A perfusion bioreactor-based 3D model of the subarachnoid space based on a meningeal tissue construct

Autor: Albert Neutzner, Laura Power, Markus Dürrenberger, Hendrik P. N. Scholl, Peter Meyer, Hanspeter E. Killer, David Wendt, Corina Kohler

Publikováno v: Fluids and Barriers of the CNS, Vol 16, Iss 1, Pp 1-14 (2019)

Abstract Background Altered flow of cerebrospinal fluid (CSF) within the subarachnoid space (SAS) is connected to brain, but also optic nerve degenerative diseases. To overcome the lack of suitable in vitro models that faithfully recapitulate the int

Externí odkaz: https://doaj.org/article/835108f5f44545fcbbcd6ea168c140df

Rapid prototyped porous nickel–titanium scaffolds as bone substitutes

Autor: Waldemar Hoffmann, Therese Bormann, Antonella Rossi, Bert Müller, Ralf Schumacher, Ivan Martin, Michael de Wild, David Wendt

Publikováno v: Journal of Tissue Engineering, Vol 5 (2014)

While calcium phosphate–based ceramics are currently the most widely used materials in bone repair, they generally lack tensile strength for initial load bearing. Bulk titanium is the gold standard of metallic implant materials, but does not match

Externí odkaz: https://doaj.org/article/75a9142a55cd4936b6d23807d7b97dda

Biomarker signatures of quality for nasal chondrocyte-derived engineered cartilage

Autor: Andrea Barbero, R. Koeppl, Laura Power, Martin Haug, M. A. Asnaghi, David Wendt, Ivan Martin

The definition of quality controls for cell therapy and engineered product manufacturing processes is critical for safe, effective, and standardized clinical implementation. Using the example context of cartilage grafts engineered from autologous nas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b14d7725478fc97013e59c484986ae16
https://doi.org/10.1101/2020.02.12.945527

Sensing tissue engineered cartilage quality with Raman spectroscopy and statistical learning for the development of advanced characterization assays

Autor: David Wendt, Andrea Barbero, Ivan Martin, M. Adelaide Asnaghi, Laura Power, Anke Wixmerten, Claudia Fasolato

Publikováno v: Biosensors and Bioelectronics

Nasal chondrocyte-derived engineered cartilage has been demonstrated to be safe and feasible for the treatment of focal cartilage lesions with promising preliminary evidences of efficacy. To ensure the quality of the products and processes, and to me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9b33868723a4111e9f0b0950b424522
http://hdl.handle.net/11391/1478389

Bioreactor‐manufactured cartilage grafts repair acute and chronic osteochondral defects in large animal studies

Autor: Lauren Hails, Graziella Pellegrini, Ivan Martin, Maja Pušić, Helen L. Quasnichka, Alan Ivković, Timothy Smith, Christian Krause, Maria Adelaide Asnaghi, Andreja Vukasović, David Wendt, Anke Wixmerten, Elisa Figallo, Wael Kafienah, Petar Kostešić, Giuseppe Filardo, Damir Hudetz, Elizaveta Kon, Nuala Trainor, Drazen Maticic, Carmine Cozzolino

Publikováno v: Vukasovic, A, Asnaghi, M A, Kostesic, P, Quasnichka, H L, Cozzolino, C, Pusic, M, Hails, L, Trainor, N, Krause, C, Figallo, E, Filardo, G, Kon, E, Wixmerten, A, Maticic, D, Pellegrini, G, Kafienah, W, Hudetz, D, Smith, T, Martin, I, Ivkovic, A & Wendt, D 2019, ' Bioreactor manufactured cartilage grafts repair acute and chronic osteochondral defects in large animal studies ', Cell Proliferation . https://doi.org/10.1111/cpr.12653
Cell Proliferation

Objectives Bioreactor-based production systems have the potential to overcome limitations associated with conventional tissue engineering manufacturing methods, facilitating regulatory compliant and cost-effective production of engineered grafts for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16bf6fb4c0050527cd79e91751a67c9e
https://doi.org/10.1111/cpr.12653