Zobrazeno 1 - 10
of 12
pro vyhledávání: '"David W. Hoard"'
Autor:
Marvin M. Hansen, Jennifer Kuehne-Willmore, Amy C. DeBaillie, Molly Harding, Joseph R. Martinelli, Daniel J. Jarmer, Michael J. McCulley, Dominique Huber, Michael E. Laurila, Thomas J. Martin, David W. Hoard, Theo Zweifel, Ryan J. Linder, Stanley P. Kolis, Nikolay Zaborenko, Enver Arslantas, Rachel N. Richey, Derek R. Starkey, Thomas Kull, Adrienne Hollister, Jeffrey A. Ward, Andrea L. Frederick
Publikováno v:
Organic Process Research & Development. 19:1214-1230
An efficient synthesis of LY2886721 (1) in five steps and 46% overall yield from the chiral nitrone cycloadduct 2 is presented. Minimizing formation of a des-fluoro impurity during hydrogenolysis to cleave the isoxazolidine ring and remove the benzyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1db94ba09df24b6c834b9f697582e3e8
https://doi.org/10.1021/op500327t
https://doi.org/10.1021/op500327t
Autor:
Martin Müllner, Kevin A. Sullivan, Michael E. Laurila, Richard D. Miller, Michael Leroy Phillips, Tanja Leitner, Mario Waser, David W. Hoard, Marvin M. Hansen, Chaoyu Xie, Marcus Kordian, Sandy S. K. Borders, Jeffrey A. Ward, Michael E. LeTourneau, Eric D. Moher, Cheryl A. Bye, Brigitte Herzog-Krimbacher
Publikováno v:
Organic Process Research & Development. 15:1266-1274
To fuel clinical development of the experimental CNS medicine LY2140023, we developed a scalable route for the multistep synthesis of a pivotal synthetic intermediate. The core of the conformationally restricted glutamic acid-based amino acid analogu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::864de8e0e1bf7c7dd96cc65b0fc6c539
https://doi.org/10.1021/op100325h
https://doi.org/10.1021/op100325h
Publikováno v:
Organic Letters. 4:1813-1815
[reaction: see text] A synthesis of cryptophycin 52 is reported using a Shi epoxidation strategy to install the epoxide moiety in a diastereoselective fashion. Several epoxidation results for cryptophycin substrates are disclosed followed by a discus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd42ec0a3ccc2734ba8e05de42713ea3
https://doi.org/10.1021/ol025933+
https://doi.org/10.1021/ol025933+
Autor:
David W. Hoard, Paul R. Sharp
Publikováno v:
Inorganic Chemistry. 32:612-620
Treating [Cp[sup *]Rh([mu]-Cl)Cl][sub 2] (Cp[sup *] = C[sub 5]Me[sub 5] = pentamethylcyclopentadienyl) with excess Na(Hg) (0.4%) in CH[sub 2]Cl[sub 2] gives deep blue [Cp[sup *]Rh([mu]-Cl)][sub 2] (1). The structure consists of two independent, nearl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58ef3ffd01fd82fdf7f038512c1682b1
https://doi.org/10.1021/ic00057a021
https://doi.org/10.1021/ic00057a021
Publikováno v:
Organic Process Research & Development. 3:64-66
A simple three-step preparation of (R)-(−)-1-piperidino-3,3-dimethylbutan-2-ol (amino alcohol catalyst for the Noyori asymmetric alkylation of aldehydes) based on a classical resolution of the race...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac93db77c869a671bdc62b1ef5f0a3c8
https://doi.org/10.1021/op980208t
https://doi.org/10.1021/op980208t
Autor:
Ivan Collado, Eric D. Moher, Joseph P. Tizzano, Concepcion Pedregal, David W. Hoard, T. Rosario Gonzalez, Jaime Blanco-Urgoiti, Rebecca A. Wright, Darryle Darwin Schoepp, Javier Pérez-Castells, Kelly I. Griffey, Alicia Marcos, Ana Belén Bueno, Ann E. Kingston, Bryan G. Johnson
Publikováno v:
Journal of medicinal chemistry. 47(2)
The asymmetric synthesis and biological activity of (2S,1‘S,2‘R,3‘R)-2-(2‘-carboxy-3‘-hydroxymethylcyclopropyl) glycine ((+)-3) is described. This novel C-3‘ substituted carboxy cyclopropyl glycine is a highly potent group 2 and group 3 m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1da05542dd760a151e9a35936f1754a
https://pubmed.ncbi.nlm.nih.gov/14711315
https://pubmed.ncbi.nlm.nih.gov/14711315
Publikováno v:
Organic letters. 4(10)
[reaction: see text] A synthesis of cryptophycin 52 is reported using a Shi epoxidation strategy to install the epoxide moiety in a diastereoselective fashion. Several epoxidation results for cryptophycin substrates are disclosed followed by a discus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::617c94b21e870a639484dd741066621f
https://pubmed.ncbi.nlm.nih.gov/12000306
https://pubmed.ncbi.nlm.nih.gov/12000306
Publikováno v:
Journal of the American Chemical Society. 112:2024-2026
The authors report the chemical preparation and some preliminary reaction chemistry of [Cp[sup *]Rh([mu]-Cl)][sub 2] (1) (Cp[sup *] = C[sub 5]Me[sub 5]), a Rh(II) dimer with a reactive Rh-Rh bond. While many Rh(II) complexes containing Rh-Rh bonds ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9c04a49d6140619094dafa2fe7a035c
https://doi.org/10.1021/ja00161a071
https://doi.org/10.1021/ja00161a071
Autor:
Stanley P. Kolis, MarvinM. Hansen, Enver Arslantas, Lukas Brändli, Jonas Buser, Amy C. DeBaillie, Andrea L. Frederick, David W. Hoard, Adrienne Hollister, Dominique Huber, Thomas Kull, Ryan J. Linder, Thomas J. Martin, Rachel N. Richey, Alfred Stutz, Michael Waibel, Jeffrey A. Ward, Alexandru Zamfir
Publikováno v:
Organic Process Research & Development; Sep2015, Vol. 19 Issue 9, p1203-1213, 11p
Autor:
Marvin M. Hansen, Daniel J. Jarmer, Enver Arslantas, Amy C. DeBaillie, AndreaL. Frederick, Molly Harding, David W. Hoard, Adrienne Hollister, Dominique Huber, Stanley P. Kolis, Jennifer E. Kuehne-Willmore, Thomas Kull, Michael E. Laurila, Ryan J. Linder, Thomas J. Martin, Joseph R. Martinelli, Michael J. McCulley, Rachel N. Richey, Derek R. Starkey, Jeffrey A. Ward
Publikováno v:
Organic Process Research & Development; Sep2015, Vol. 19 Issue 9, p1214-1230, 17p