Zobrazeno 1 - 10
of 10 187 828
pro vyhledávání: '"David A"'
Autor:
Chengjie Xiong, Jingqin Luo, David A. Wolk, Leslie M. Shaw, Erik D. Roberson, Charles F. Murchison, Rachel L. Henson, Tammie L. S. Benzinger, Quoc Bui, Folasade Agboola, Elizabeth Grant, Emily N. Gremminger, Krista L. Moulder, David S. Geldmacher, Olivio J. Clay, Ganesh Babulal, Carlos Cruchaga, David M. Holtzman, Randall J. Bateman, John C. Morris, Suzanne E. Schindler
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Blood-based biomarkers of Alzheimer disease (AD) may facilitate testing of historically under-represented groups. The Study of Race to Understand Alzheimer Biomarkers (SORTOUT-AB) is a multi-center longitudinal study to compare AD biomarkers
Externí odkaz:
https://doaj.org/article/7e17f1f8091f4e35b67e41ede981da17
Autor:
Bam D. Paneru, Julia Chini, Sam J. McCright, Nicole DeMarco, Jessica Miller, Leonel D. Joannas, Jorge Henao-Mejia, Paul M. Titchenell, David M. Merrick, Hee-Woong Lim, Mitchell A. Lazar, David A. Hill
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Adipose tissue macrophages (ATMs) influence obesity-associated metabolic dysfunction, but the mechanisms by which they do so are not well understood. We show that miR-6236 is a bona fide miRNA that is secreted by ATMs during obesity. Global
Externí odkaz:
https://doaj.org/article/c8f82a79f5c0480ab908f0500c2bbc29
Autor:
Lydia Flett, Radwa Abdelatif, Sarah Akhtar Baz, Samantha Brady, Belén Corbacho, Kate Common, Abbie Cowling, Caroline Fairhurst, Ellie Fitzmaurice, Shreyans Gandhi, Andrea Hilton, William Hope, Alex Howard, Joanne Laycock, Patrick Lillie, Gemma Mitchell, Adwoa Parker, Mary Peel, Laura Sheard, Jacqueline Sneddon, Thomas Taynton, Puvan Tharmanathan, David Torgerson, Han-I Wang, David Allsup, Gavin Barlow
Publikováno v:
Trials, Vol 25, Iss 1, Pp 1-23 (2024)
Abstract Background Acute leukaemias (AL) are life-threatening blood cancers that can be potentially cured with treatment involving myelosuppressive, multiagent, intensive chemotherapy (IC). However, such treatment is associated with a risk of seriou
Externí odkaz:
https://doaj.org/article/d5e78be4af574ce5bfc285fc48d4a353
Autor:
David Bar-Or, Stephanie Jarvis, Forrester Lensing, David Bassa, Matthew Carrick, Carlos Palacio Lascano, Maxwell Busch, David Hamilton, David Acuna, Samantha Greenseid, Daniel Ojala
Publikováno v:
Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, Vol 32, Iss 1, Pp 1-14 (2024)
Abstract Background Limited research has explored the effect of Circle of Willis (CoW) anatomy among blunt cerebrovascular injuries (BCVI) on outcomes. It remains unclear if current BCVI screening and scanning practices are sufficient in identificati
Externí odkaz:
https://doaj.org/article/4b48dbbefa7b480695461de8e1287fb5
Autor:
Calum Lindsay, David Baruffati, Mhairi Mackenzie, David A. Ellis, Michelle Major, Catherine A. O’Donnell, Sharon A. Simpson, Andrea E. Williamson, Geoff Wong
Publikováno v:
BMC Medicine, Vol 22, Iss 1, Pp 1-13 (2024)
Abstract Background Although missed appointments in healthcare have been an area of concern for policy, practice and research, the primary focus has been on reducing single ‘situational’ missed appointments to the benefit of services. Little atte
Externí odkaz:
https://doaj.org/article/c37a6e5392ac444a9d3a95b8851ffc09
Autor:
Serafima Dubnov, Estelle R. Bennett, Nadav Yayon, Or Yakov, David A. Bennett, Sudha Seshadri, Elliott Mufson, Yonat Tzur, David Greenberg, Makoto Kuro-o, Iddo Paldor, Carmela R. Abraham, Hermona Soreq
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-14 (2024)
Abstract Overexpression of the longevity gene Klotho prolongs lifespan, while its knockout shortens lifespan and impairs cognition via perturbation of myelination and synapse formation. However, comprehensive analysis of Klotho knockout effects on ma
Externí odkaz:
https://doaj.org/article/3ebc2e4dc2b14899a640933ae8c12b98
Autor:
Sadhana Ravikumar, Amanda E. Denning, Sydney Lim, Eunice Chung, Niyousha Sadeghpour, Ranjit Ittyerah, Laura E. M. Wisse, Sandhitsu R. Das, Long Xie, John L. Robinson, Theresa Schuck, Edward B. Lee, John A. Detre, M. Dylan Tisdall, Karthik Prabhakaran, Gabor Mizsei, Maria Mercedes Iñiguez de Onzono Martin, Maria del Mar Arroyo Jiménez, Monica Mũnoz, Maria del Pilar Marcos Rabal, Sandra Cebada Sánchez, José Carlos Delgado González, Carlos de la Rosa Prieto, David J. Irwin, David A. Wolk, Ricardo Insausti, Paul A. Yushkevich
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Our current understanding of the spread and neurodegenerative effects of tau neurofibrillary tangles (NFTs) within the medial temporal lobe (MTL) during the early stages of Alzheimer’s Disease (AD) is limited by the presence of confounding
Externí odkaz:
https://doaj.org/article/056f36ce471b4eba989dc86723aa6f3b
Autor:
Pantelitsa Dimitriou, Jin Li, William David Jamieson, Johannes Josef Schneider, Oliver Kieran Castell, David Anthony Barrow
Publikováno v:
Communications Chemistry, Vol 7, Iss 1, Pp 1-10 (2024)
Abstract Droplet Interface Bilayers (DIBs) constitute a commonly used model of artificial membranes for synthetic biology research applications. However, their practical use is often limited by their requirement to be surrounded by oil. Here we demon
Externí odkaz:
https://doaj.org/article/29285ef2304e4d59a7da2ee973598083
Autor:
Pragadesh Natarajan, Ashley Lim Cha Yin, R. Dineth Fonseka, David Abi-Hanna, Kaitlin Rooke, Luke Sy, Monish Maharaj, David Broe, Lianne Koinis, Ralph Jasper Mobbs
Publikováno v:
Surgical Techniques Development, Vol 13, Iss 2, Pp 178-191 (2024)
Background. Knee and hip arthroplasty are two of the most frequently performed procedures in orthopaedic surgery. They are associated with positive patient-reported outcomes and significant improvements in quality of life for patients. Despite this,
Externí odkaz:
https://doaj.org/article/2a6333216f3844699453cdd2fbe56ce3
Autor:
Elk Kossatz, Rebeca Diez-Alarcia, Supriya A. Gaitonde, Carla Ramon-Duaso, Tomasz Maciej Stepniewski, David Aranda-Garcia, Itziar Muneta-Arrate, Elodie Tepaz, Suwipa Saen-Oon, Robert Soliva, Aida Shahraki, David Moreira, Jose Brea, Maria Isabel Loza, Rafael de la Torre, Peter Kolb, Michel Bouvier, J. Javier Meana, Patricia Robledo, Jana Selent
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract G protein-coupled receptors (GPCRs) are sophisticated signaling machines able to simultaneously elicit multiple intracellular signaling pathways upon activation. Complete (in)activation of all pathways can be counterproductive for specific t
Externí odkaz:
https://doaj.org/article/455c7d7ebe814812996e6683dd1c4a42