Zobrazeno 1 - 10
of 135
pro vyhledávání: '"David I. Roper"'
Autor:
Rie Nygaard, Chris L. B. Graham, Meagan Belcher Dufrisne, Jonathan D. Colburn, Joseph Pepe, Molly A. Hydorn, Silvia Corradi, Chelsea M. Brown, Khuram U. Ashraf, Owen N. Vickery, Nicholas S. Briggs, John J. Deering, Brian Kloss, Bruno Botta, Oliver B. Clarke, Linda Columbus, Jonathan Dworkin, Phillip J. Stansfeld, David I. Roper, Filippo Mancia
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Peptidoglycan (PG) is an essential structural component of the bacterial cell wall that is synthetized during cell division and elongation. PG forms an extracellular polymer crucial for cellular viability, the synthesis of which is the targe
Externí odkaz:
https://doaj.org/article/f8db36713a734cacbd61374a4c829bb4
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Escherichia coli is one of the most common Gram-negative pathogens and is responsible for infection leading to neonatal meningitis and sepsis. The FtsZ protein is a bacterial tubulin homolog required for cell division in most species, including E. co
Externí odkaz:
https://doaj.org/article/d50f413b61ea443ba63c2e9a739ea6bd
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
Cell division in Streptococcus pneumoniae (pneumococcus) is performed and regulated by a protein complex consisting of at least 14 different protein elements; known as the divisome. Recent findings have advanced our understanding of the molecular eve
Externí odkaz:
https://doaj.org/article/aa9cf159fe594dcfaff19289c9b01a27
Autor:
Jack Alfred Bryant, Faye C Morris, Timothy J Knowles, Riyaz Maderbocus, Eva Heinz, Gabriela Boelter, Dema Alodaini, Adam Colyer, Peter J Wotherspoon, Kara A Staunton, Mark Jeeves, Douglas F Browning, Yanina R Sevastsyanovich, Timothy J Wells, Amanda E Rossiter, Vassiliy N Bavro, Pooja Sridhar, Douglas G Ward, Zhi-Soon Chong, Emily CA Goodall, Christopher Icke, Alvin CK Teo, Shu-Sin Chng, David I Roper, Trevor Lithgow, Adam F Cunningham, Manuel Banzhaf, Michael Overduin, Ian R Henderson
Publikováno v:
eLife, Vol 9 (2020)
The Gram-negative outer-membrane envelops the bacterium and functions as a permeability barrier against antibiotics, detergents, and environmental stresses. Some virulence factors serve to maintain the integrity of the outer membrane, including DolP
Externí odkaz:
https://doaj.org/article/f638738df7ef4c79a9be99c12141984c
Autor:
Avinash S. Punekar, Firdaus Samsudin, Adrian J. Lloyd, Christopher G. Dowson, David J. Scott, Syma Khalid, David I. Roper
Publikováno v:
The Cell Surface, Vol 2, Iss , Pp 54-66 (2018)
Bacterial peptidoglycan glycosyltransferases (PGT) catalyse the essential polymerization of lipid II into linear glycan chains required for peptidoglycan biosynthesis. The PGT domain is composed of a large head subdomain and a smaller jaw subdomain a
Externí odkaz:
https://doaj.org/article/31c890c7d74f40edb5f000c832d21b84
Autor:
Sarah Batson, Cesira de Chiara, Vita Majce, Adrian J. Lloyd, Stanislav Gobec, Dean Rea, Vilmos Fülöp, Christopher W. Thoroughgood, Katie J. Simmons, Christopher G. Dowson, Colin W. G. Fishwick, Luiz Pedro S. de Carvalho, David I. Roper
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-7 (2017)
The antibiotic D-cycloserine (DCS) targets the peptidoglycan biosynthesis enzyme D-Ala-D-Ala ligase (Ddl). Here the authors reveal the DCS inhibitory mechanism by determining the structure of E. coli DdlB with a phosphorylated DCS molecule in the act
Externí odkaz:
https://doaj.org/article/66e59bce52674d29b83d6b33b62cc099
Autor:
Anh T. Tran, Emma E. Watson, Venugopal Pujari, Trent Conroy, Luke J. Dowman, Andrew M. Giltrap, Angel Pang, Weng Ruh Wong, Roger G. Linington, Sebabrata Mahapatra, Jessica Saunders, Susan A. Charman, Nicholas P. West, Timothy D. H. Bugg, Julie Tod, Christopher G. Dowson, David I. Roper, Dean C. Crick, Warwick J. Britton, Richard J. Payne
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Drug resistant tuberculosis (TB) infections are emerging at a high rate, with only few therapeutic options currently available. Here, the authors report synthetic analogues of the natural product sansanmycin that target mycobacterial cell wall biosyn
Externí odkaz:
https://doaj.org/article/fa20939585404c08a152992a15e9084c
Autor:
Carmina Micelli, Yunfei Dai, Nicole Raustad, Ralph R. Isberg, Christopher G. Dowson, Adrian J. Lloyd, Edward Geisinger, Allister Crow, David I. Roper
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Acinetobacter baumannii is a gram-negative bacterial pathogen that causes challenging nosocomial infections. β-lactam targeting of penicillin-binding protein (PBP)–mediated cell wall peptidoglycan (PG) formation is a well-established antimicrobial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78aa49b272092f84dd69815b9c4dcce0
https://doi.org/10.1073/pnas.2215237120
https://doi.org/10.1073/pnas.2215237120
Autor:
Elinor Hortle, David I. Roper, Warwick J. Britton, Richard J. Payne, Gregory M. Cook, Wendy Tran, Paige M. E. Hawkins, Alexander Stoye, Christopher G. Dowson, Rebecca E Audette, Thomas Balle, Jessica L. Ochoa, Gayathri Nagalingam, Daniel J Ford, Ali Saad Kusay, Venugopal Pujari, Roger G. Linington, Chen-Yi Cheung, Dean C. Crick, Eric J. Rubin, Stefan H. Oehlers, Susan A. Charman
Publikováno v:
Journal of Medicinal Chemistry. 64:17326-17345
Herein, we report the design and synthesis of inhibitors of Mycobacterium tuberculosis (Mtb) phospho-MurNAc-pentapeptide translocase I (MurX), the first membrane-associated step of peptidoglycan synthesis, leveraging the privileged structure of the s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e08cda86f6791396aa219a030366f02
https://doi.org/10.1021/acs.jmedchem.1c01407
https://doi.org/10.1021/acs.jmedchem.1c01407
Autor:
Alvin C. K. Teo, David I. Roper
Publikováno v:
Antibiotics, Vol 4, Iss 4, Pp 495-520 (2015)
We are entering an era where the efficacy of current antibiotics is declining, due to the development and widespread dispersion of antibiotic resistance mechanisms. These factors highlight the need for novel antimicrobial discovery. A large number of
Externí odkaz:
https://doaj.org/article/e026b66c4981431391b230448c5c7109