Zobrazeno 1 - 10
of 106
pro vyhledávání: '"David Casero"'
Autor:
Gunjan Sharma, Tiffany M. Tran, Ishu Bansal, Mohammad Sabique Beg, Ruchi Bhardwaj, Jaspal Bassi, Yuande Tan, Amit Kumar Jaiswal, Christine Tso, Ayushi Jain, Jay Singh, Parthaprasad Chattopadhyay, Archna Singh, Anita Chopra, Sameer Bakhshi, David Casero, Dinesh S. Rao, Jayanth Kumar Palanichamy
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-20 (2023)
Abstract Background Acute lymphoblastic leukemia (ALL) is the most common pediatric hematological malignancy, with ETV6::RUNX1 being the most prevalent translocation whose exact pathogenesis remains unclear. IGF2BP1 (Insulin-like Growth Factor 2 Bind
Externí odkaz:
https://doaj.org/article/a125d7d6927e459099c0c52bba351a83
Autor:
Suwen Li, Chloe S. Wang, Amélie Montel-Hagen, Ho-Chung Chen, Shawn Lopez, Olivia Zhou, Kristy Dai, Steven Tsai, William Satyadi, Carlos Botero, Claudia Wong, David Casero, Gay M. Crooks, Christopher S. Seet
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112241- (2023)
Summary: Generation of chimeric antigen receptor (CAR) T cells from pluripotent stem cells (PSCs) will enable advances in cancer immunotherapy. Understanding how CARs affect T cell differentiation from PSCs is important for this effort. The recently
Externí odkaz:
https://doaj.org/article/4cdfe5ceca0243298f94c0b20a002a90
Autor:
Jennifer K. King, Tiffany M. Tran, May H. Paing, Yuxin Yin, Amit K. Jaiswal, Ching-Hsuan Tso, Koushik Roy, David Casero, Dinesh S. Rao
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The microRNA, miR-146a, is a negative feedback regulator of the central immune transcription factor, nuclear factor kappa B (NFkB). MiR-146a plays important roles in the immune system, and miR-146a deficient mice show a complex phenotype with feature
Externí odkaz:
https://doaj.org/article/8468360204dd49d587b8c732d010f92e
Autor:
Amit Kumar Jaiswal, Hellen Truong, Tiffany M. Tran, Tasha L. Lin, David Casero, Michael O. Alberti, Dinesh S. Rao
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Post-transcriptional gene regulation, including that by RNA binding proteins (RBPs), has recently been described as an important mechanism in cancer. We had previously identified a set of RBPs that were highly dysregulated in B-cell acute ly
Externí odkaz:
https://doaj.org/article/21414bf1581e42608d925e918106ab1e
Autor:
Fernanda Rosa, Ashok K. Sharma, Manoj Gurung, David Casero, Katelin Matazel, Lars Bode, Christy Simecka, Ahmed A. Elolimy, Patricia Tripp, Christopher Randolph, Timothy W. Hand, Keith D. Williams, Tanya LeRoith, Laxmi Yeruva
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Human milk harbors complex carbohydrates, including human milk oligosaccharides (HMOs), the third most abundant component after lactose and lipids. HMOs have been shown to impact intestinal microbiota, modulate the intestinal immune response, and pre
Externí odkaz:
https://doaj.org/article/1e5f16af75cc4b0dbbc706a7717eb34f
Autor:
Victoria Sun, Mark Sharpley, Karolina E. Kaczor-Urbanowicz, Patrick Chang, Amélie Montel-Hagen, Shawn Lopez, Alexandre Zampieri, Yuhua Zhu, Stéphanie C. de Barros, Chintan Parekh, David Casero, Utpal Banerjee, Gay M. Crooks
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Although metabolic pathways have been shown to control differentiation and activation in peripheral T cells, metabolic studies on thymic T cell development are still lacking, especially in human tissue. In this study, we use transcriptomics and extra
Externí odkaz:
https://doaj.org/article/8f2b8318fd3644e38f63610ce581b773
Autor:
Encarnacion Montecino-Rodriguez, Ying Kong, David Casero, Adrien Rouault, Kenneth Dorshkind, Peter D. Pioli
Publikováno v:
Stem Cell Reports, Vol 12, Iss 3, Pp 584-596 (2019)
Summary: Current models propose that reductions in the number of lymphoid-biased hematopoietic stem cells (Ly-HSCs) underlie age-related declines in lymphopoiesis. We show that Ly-HSCs do not decline in number with age. Old Ly-HSCs exhibit changes in
Externí odkaz:
https://doaj.org/article/5799bc5d0a354555b14bd2c47fd3e4cc
Autor:
Chee Jia Chin, Suwen Li, Mirko Corselli, David Casero, Yuhua Zhu, Chong Bin He, Reef Hardy, Bruno Péault, Gay M. Crooks
Publikováno v:
Stem Cell Reports, Vol 10, Iss 2, Pp 436-446 (2018)
Summary: Various mesenchymal cell types have been identified as critical components of the hematopoietic stem/progenitor cell (HSPC) niche. Although several groups have described the generation of mesenchyme from human pluripotent stem cells (hPSCs),
Externí odkaz:
https://doaj.org/article/ef2e4bbc77a14fbd97b01cc105b97f69
Autor:
David Casero, Kirandeep Gill, Vijayalakshmi Sridharan, Igor Koturbash, Gregory Nelson, Martin Hauer-Jensen, Marjan Boerma, Jonathan Braun, Amrita K. Cheema
Publikováno v:
Microbiome, Vol 5, Iss 1, Pp 1-18 (2017)
Abstract Background Space travel is associated with continuous low dose rate exposure to high linear energy transfer (LET) radiation. Pathophysiological manifestations after low dose radiation exposure are strongly influenced by non-cytocidal radiati
Externí odkaz:
https://doaj.org/article/cb615717b6f34ad6ac2b1fa76bbb750f
Autor:
Thilini R. Fernando, Jorge R. Contreras, Matteo Zampini, Norma I. Rodriguez-Malave, Michael O. Alberti, Jaime Anguiano, Tiffany M. Tran, Jayanth K. Palanichamy, Jasmine Gajeton, Nolan M. Ung, Cody J. Aros, Ella V. Waters, David Casero, Giuseppe Basso, Martina Pigazzi, Dinesh S. Rao
Publikováno v:
Molecular Cancer, Vol 16, Iss 1, Pp 1-15 (2017)
Abstract Background Long non-coding RNAs (lncRNAs) play a variety of cellular roles, including regulation of transcription and translation, leading to alterations in gene expression. Some lncRNAs modulate the expression of chromosomally adjacent gene
Externí odkaz:
https://doaj.org/article/84859c98636e4cc29384ab130c2ebf71