Zobrazeno 1 - 10
of 296
pro vyhledávání: '"David A. Boothman"'
Autor:
Xiaoguang Li, Zhida Liu, Anli Zhang, Chuanhui Han, Aijun Shen, Lingxiang Jiang, David A. Boothman, Jian Qiao, Yang Wang, Xiumei Huang, Yang-Xin Fu
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Improper innate sensing within the tumor microenvironment limits immunotherapy success. Here, the authors show that targeting NQO1 triggers immunogenic innate sensing to reactivate T cells and overcome immune checkpoint blockade resistance.
Externí odkaz:
https://doaj.org/article/f18e4e20985045188e6e4ba9bb61cc6d
Autor:
Mario C. Chang, Rohit Mahar, Marc A. McLeod, Anthony G. Giacalone, Xiumei Huang, David A. Boothman, Matthew E. Merritt
Publikováno v:
Nutrients, Vol 14, Iss 15, p 3020 (2022)
The compound β-lapachone, a naturally derived naphthoquinone, has been utilized as a potent medicinal nutrient to improve health. Over the last twelve years, numerous reports have demonstrated distinct associations of β-lapachone and NAD(P)H: quino
Externí odkaz:
https://doaj.org/article/29b1ea1f65ac47e59e40de7f8fb70257
Autor:
Kirtikar Shukla, Naveen Singh, Joshua E. Lewis, Allen W. Tsang, David A. Boothman, Melissa L. Kemp, Cristina M. Furdui
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Head and Neck Squamous Cell Cancer (HNSCC) presents with multiple treatment challenges limiting overall survival rates and affecting patients' quality of life. Amongst these, resistance to radiation therapy constitutes a major clinical problem in HNS
Externí odkaz:
https://doaj.org/article/4ca9878287434b678ddc673d4411d432
Autor:
Colton L. Starcher, S. Louise Pay, Naveen Singh, I-Ju Yeh, Snehal B. Bhandare, Xiaolin Su, Xiumei Huang, Erik A. Bey, Edward A. Motea, David A. Boothman
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Ionizing radiation (IR) creates lethal DNA damage that can effectively kill tumor cells. However, the high dose required for a therapeutic outcome also damages healthy tissue. Thus, a therapeutic strategy with predictive biomarkers to enhance the ben
Externí odkaz:
https://doaj.org/article/a9f93e68362c453783961f81542a9d68
Autor:
Laura Torrente, Nicolas Prieto-Farigua, Aimee Falzone, Cody M. Elkins, David A. Boothman, Eric B. Haura, Gina M. DeNicola
Publikováno v:
Redox Biology, Vol 30, Iss , Pp - (2020)
Alterations in the NRF2/KEAP1 pathway result in the constitutive activation of NRF2, leading to the aberrant induction of antioxidant and detoxification enzymes, including NQO1. The NQO1 bioactivatable agent β-lapachone can target cells with high NQ
Externí odkaz:
https://doaj.org/article/3446e25af99d44cc912f443dfda518a7
Autor:
Darren R. Carpizo, S. David Kimball, Stewart N. Loh, David A. Boothman, John Gilleran, Alan J. Blayney, Bing Na, Tracy Withers, Yue Liu, Adam R. Blanden, Anthony F. Bencivenga, Xin Yu, Saif Zaman
Supplementary tables to show combination index values for combination treatments of indicated compounds. Supplementary Table 1. Combination Index values for initial combination treatment of ZMC1 with chemotherapy drugs; Supplementary Table 2. Combina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b552ac3dcc2e7479c6659a9b74c1df4
https://doi.org/10.1158/1535-7163.22505851.v1
https://doi.org/10.1158/1535-7163.22505851.v1
The fundamental role that NAD(P)H/quinone oxidoreductase 1 (NQO1) plays, in normal cells, as a cytoprotective enzyme guarding against stress induced by reactive oxygen species (ROS) is well documented. However, what is not known is whether the observ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a137e4908bff155147d7cad613e9312
https://doi.org/10.1158/1541-7786.c.6540030.v1
https://doi.org/10.1158/1541-7786.c.6540030.v1
Autor:
Darren R. Carpizo, S. David Kimball, Stewart N. Loh, David A. Boothman, John Gilleran, Alan J. Blayney, Bing Na, Tracy Withers, Yue Liu, Adam R. Blanden, Anthony F. Bencivenga, Xin Yu, Saif Zaman
Suppl. Fig. S1 display ZMC1 structure. Suppl. Fig. S2 showed no synergy in combination treatment of ZMC1 and Adriamycin or IR. Suppl. Fig. S3 showed synergy in Detroit 562 cells by combination treatment of ZMC1 and Irinotecan in the presence of GSH.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::373924276ceb44d0f28384c120bb1228
https://doi.org/10.1158/1535-7163.22505854
https://doi.org/10.1158/1535-7163.22505854
Autor:
David A. Boothman, Jinming Gao, Douglas R. Spitz, Donald J. Buchsbaum, William G. Bornmann, David M. Euhus, Cheryl Lewis, Michael Boatman, Amy Rommel, Zachary Moore, Lifen Cao, Malina Patel, Long Shan Li, John J. Pink, Vernon E. Anderson, Marie Varnes, Melissa C. Srougi, Kathryn E. Reinicke, Erik A. Bey
PDF file, 1661K, Supplemental Figure S1- Chemical Structures. Supplemental Figure S2-Oxygen Consumption in MCF-7 Cells treated with or without betalapchone and dicoumarol. Supplemental Figure S2 legend. Supplemental Figure S3-Survival assay for norma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b0292db08a0f90fe3921f701ed3216c
https://doi.org/10.1158/1535-7163.22498413.v1
https://doi.org/10.1158/1535-7163.22498413.v1
Autor:
Darren R. Carpizo, S. David Kimball, Stewart N. Loh, David A. Boothman, John Gilleran, Alan J. Blayney, Bing Na, Tracy Withers, Yue Liu, Adam R. Blanden, Anthony F. Bencivenga, Xin Yu, Saif Zaman
Suppl. Methods included the methods used in the paper, Cell growth inhibition assay, Immunofluorescent staining, Synthesis of ZMC1, Synthesis of 2,2'-((2-Ethoxy-2-oxoethyl)azanediyl)diacetic acid (NTA-MEE) and NTA-DEE, Zn2+-Kd measurements by competi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7118ac2756632efdd25988ccd02b669d
https://doi.org/10.1158/1535-7163.22505848.v1
https://doi.org/10.1158/1535-7163.22505848.v1