (ICIs) are increasingly being used to manage multiple tumor types. Unfortunately, immune-related adverse events affect up to 60% of recipients, often leading to treatment discontinuation in settings where few alternative
Externí odkaz:
https://doaj.org/article/9756494ca35a45cda13db78f98f7441b
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Maintenance of peripheral tolerance by CD4+Foxp3+ regulatory T cells (Tregs) is essential for regulating autoreactive T cells. The loss of function of Foxp3 leads to autoimmune disease in both animals and humans. An example is the rare, X-linked rece
Externí odkaz:
https://doaj.org/article/2c9a35909b0f40d29dd58757c28a02a4
Autor:
Avraham Unterman, Tomokazu S. Sumida, Nima Nouri, Xiting Yan, Amy Y. Zhao, Victor Gasque, Jonas C. Schupp, Hiromitsu Asashima, Yunqing Liu, Carlos Cosme, Wenxuan Deng, Ming Chen, Micha Sam Brickman Raredon, Kenneth B. Hoehn, Guilin Wang, Zuoheng Wang, Giuseppe DeIuliis, Neal G. Ravindra, Ningshan Li, Christopher Castaldi, Patrick Wong, John Fournier, Santos Bermejo, Lokesh Sharma, Arnau Casanovas-Massana, Chantal B. F. Vogels, Anne L. Wyllie, Nathan D. Grubaugh, Anthony Melillo, Hailong Meng, Yan Stein, Maksym Minasyan, Subhasis Mohanty, William E. Ruff, Inessa Cohen, Khadir Raddassi, The Yale IMPACT Research Team, Laura E. Niklason, Albert I. Ko, Ruth R. Montgomery, Shelli F. Farhadian, Akiko Iwasaki, Albert C. Shaw, David van Dijk, Hongyu Zhao, Steven H. Kleinstein, David A. Hafler, Naftali Kaminski, Charles S. Dela Cruz
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-23 (2022)
SARS-CoV-2 infection can lead to progressive pathology in patients with COVID-19, but information for this disease progression is sparse. Here the authors use multi-omics approach to profile the immune responses of patients, assessing immune repertoi
Externí odkaz:
https://doaj.org/article/071dfec07b41418ab54ed9c36dc0d83e
Autor:
Hiromitsu Asashima, Pierre-Paul Axisa, Thi Hong Giang Pham, Erin E. Longbrake, William E. Ruff, Nikhil Lele, Inessa Cohen, Khadir Raddassi, Tomokazu S. Sumida, David A. Hafler
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 20 (2022)
B cell depletion in patients with relapsing-remitting multiple sclerosis (RRMS) markedly prevents new MRI-detected lesions and disease activity, suggesting the hypothesis that altered B cell function leads to the activation of T cells driving disease
Externí odkaz:
https://doaj.org/article/0c9d8420a9fe4098b16d60ae27757205