Zobrazeno 1 - 10
of 430
pro vyhledávání: '"David A. Hay"'
Autor:
Eduardo H. Gilglioni, Ao Li, Wadsen St-Pierre-Wijckmans, Tzu-Keng Shen, Israel Pérez-Chávez, Garnik Hovhannisyan, Michela Lisjak, Javier Negueruela, Valerie Vandenbempt, Julia Bauzá-Martinez, Jose M. Herranz, Daria Ezeriņa, Stéphane Demine, Zheng Feng, Thibaut Vignane, Lukas Otero Sanchez, Flavia Lambertucci, Alena Prašnická, Jacques Devière, David C. Hay, Jose A. Encinar, Sumeet Pal Singh, Joris Messens, Milos R. Filipovic, Hayley J. Sharpe, Eric Trépo, Wei Wu, Esteban N. Gurzov
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract Fat accumulation, de novo lipogenesis, and glycolysis are key drivers of hepatocyte reprogramming and the consequent metabolic dysfunction-associated steatotic liver disease (MASLD). Here we report that obesity leads to dysregulated expressi
Externí odkaz:
https://doaj.org/article/47d15d12bd9c4154ade149ceeddbddb9
Autor:
David C. Hay
Publikováno v:
Heliyon, Vol 10, Iss 9, Pp e30396- (2024)
Externí odkaz:
https://doaj.org/article/e003d894591640de8e7ba3b5422997d9
Publikováno v:
Biosensors, Vol 14, Iss 9, p 425 (2024)
Traditional drug development is a long and expensive process with high rates of failure. This has prompted the pharmaceutical industry to seek more efficient drug development frameworks, driving the emergence of organ-on-a-chip (OOC) based on microfl
Externí odkaz:
https://doaj.org/article/75cec231f84a4df882a469a0e36ad3f4
Publikováno v:
Cells, Vol 13, Iss 18, p 1594 (2024)
To accurately study human organ function and disease ‘in the dish’, it is necessary to develop reliable cell-based models that closely track human physiology. Our interest lay with the liver, which is the largest solid organ in the body. The live
Externí odkaz:
https://doaj.org/article/0462fd83545e40cb9ad3d4ac00b00098
Publikováno v:
Cells, Vol 12, Iss 12, p 1604 (2023)
The liver performs a multitude of bodily functions, whilst retaining the ability to regenerate damaged tissue. In this review, we discuss sex steroid biology, regulation of mammalian liver physiology and the development of new model systems to improv
Externí odkaz:
https://doaj.org/article/71480124054547bf98b11a651933734b
Autor:
Sohinee Bhattacharya, Edwin Amalraj Raja, David C Hay, Rod Thomas Mitchell, Aikaterini Zafeiri, Paul A Fowler
Publikováno v:
BMJ Open, Vol 12, Iss 5 (2022)
Objectives To identify any associations between in utero exposure to five over-the-counter (non-prescription) analgesics (paracetamol, ibuprofen, aspirin, diclofenac, naproxen) and adverse neonatal outcomes.Design Retrospective cohort study using the
Externí odkaz:
https://doaj.org/article/1b635d995f49455dbbcc9efa361a1ba6
Autor:
Yu Wang, Michael H. Tatham, Wolfgang Schmidt-Heck, Carolyn Swann, Karamjit Singh-Dolt, Jose Meseguer-Ripolles, Baltasar Lucendo-Villarin, Tilo Kunath, Timothy R. Rudd, Andrew J.H. Smith, Jan G. Hengstler, Patricio Godoy, Ronald T. Hay, David C. Hay
Publikováno v:
iScience, Vol 16, Iss , Pp 206-217 (2019)
Summary: During mammalian development, liver differentiation is driven by signals that converge on multiple transcription factor networks. The hepatocyte nuclear factor signaling network is known to be essential for hepatocyte specification and maint
Externí odkaz:
https://doaj.org/article/4a91a3c282f3471bad0373765ad436f8
Autor:
Matthew C. Sinton, Jose Meseguer-Ripolles, Baltasar Lucendo-Villarin, Amanda J. Drake, David C. Hay
Publikováno v:
STAR Protocols, Vol 2, Iss 2, Pp 100493- (2021)
Summary: This protocol describes the production of hepatocyte-like cells (HLCs) from human pluripotent stem cells and how to induce hepatic steatosis, a condition characterized by intracellular lipid accumulation. Following differentiation to an HLC
Externí odkaz:
https://doaj.org/article/8d13b0dc3bd7402bb841e0635d89763b
Publikováno v:
STAR Protocols, Vol 2, Iss 2, Pp 100502- (2021)
Summary: This protocol describes how to produce human liver spheres from pluripotent stem cell-derived hepatic progenitors, endothelial cells, and hepatic stellate cells. Liver spheres form by self-assembly in microwells, generating up to 73 spheres
Externí odkaz:
https://doaj.org/article/c545e9cb181540ee87b21a9245f16b38
Autor:
Jose Meseguer-Ripolles, Baltasar Lucendo-Villarin, Carl Tucker, Sofia Ferreira-Gonzalez, Natalie Homer, Yu Wang, Philip J. Starkey Lewis, Enrique M Toledo, Esther Mellado-Gomez, Joanna Simpson, Oliver Flint, Himjyot Jaiswal, Nicola L. Beer, Allan E. Karlsen, Stuart J. Forbes, James W. Dear, Jeremy Hughes, David C. Hay
Publikováno v:
iScience, Vol 24, Iss 6, Pp 102552- (2021)
Summary: Liver disease is a major cause of premature death. Oxidative stress in the liver represents a key disease driver. Compounds, such as dimethyl fumarate (DMF), can activate the antioxidant response and are used clinically to treat disease. In
Externí odkaz:
https://doaj.org/article/0fd0f2e5fb724e438758d7df1a29d1bc