Zobrazeno 1 - 10
of 1 400
pro vyhledávání: '"David A, Davis"'
Autor:
Prashant N. M., John F. Fullard, Tereza Clarence, Deepika Mathur, Clara Casey, Evelyn Hennigan, Marcela Alvia, Joana Krause-Massaguer, Ayled Barreda, David A. Davis, Regina T. Vontell, Susanna P. Garamszegi, Jeffery M. Vance, Lorelle Sang, Michael Chatigny, David Vismer, Barry Landin, David Burstein, Donghoon Lee, Georgios Voloudakis, Sabina Berretta, Vahram Haroutunian, William K. Scott, Jaroslav Bendl, Panos Roussos
Publikováno v:
Scientific Data, Vol 11, Iss 1, Pp 1-9 (2024)
Abstract Parkinson’s Disease (PD) is a debilitating neurodegenerative disorder, characterized by motor and cognitive impairments, that affects >1% of the population over the age of 60. The pathogenesis of PD is complex and remains largely unknown.
Externí odkaz:
https://doaj.org/article/b5a4b7a8fd6b4893a7ad2b40b848ed05
Autor:
Pengfei Dong, Liting Song, Jaroslav Bendl, Ruth Misir, Zhiping Shao, Jonathan Edelstien, David A. Davis, Vahram Haroutunian, William K. Scott, Susanne Acker, Nathan Lawless, Gabriel E. Hoffman, John F. Fullard, Panos Roussos
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Brain region- and cell-specific transcriptomic and epigenomic features are associated with heritability for neuropsychiatric traits, but a systematic view, considering cortical and subcortical regions, is lacking. Here, we provide an atlas o
Externí odkaz:
https://doaj.org/article/d686ee4f494c4e079b4e07921e0b1530
Autor:
Julian D. Dallmeier, Ryan Gober, Regina T. Vontell, Ayled Barreda, Daniel A. Dorfsman, David A. Davis, Xiaoyan Sun, Daniel Brzostowicki, Illiana Bennett, Susanna P. Garamszegi, Connor M. Wander, Todd Cohen, William K. Scott
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
IntroductionSeverity and distribution of aggregated tau and neurofibrillary tangles (NFT) are strongly correlated with the clinical presentation of Alzheimer’s disease (AD). Clearance of aggregated tau could decrease the rate of NFT formation and d
Externí odkaz:
https://doaj.org/article/d606ce4d937341f9881e87e417b730aa
Autor:
Hannah K. Jaeger, David A. Davis, Ashwin Nair, Prabha Shrestha, Alexandra Stream, Amulya Yaparla, Robert Yarchoan
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Epstein-Barr virus (EBV) downregulates immune surface markers to avoid immune recognition. Pomalidomide (Pom) was previously shown to increase immune surface marker expression in EBV-infected tumor cells. We explored the mechanism by which P
Externí odkaz:
https://doaj.org/article/771ce4b7f791411a9936e4e4d4d179d5
Autor:
Regina T. Vontell, Ryan Gober, Julian Dallmeier, Daniel Brzostowicki, Ayled Barreda, Kaj Blennow, Henrik Zetterberg, Hlin Kvartsberg, Sakir Humayun Gultekin, Juan Pablo deRivero Vaccari, Helen M. Bramlett, W. Dalton Dietrich, Robert W. Keane, David A. Davis, Tatjana Rundek, Xiaoyan Sun
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 10, Iss 1, Pp n/a-n/a (2024)
Abstract INTRODUCTION Neurogranin (Ng) is considered a biomarker for synaptic dysfunction in Alzheimer's disease (AD). In contrast, the inflammasome complex has been shown to exacerbate AD pathology. METHODS We investigated the protein expression, mo
Externí odkaz:
https://doaj.org/article/b004ddac02d747e7a1752bb243a63c79
Autor:
Prabha Shrestha, Yana Astter, David A. Davis, Ting Zhou, Constance M. Yuan, Ramya Ramaswami, Hao-Wei Wang, Kathryn Lurain, Robert Yarchoan
Publikováno v:
OncoImmunology, Vol 12, Iss 1 (2023)
ABSTRACTPrimary effusion lymphoma (PEL), an aggressive non-Hodgkin lymphoma caused by Kaposi sarcoma-associated herpesvirus (KSHV), lacks standard therapy and has a median survival of 10–22 months with combination chemotherapy. PEL is a tumor of pl
Externí odkaz:
https://doaj.org/article/180683e63907413383b719de45e83eee
Autor:
Susanna P. Garamszegi, Sandra Anne Banack, Linda L. Duque, James S. Metcalf, Elijah W. Stommel, Paul Alan Cox, David A. Davis
Publikováno v:
Toxicology Reports, Vol 10, Iss , Pp 87-96 (2023)
Introduction: Cyanobacterial blooms produce toxins that may become aerosolized, increasing health risks through inhalation exposures. Health related effects on the lower respiratory tract caused by these toxins are becoming better understood. However
Externí odkaz:
https://doaj.org/article/2b14a4bd0187461c81a78f2378726314
Autor:
Susanna P. Garamszegi, Daniel J. Brzostowicki, Thomas M. Coyne, Regina T. Vontell, David A. Davis
Publikováno v:
Toxins, Vol 16, Iss 1, p 42 (2024)
Cetaceans are well-regarded as sentinels for toxin exposure. Emerging studies suggest that cetaceans can also develop neuropathological changes associated with neurodegenerative disease. The occurrence of neuropathology makes cetaceans an ideal speci
Externí odkaz:
https://doaj.org/article/0938b2fa54f342818fc60f3a06c3d5d0
Autor:
David A. Davis, Tara Powell
Scarlett O'Hara munched on a radish and vowed never to go hungry again. Vardaman Bundren ate bananas in Faulkner's Jefferson, and the Invisible Man dined on a sweet potato in Harlem. Although food and stories may be two of the most prominent cultural
Autor:
Sheila T. Nagamatsu, Gregory Rompala, Yasmin L. Hurd, Diana L. Núñez-Rios, Janitza L. Montalvo-Ortiz, Traumatic Stress Brain Research Group, Victor E. Alvarez, David Benedek, Alicia Che, Dianne A. Cruz, David A. Davis, Matthew J. Girgenti, Ellen Hoffman, Paul E. Holtzheimer, Bertrand R. Huber, Alfred Kaye, John H. Krystal, Adam T. Labadorf, Terence M. Keane, Mark W. Logue, Ann McKee, Brian Marx, Deborah Mash, Mark W. Miller, Crystal Noller, JM-O, William K. Scott, Paula Schnurr, Thor Stein, Robert Ursano, Douglas E. Williamson, Erika J. Wolf, Keith A. Young
Publikováno v:
Frontiers in Psychiatry, Vol 13 (2023)
IntroductionDNA methylation (DNAm), an epigenetic mechanism, has been associated with opioid use disorder (OUD) in preclinical and human studies. However, most of the studies have focused on DNAm at CpG sites. DNAm at non-CpG sites (mCpHs, where H in
Externí odkaz:
https://doaj.org/article/8e534560e2b9492589d5919efc931441