Zobrazeno 1 - 10
of 164
pro vyhledávání: '"David Alsteens"'
Autor:
Ankita Ray, Thu Thi Minh Tran, Rita dos Santos Natividade, Rodrigo A. Moreira, Joshua D. Simpson, Danahe Mohammed, Melanie Koehler, Simon J. L Petitjean, Qingrong Zhang, Fabrice Bureau, Laurent Gillet, Adolfo B. Poma, David Alsteens
Publikováno v:
ACS Nanoscience Au, Vol 4, Iss 2, Pp 136-145 (2024)
Externí odkaz:
https://doaj.org/article/f73a43eb6f2141ff8a56890bcd533545
Autor:
Pengcheng Shang, Joshua D. Simpson, Gwen M. Taylor, Danica M. Sutherland, Olivia L. Welsh, Pavithra Aravamudhan, Rita Dos Santos Natividade, Kristina Schwab, Joshua J. Michel, Amanda C. Poholek, Yijen Wu, Dhivyaa Rajasundaram, Melanie Koehler, David Alsteens, Terence S. Dermody
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Mammalian orthoreovirus (reovirus) infects most mammals and is associated with celiac disease in humans. In mice, reovirus infects the intestine and disseminates systemically to cause serotype-specific patterns of disease in the brain. To id
Externí odkaz:
https://doaj.org/article/3daf5306cc154b38afd87eb89709065d
Autor:
Amaury Stommen, Marine Ghodsi, Anne-Sophie Cloos, Louise Conrard, Andra C. Dumitru, Patrick Henriet, Christophe E. Pierreux, David Alsteens, Donatienne Tyteca
Publikováno v:
Biomolecules, Vol 14, Iss 1, p 51 (2023)
Piezo1 is a mechanosensitive ion channel required for various biological processes, but its regulation remains poorly understood. Here, we used erythrocytes to address this question since they display Piezo1 clusters, a strong and dynamic cytoskeleto
Externí odkaz:
https://doaj.org/article/6f6df9e4557547c3bcc459ac8a573a93
Autor:
Simon J. L. Petitjean, Wenzhang Chen, Melanie Koehler, Ravikumar Jimmidi, Jinsung Yang, Danahe Mohammed, Blinera Juniku, Megan L. Stanifer, Steeve Boulant, Stéphane P. Vincent, David Alsteens
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Cell surface attachment factors, such as glycans, play an important role in viral infection. Here, Petitjean et al. show that SARS-CoV-2 specifically binds to 9-Oacetylated sialic acid and have designed novel inhibitors based on multivalent derivativ
Externí odkaz:
https://doaj.org/article/ba3cf805c0e646fda33f22eb5939f940
Autor:
Melanie Koehler, Ankita Ray, Rodrigo A. Moreira, Blinera Juniku, Adolfo B. Poma, David Alsteens
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Here, the authors combine single-molecule atomic force spectroscopy measurements and molecular dynamics simulations to investigate the binding of spike proteins from four SARS-CoV-2 variants of concern (VoC) to the human ACE2 receptor. They observe a
Externí odkaz:
https://doaj.org/article/8d29b638bc874af1a0b0f812091804bf
Autor:
Laura Glorieux, Laura Vandooren, Sylvie Derclaye, Sébastien Pyr dit Ruys, Paloma Oncina-Gil, Anna Salowka, Gaëtan Herinckx, Elias Aajja, Pascale Lemoine, Catherine Spourquet, Hélène Lefort, Patrick Henriet, Donatienne Tyteca, Francesca M. Spagnoli, David Alsteens, Didier Vertommen, Christophe E. Pierreux
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 12, p 10268 (2023)
The pancreas is a complex organ consisting of differentiated cells and extracellular matrix (ECM) organized adequately to enable its endocrine and exocrine functions. Although much is known about the intrinsic factors that control pancreas developmen
Externí odkaz:
https://doaj.org/article/d382c5adc80b4bd09962e1eff532acb7
Autor:
Melanie Koehler, Simon J. L. Petitjean, Jinsung Yang, Pavithra Aravamudhan, Xayathed Somoulay, Cristina Lo Giudice, Mégane A. Poncin, Andra C. Dumitru, Terence S. Dermody, David Alsteens
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Reovirus endocytosis depends on junctional adhesion molecule A (JAM-A) and β1 integrin binding. Here, Koehler et al. use single-virus force spectroscopy and confocal microscopy to demonstrate a direct interaction between reovirus and β1 integrins v
Externí odkaz:
https://doaj.org/article/3a1ab7363b9f44ae9cb1014c0cfba8dc
Autor:
Andra C. Dumitru, R. N. V. Krishna Deepak, Heng Liu, Melanie Koehler, Cheng Zhang, Hao Fan, David Alsteens
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-13 (2020)
Dumitru et al. probe the ligand-binding mechanism and activation of the human G protein-coupled C5a receptor (C5aR) and discover a cooperativity between the two orthosteric binding sites. Their findings, probing the dynamic aspects of receptor–liga
Externí odkaz:
https://doaj.org/article/443aebd51a024799afe9304b404255fe
Autor:
Marion Mathelié-Guinlet, Felipe Viela, Giampiero Pietrocola, Pietro Speziale, David Alsteens, Yves F. Dufrêne
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
During colonization of host tissues and biomaterials, staphylococci are exposed to extreme mechanical forces. Here authors use force-clamp spectroscopy and show that the dock, lock and latch interaction between staphylococcal surface protein SpsD and
Externí odkaz:
https://doaj.org/article/feca3bc0c89c4e12a02e7b8246148655
Autor:
Jinsung Yang, Simon J. L. Petitjean, Melanie Koehler, Qingrong Zhang, Andra C. Dumitru, Wenzhang Chen, Sylvie Derclaye, Stéphane P. Vincent, Patrice Soumillion, David Alsteens
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
SARS-CoV-2 spike protein binds host ACE2 for virus entry. Here, the authors determine kinetic and thermodynamic properties of this interaction using atomic force microscopy, develop peptides that inhibit binding and suggest existence of additional at
Externí odkaz:
https://doaj.org/article/22063247702e4aba8bea199d3422791c