Zobrazeno 1 - 10
of 292
pro vyhledávání: '"David A, Bushinsky"'
Publikováno v:
Genes and Diseases, Vol 9, Iss 3, Pp 797-806 (2022)
Human idiopathic hypercalciuria (IH) is the most common cause of calcium oxalate nephrolithiasis with perturbed calcium metabolism with increased bone resorption and decreased renal calcium reabsorption, which can be phenotype-copied in the genetic h
Externí odkaz:
https://doaj.org/article/5eb27a15f2bb43df9fcc7b4d47e444a8
Publikováno v:
BMC Nephrology, Vol 23, Iss 1, Pp 1-11 (2022)
Abstract Background Globally, the prevalence of chronic kidney disease (CKD) is higher in women than in men; however, women have been historically under-represented in nephrology clinical trials. Metabolic acidosis increases risk of progressive loss
Externí odkaz:
https://doaj.org/article/97684d1c22f946cbaee05ffc7ba3941b
Publikováno v:
JBMR Plus, Vol 6, Iss 12, Pp n/a-n/a (2022)
ABSTRACT Metabolic acidosis (MET) stimulates bone resorption through inhibition of osteoblast (OB) bone formation and stimulation of osteoclast (OC) bone resorption. We found that OGR1, a G protein‐coupled proton (H+)‐sensing receptor, was critic
Externí odkaz:
https://doaj.org/article/4ed54782ad9244dc836a9eb5fddb98b9
Autor:
David J Jörg, Doris H Fuertinger, Alhaji Cherif, David A Bushinsky, Ariella Mermelstein, Jochen G Raimann, Peter Kotanko
Publikováno v:
eLife, Vol 11 (2022)
For the treatment of postmenopausal osteoporosis, several drug classes with different mechanisms of action are available. Since only a limited set of dosing regimens and drug combinations can be tested in clinical trials, it is currently unclear whet
Externí odkaz:
https://doaj.org/article/cfa893961c024e1bb8eb730ff02f4a99
Publikováno v:
Frontiers in Medicine, Vol 8 (2021)
Background: Personalized management of secondary hyperparathyroidism is a critical part of hemodialysis patient care. We used a mathematical model of parathyroid gland (PTG) biology to predict (1) short-term peridialytic intact PTH (iPTH) changes in
Externí odkaz:
https://doaj.org/article/0c83cc0054cf427cbcb656578aad4380
Autor:
John Cunningham, Geoffrey A. Block, Glenn M. Chertow, Kerry Cooper, Pieter Evenepoel, Jan Iles, Yan Sun, Pablo Ureña-Torres, David A. Bushinsky
Publikováno v:
Kidney International Reports, Vol 4, Iss 7, Pp 987-994 (2019)
Introduction: Calcimimetics improve parameters of secondary hyperparathyroidism (sHPT) but are mostly initiated when patients have severe disease, potentially limiting effectiveness. We evaluated the effects of etelcalcetide on lowering intact parath
Externí odkaz:
https://doaj.org/article/75c4144895a74bd3b6b609e763ea1b01
Autor:
Wei Chen, Jessica Fitzpatrick, Jose M. Monroy-Trujillo, Stephen M. Sozio, Bernard G. Jaar, Michelle M. Estrella, Tong Tong Wu, Michal L. Melamed, Rulan S. Parekh, David A. Bushinsky
Publikováno v:
Kidney International Reports, Vol 4, Iss 6, Pp 806-813 (2019)
Introduction: Magnesium (Mg) may protect against arterial calcification. We tested the hypotheses that a higher serum Mg concentration is associated with less arterial calcification and stiffness in patients on hemodialysis (HD) and that these associ
Externí odkaz:
https://doaj.org/article/cbc07d56b0d2486888fee33b603a0add
Autor:
Nancy S Krieger, Luojing Chen, Jennifer Becker, Sean DeBoyace, Hongwei Wang, Murray J Favus, David A Bushinsky
Publikováno v:
JBMR Plus, Vol 4, Iss 4, Pp n/a-n/a (2020)
ABSTRACT To study human idiopathic hypercalciuria (IH), we developed an animal model, genetic hypercalciuric stone‐forming (GHS) rats, whose pathophysiology parallels that in IH. All GHS rats form kidney stones and have decreased BMD and bone quali
Externí odkaz:
https://doaj.org/article/e8bcd703bba94625975e50dafec8f7a6
Autor:
Donald E. Wesson, Vandana Mathur, Navdeep Tangri, Sarah Hamlett, David A. Bushinsky, L. Ebony Boulware
Publikováno v:
The American Journal of Medicine. 135:1051-1058
Increasing adverse outcomes in patients with chronic kidney disease reflect growth of patients with early-stage chronic kidney disease and their increasing per population rates of these outcomes. Progression of chronic kidney disease, more than curre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0b715792b56a7a6c8727e3dd4edc513
https://doi.org/10.1016/j.amjmed.2022.04.015
https://doi.org/10.1016/j.amjmed.2022.04.015
Autor:
Navdeep Tangri, Vandana Mathur, Nancy L Reaven, Susan E Funk, Reid H Whitlock, Donald E Wesson, David A Bushinsky
Publikováno v:
Clinical Kidney Journal.
Background Epidemiological studies demonstrate an association between kidney stones and risk of chronic kidney disease (CKD) and CKD progression. Metabolic acidosis, as a consequence of CKD, results in a reduced urine pH which promotes the formation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::343ca8d21ce075b0536ab780de5a2ecf
https://doi.org/10.1093/ckj/sfad034
https://doi.org/10.1093/ckj/sfad034