Dendritic Self-assembled Structures from Therapeutic Charged Pentapeptides

Autor: Karima El Hauadi, Leonor Resina, David Zanuy, Teresa Esteves, Frederico Castelo Ferreira, Maria M. Pérez-Madrigal, Carlos Alemán

Publikováno v: Langmuir. 38:12905-12914

CRENKA [Cys-Arg-(NMe)Glu-Lys-Ala, where (NMe)Glu refers to N-methyl-Glu], an anti-cancer pentapeptide that induces prostate tumor necrosis and significant reduction in tumor growth, was engineered to increase the resistance to endogenous proteases of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81072a0f44cdec72aa747793f437047e
https://doi.org/10.1021/acs.langmuir.2c02010

Effect on the Conformation of a Terminally Blocked, (E) β,γ-Unsaturated δ-Amino Acid Residue Induced by Carbon Methylation

Autor: David Zanuy, Claudio Toniolo, Giulia Marafon, Alessandro Moretto, Carlos Alemán, Marco Crisma

Publikováno v: UPCommons. Portal del coneixement obert de la UPC
Universitat Politècnica de Catalunya (UPC)
Journal of organic chemistry (Online) 85 (2020): 1513–1524. doi:10.1021/acs.joc.9b02544
info:cnr-pdr/source/autori:Giulia Marafon, Alessandro Moretto, David Zanuy, Carlos Alemán, Marco Crisma, Claudio Toniolo/titolo:Effect on the Conformation of a Terminally Blocked, (E) beta,gamma-Unsaturated delta-Amino Acid Residue Induced by Carbon Methylation/doi:10.1021%2Facs.joc.9b02544/rivista:Journal of organic chemistry (Online)/anno:2020/pagina_da:1513/pagina_a:1524/intervallo_pagine:1513–1524/volume:85

Peptides are well-known to play a fundamental therapeutic role and to represent building blocks for numerous useful biomaterials. Stabilizing their active 3D-structure by appropriate modifications remains, however, a challenge. In this study, we have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42cb9cd2de835ecfe8452c9c5c625b4a
https://doi.org/10.1021/acs.joc.9b02544

Aggregation propensity of therapeutic fibrin-homing pentapeptides: insights from experiments and molecular dynamics simulations

Autor: Antonio Palleschi, Paolo Conflitti, Carlos Alemán, Gianfranco Bocchinfuso, David Zanuy, Anna Puiggalí-Jou

Publikováno v: UPCommons. Portal del coneixement obert de la UPC
Universitat Politècnica de Catalunya (UPC)

CREKA (Cys–Arg–Glu–Lys–Ala) and its engineered analogue CRMeEKA, in which Glu has been replaced by N-methyl-Glu to provide resistance against proteolysis, are emerging pentapeptides that were specifically designed to bind fibrin–fibronectin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::addf857f1f6ef1c6c476bbaf5766fb9b
https://pubmed.ncbi.nlm.nih.gov/33165494

Impact of Protein-Polymer Interactions in the Antimicrobial Activity of Lysozyme/Poly(3,4-ethylenedioxythiophene) Biocapacitors

Autor: Carlos Alemán, David Zanuy, Jordi Triguero

Publikováno v: UPCommons. Portal del coneixement obert de la UPC
Universitat Politècnica de Catalunya (UPC)
Recercat. Dipósit de la Recerca de Catalunya
instname

Biocapacitors constructed by combining lysozyme (LYZ) and poly(3,4-ethylenedioxythiophene) (PEDOT) retained the bactericidal activity of the protein when this was encapsulated within the polymeric matrix but lost the antimicrobial behaviour when the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39d415fa47bb197e83c385ac7f328e10
https://doi.org/10.1002/slct.201801956

A molecular dynamics study on glucose molecular recognition by a non-enzymatic selective sensor based on a conducting polymer

Autor: Carlos A. Ferreira, Carlos Alemán, David Zanuy, Georgina Fabregat

Publikováno v: Recercat. Dipósit de la Recerca de Catalunya
instname
UPCommons. Portal del coneixement obert de la UPC
Universitat Politècnica de Catalunya (UPC)

Poly(hydroxymethyl-3,4-ethylendioxythiophene) (PHMeDOT), a very electroactive polythiophene derivative bearing a dioxane ring fused onto the thiophene ring and an exocyclic hydroxymethyl substituent, is able to electrocatalyze the oxidation of glucos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83159e949d459094f2fb91e0e2e194d2
https://pubmed.ncbi.nlm.nih.gov/30932123