Zobrazeno 1 - 10
of 4 139
pro vyhledávání: '"David A, Baker"'
Autor:
Brian M. Worthington, Portia Y.-H. Wong, Kishoree K. Kumaree, Tracey-Leigh Prigge, Kar Hon Ng, Yunshi Liao, Paolo Martelli, Sarah Churgin, Foo K. Lee, Chris Perkins, Michael Bradley, Mac P. Pierce, Marcus H.-H. Shum, Elliott F. Miot, William Y.-M. Cheung, Shelby E. McIlroy, Helen C. Nash, Wirdateti, Gono Semiadi, Chee-Wah Tan, Lin-Fa Wang, Gary Ades, David M. Baker, Caroline Dingle, Oliver G. Pybus, Edward C. Holmes, Gabriel M. Leung, Yi Guan, Huachen Zhu, Timothy C. Bonebrake, Tommy T. Y. Lam
Publikováno v:
BMC Biology, Vol 22, Iss 1, Pp 1-15 (2024)
Abstract Background Early in the coronavirus disease 2019 (COVID-19) pandemic, Sunda pangolins (Manis javanica) involved in the illegal wildlife trade in mainland China were identified as hosts of severe acute respiratory syndrome-related coronavirus
Externí odkaz:
https://doaj.org/article/91be7ec55eda4cb8aef9dacbe38c1d73
Autor:
Avnish Patel, Aline Fréville, Joshua A. Rey, Helen R. Flynn, Konstantinos Koussis, Mark J. Skehel, Michael J. Blackman, David A. Baker
Publikováno v:
mBio, Vol 15, Iss 11 (2024)
ABSTRACT We previously reported that the Plasmodium falciparum putative serine/threonine protein phosphatase 7 (PP7) is a high-confidence substrate of the cAMP-dependent protein kinase (PKA). Here we explore the function of PP7 in asexual P. falcipar
Externí odkaz:
https://doaj.org/article/8e1daffe95784ff5ad6aba222b2a6941
Autor:
Konstantinos Koussis, Silvia Haase, Chrislaine Withers-Martinez, Helen R Flynn, Simone Kunzelmann, Evangelos Christodoulou, Fairouz Ibrahim, Mark Skehel, David A Baker, Michael J Blackman
Publikováno v:
PLoS Pathogens, Vol 20, Iss 6, p e1012360 (2024)
The cGMP-dependent protein kinase (PKG) is the sole cGMP sensor in malaria parasites, acting as an essential signalling hub to govern key developmental processes throughout the parasite life cycle. Despite the importance of PKG in the clinically rele
Externí odkaz:
https://doaj.org/article/b62bcb1860a84ec8b769e6b711c15964
Autor:
Aline Freville, Lindsay B. Stewart, Kevin K. A. Tetteh, Moritz Treeck, Alfred Cortes, Till S. Voss, Sarah J. Tarr, David A. Baker, David J. Conway
Publikováno v:
mBio, Vol 15, Iss 5 (2024)
ABSTRACTThe Plasmodium falciparum merozoite surface protein MSPDBL2 is a polymorphic antigen targeted by acquired immune responses, and normally expressed in only a minority of mature schizonts. The potential relationship of MSPDBL2 to sexual commitm
Externí odkaz:
https://doaj.org/article/a3c074ac2bf04bf99c760a62f54b71a2
Publikováno v:
Ecological Indicators, Vol 160, Iss , Pp 111683- (2024)
Coastal marine ecosystems are integral in providing numerous ecosystem functions and services. However, intense and chronic anthropogenic stressors often impact marine ecosystems surrounding highly urbanized, densely populated coastal megacities. The
Externí odkaz:
https://doaj.org/article/3aa1d849cb9843659cdb5c80bda5524e
Autor:
Alexandra S. Gardner, David J. Baker, Jonathan R. Mosedale, Kevin J. Gaston, Ilya M. D. Maclean
Publikováno v:
Conservation Letters, Vol 16, Iss 6, Pp n/a-n/a (2023)
Abstract Protected areas (PAs) are a core component in global efforts to prevent further declines in biodiversity. We examine whether the United Kingdom's PA portfolio has reduced local extinctions of breeding birds and consider how the characteristi
Externí odkaz:
https://doaj.org/article/266a943dc2114f398656d59c813afe37
Autor:
David R. Baker, MD, Helen Mac, MD, Benjamin Steinman, MD, Sara H. Soshnick, DO, MS, Shalom Z. Frager, MD, Beatrice Goilav, MD, Debora Kogan-Liberman, MD, Nadia Ovchinsky, MD, MBA, Mark Shlomovich, MD
Publikováno v:
Critical Care Explorations, Vol 5, Iss 11, p e1002 (2023)
IMPORTANCE:. Acute liver failure (ALF) carries significant morbidity and mortality, for both pediatric and adult patients. Albumin dialysis via the molecular adsorbent recirculating system (MARS) is a form of extracorporeal liver support (ELS) that c
Externí odkaz:
https://doaj.org/article/e6ecd36279104f7e93b72abc29a4bf03
Autor:
Jonathan D. Cybulski, Kit Sum Leung, Carmen Oi Ning Leung, David M. Baker, Terence Kin Wah Lee
Publikováno v:
STAR Protocols, Vol 4, Iss 3, Pp 102506- (2023)
Summary: Cholesterol biosynthesis supports proliferation and drives resistance to tyrosine kinase inhibitor (TKI) therapy in hepatocellular carcinoma (HCC). Here, we present a protocol for using stable isotopic tracers to track the biosynthesis of ch
Externí odkaz:
https://doaj.org/article/aece1a8784524daf96df78805392605a
Autor:
Robert E Kennedy, Shawn P Serbin, Michael C Dietze, Hans-Erik Andersen, Chad Babcock, David F Baker, Molly E Brown, Kenneth J Davis, Laura Duncanson, Sha Feng, Andrew T Hudak, Junjie Liu, Paul L Patterson, Brett Raczka, Mark A Cochrane, Edil A Sepúlveda Carlo, Rodrigo Vargas
Publikováno v:
Environmental Research Letters, Vol 19, Iss 12, p 123003 (2024)
Navigating uncertainty is a critical challenge in all fields of science, especially when translating knowledge into real-world policies or management decisions. However, the wide variance in concepts and definitions of uncertainty across scientific f
Externí odkaz:
https://doaj.org/article/2dc720ea66cb44628c9468c74088974d
Autor:
Hui Chen, Wei He, Jinxiu Liu, Ngoc Tu Nguyen, Frédéric Chevallier, Hua Yang, Yiming Lv, Chengcheng Huang, Christian Rödenbeck, Scot M Miller, Fei Jiang, Junjie Liu, Matthew S Johnson, Sajeev Philip, Zhiqiang Liu, Ning Zeng, Sourish Basu, David F Baker
Publikováno v:
Environmental Research Letters, Vol 19, Iss 5, p 054047 (2024)
Southwestern North America (SWNA) continuously experienced megadroughts and large wildfires in 2020 and 2021. Here, we quantified their impact on the terrestrial carbon budget using net biome production (NBP) estimates from an ensemble of atmospheric
Externí odkaz:
https://doaj.org/article/b21316d667fc42df9feb000487b26e19