H4 receptor antagonism exhibits anti-nociceptive effects in inflammatory and neuropathic pain models in rats

Autor: Arthur A. Hancock, Jill M. Wetter, Kennan C. Marsh, Prisca Honore, Gin C. Hsieh, Anita K. Salyers, Prasant Chandran, Timothy A. Esbenshade, Marlon D. Cowart, Joe Mikusa, Jorge D. Brioni, Erica J. Wensink, Madhavi Pai, Thomas R. Miller, Scott J. Baker, Chang Z. Zhu, David G. Witte

Publikováno v: Pharmacology Biochemistry and Behavior. 95:41-50

The histamine H(4) receptor (H(4)R) is expressed primarily on cells involved in inflammation and immune responses. To determine the potential role of H(4)R in pain transmission, the effects of JNJ7777120, a potent and selective H(4) antagonist, were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3217e8b864839ddd3ab2c66a0d548d8d
https://doi.org/10.1016/j.pbb.2009.12.004

An 80-Amino Acid Deletion in the Third Intracellular Loop of a Naturally Occurring Human Histamine H3 Isoform Confers Pharmacological Differences and Constitutive Activity

Autor: Peter van Meer, Marlon D. Cowart, Marina Strakhova, David G. Witte, John L. Baranowski, Rob Leurs, Arthur A. Hancock, Brian R. Estvander, Gerold Bongers, Thomas R. Miller, Kathleen M. Krueger, Remko A. Bakker, Timothy A. Esbenshade

Publikováno v: The Journal of Pharmacology and Experimental Therapeutics, 323(3), 888-98. American Society for Pharmacology and Experimental Therapeutics
Bongers, G M, Krueger, K M, Miller, T R, Baranowski, J L, Estvander, B R, Witte, D G, Strakhova, M I, van der Meer, P, Bakker, R A, Cowart, M D, Hancock, A A, Esbenshade, T A & Leurs, R 2007, ' An 80-amino acid deletion in the third intracellular loop of a naturally occurring human histamine H3 isoform confers pharmacological differences and constitutive activity ', The Journal of Pharmacology and Experimental Therapeutics, vol. 323, no. 3, pp. 888-98 . https://doi.org/10.1124/jpet.107.127639

In this article, we pharmacologically characterized two naturally occurring human histamine H3 receptor (hH3R) isoforms, hH3R(445) and hH3R(365). These abundantly expressed splice variants differ by a deletion of 80 amino acids in the intracellular l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::062d4248884dcb2bada0b5a82bba63e3
https://doi.org/10.1124/jpet.107.127639

Detection of multiple H3 receptor affinity states utilizing [3 H]A-349821, a novel, selective, non-imidazole histamine H3 receptor inverse agonist radioligand

Autor: Arthur A. Hancock, Bruce W. Surber, Rahul Sharma, David G. Witte, Timothy A. Esbenshade, Tracy L. Carr, Betty B. Yao, Kathleen M. Krueger, Ramin Faghih, Thomas R. Miller, Steven Cassar

Publikováno v: British Journal of Pharmacology. 148:657-670

A-349821 is a selective histamine H3 receptor antagonist/inverse agonist. Herein, binding of the novel non-imidazole H3 receptor radioligand [3H]A-349821 to membranes expressing native or recombinant H3 receptors from rat or human sources was charact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3722fc65f7795de1c444ddfd44a24b85
https://doi.org/10.1038/sj.bjp.0706752

Structure–activity relationships of non-imidazole H3 receptor ligands. Part 3: 5-Substituted 3-phenyl-1,2,4-oxadiazoles as potent antagonists

Autor: Betty B. Yao, Ramin Faghih, Thomas R. Miller, Henry Zhang, Youssef L. Bennani, Timothy A. Esbenshade, David G. Witte, Gregory A. Gfesser, Gerard B. Fox, Jia Bao Pan, Arthur A. Hancock, Chae-Hee Kang, Jürgen Dinges, Kathy M. Krueger

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 14:673-676

Further SAR studies on novel histamine H(3) receptor antagonists are presented. Compound 14bb is a potent antagonist of both the rat cortical and human clone receptors, and is demonstrated to act functionally as an antagonist in an in vivo mouse dips

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fed226c898efdb95d448246274d9c2d1
https://doi.org/10.1016/j.bmcl.2003.11.038

Cerebrospinal fluid cytokine dynamics differ between Alzheimer disease patients and elderly controls

Autor: Robert A. Lenz, Teresa Ellis, Viswanath Devanarayan, David G. Witte, Jeffrey F. Waring, Daniel A. Llano, Jinhe Li

Publikováno v: Alzheimer disease and associated disorders. 26(4)

The time courses of levels of multiple plasma and cerebrospinal fluid (CSF) cytokines in patients with Alzheimer disease (AD) and in age-matched control subjects were compared. Interleukin (IL)-1β, IL-2, IL-6, IL-8, IL-10, IL-12p70, granulocyte-macr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee7c37e6c662efd5c6270a2e5d5199b0
https://pubmed.ncbi.nlm.nih.gov/22089638