Zobrazeno 1 - 10
of 72
pro vyhledávání: '"David, van Dijk"'
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-17 (2023)
Abstract Many deep learning-based methods have been proposed to handle complex single-cell data. Deep learning approaches may also prove useful to jointly analyze single-cell RNA sequencing (scRNA-seq) and single-cell T cell receptor sequencing (scTC
Externí odkaz:
https://doaj.org/article/cc49e7a6731d4fb8b1659da3f467e6bc
A machine learning method for the identification and characterization of novel COVID-19 drug targets
Autor:
Bruce Schultz, Lauren Nicole DeLong, Aliaksandr Masny, Manuel Lentzen, Tamara Raschka, David van Dijk, Andrea Zaliani, COPERIMOplus, Holger Fröhlich
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract In addition to vaccines, the World Health Organization sees novel medications as an urgent matter to fight the ongoing COVID-19 pandemic. One possible strategy is to identify target proteins, for which a perturbation by an existing compound
Externí odkaz:
https://doaj.org/article/13e8174ab3c44190ada785608bb33bf2
Autor:
Avraham Unterman, Tomokazu S. Sumida, Nima Nouri, Xiting Yan, Amy Y. Zhao, Victor Gasque, Jonas C. Schupp, Hiromitsu Asashima, Yunqing Liu, Carlos Cosme, Wenxuan Deng, Ming Chen, Micha Sam Brickman Raredon, Kenneth B. Hoehn, Guilin Wang, Zuoheng Wang, Giuseppe DeIuliis, Neal G. Ravindra, Ningshan Li, Christopher Castaldi, Patrick Wong, John Fournier, Santos Bermejo, Lokesh Sharma, Arnau Casanovas-Massana, Chantal B. F. Vogels, Anne L. Wyllie, Nathan D. Grubaugh, Anthony Melillo, Hailong Meng, Yan Stein, Maksym Minasyan, Subhasis Mohanty, William E. Ruff, Inessa Cohen, Khadir Raddassi, The Yale IMPACT Research Team, Laura E. Niklason, Albert I. Ko, Ruth R. Montgomery, Shelli F. Farhadian, Akiko Iwasaki, Albert C. Shaw, David van Dijk, Hongyu Zhao, Steven H. Kleinstein, David A. Hafler, Naftali Kaminski, Charles S. Dela Cruz
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-23 (2022)
SARS-CoV-2 infection can lead to progressive pathology in patients with COVID-19, but information for this disease progression is sparse. Here the authors use multi-omics approach to profile the immune responses of patients, assessing immune repertoi
Externí odkaz:
https://doaj.org/article/071dfec07b41418ab54ed9c36dc0d83e
Autor:
Bruce Schultz, Andrea Zaliani, Christian Ebeling, Jeanette Reinshagen, Denisa Bojkova, Vanessa Lage-Rupprecht, Reagon Karki, Sören Lukassen, Yojana Gadiya, Neal G. Ravindra, Sayoni Das, Shounak Baksi, Daniel Domingo-Fernández, Manuel Lentzen, Mark Strivens, Tamara Raschka, Jindrich Cinatl, Lauren Nicole DeLong, Phil Gribbon, Gerd Geisslinger, Sandra Ciesek, David van Dijk, Steve Gardner, Alpha Tom Kodamullil, Holger Fröhlich, Manuel Peitsch, Marc Jacobs, Julia Hoeng, Roland Eils, Carsten Claussen, Martin Hofmann-Apitius
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract The SARS-CoV-2 pandemic has challenged researchers at a global scale. The scientific community’s massive response has resulted in a flood of experiments, analyses, hypotheses, and publications, especially in the field of drug repurposing.
Externí odkaz:
https://doaj.org/article/18b0a7d14b824058a3306b2a9990465c
Autor:
Lingjuan Hong, Na Li, Victor Gasque, Sameet Mehta, Lupeng Ye, Yinyu Wu, Jinyu Li, Andreas Gewies, Jürgen Ruland, Karen K. Hirschi, Anne Eichmann, Caroline Hendry, David van Dijk, Arya Mani
Publikováno v:
JCI Insight, Vol 7, Iss 4 (2022)
The molecular mechanisms that drive the acquisition of distinct neural crest cell (NCC) fates is still poorly understood. Here, we identified Prdm6 as an epigenetic modifier that temporally and spatially regulates the expression of NCC specifiers and
Externí odkaz:
https://doaj.org/article/13622ad7e262445ba1054a5a926794ae
Autor:
Matthew Amodio, Dennis Shung, Daniel B. Burkhardt, Patrick Wong, Michael Simonov, Yu Yamamoto, David van Dijk, Francis Perry Wilson, Akiko Iwasaki, Smita Krishnaswamy
Publikováno v:
Patterns, Vol 2, Iss 7, Pp 100288- (2021)
Summary: Often when biological entities are measured in multiple ways, there are distinct categories of information: some information is easy-to-obtain information (EI) and can be gathered on virtually every subject of interest, while other informati
Externí odkaz:
https://doaj.org/article/e0eead5ed2a3472898bb3458cbcb81bf
Autor:
Neal G Ravindra, Mia Madel Alfajaro, Victor Gasque, Nicholas C Huston, Han Wan, Klara Szigeti-Buck, Yuki Yasumoto, Allison M Greaney, Victoria Habet, Ryan D Chow, Jennifer S Chen, Jin Wei, Renata B Filler, Bao Wang, Guilin Wang, Laura E Niklason, Ruth R Montgomery, Stephanie C Eisenbarth, Sidi Chen, Adam Williams, Akiko Iwasaki, Tamas L Horvath, Ellen F Foxman, Richard W Pierce, Anna Marie Pyle, David van Dijk, Craig B Wilen
Publikováno v:
PLoS Biology, Vol 19, Iss 3, p e3001143 (2021)
There are currently limited Food and Drug Administration (FDA)-approved drugs and vaccines for the treatment or prevention of Coronavirus Disease 2019 (COVID-19). Enhanced understanding of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
Externí odkaz:
https://doaj.org/article/953d8b25aa2b462bb1a23148fd6012d7
Autor:
Alexander B. Pine, Matthew L. Meizlish, George Goshua, C-Hong Chang, Hanming Zhang, Jason Bishai, Parveen Bahel, Amisha Patel, Rana Gbyli, Jennifer M. Kwan, Christine H. Won, Christina Price, Charles S. Dela Cruz, Stephanie Halene, David van Dijk, John Hwa, Alfred I. Lee, Hyung J. Chun
Publikováno v:
Pulmonary Circulation, Vol 10 (2020)
Increase in thrombotic and microvascular complications is emerging to be a key feature of patients with critical illness associated with COVID-19 infection. While endotheliopathy is thought to be a key factor of COVID-19-associated coagulopathy, mark
Externí odkaz:
https://doaj.org/article/b63ebb34edc7417bac3ae646450b6612
Autor:
Yujiao Zhao, Matthew Amodio, Brent Vander Wyk, Bram Gerritsen, Mahesh M Kumar, David van Dijk, Kevin Moon, Xiaomei Wang, Anna Malawista, Monique M Richards, Megan E Cahill, Anita Desai, Jayasree Sivadasan, Manjunatha M Venkataswamy, Vasanthapuram Ravi, Erol Fikrig, Priti Kumar, Steven H Kleinstein, Smita Krishnaswamy, Ruth R Montgomery
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 3, p e0008112 (2020)
The genus Flavivirus contains many mosquito-borne human pathogens of global epidemiological importance such as dengue virus, West Nile virus, and Zika virus, which has recently emerged at epidemic levels. Infections with these viruses result in diver
Externí odkaz:
https://doaj.org/article/b845d9f70c124f9aaf91dca3f01f7623
Autor:
Nagarjuna R, Cheemarla, Amelia, Hanron, Joseph R, Fauver, Jason, Bishai, Timothy A, Watkins, Anderson F, Brito, Dejian, Zhao, Tara, Alpert, Chantal B F, Vogels, Albert I, Ko, Wade L, Schulz, Marie L, Landry, Nathan D, Grubaugh, David, van Dijk, Ellen F, Foxman
Publikováno v:
The Lancet Microbe. 4:e38-e46
Symptomatic patients who test negative for common viruses are an important possible source of unrecognised or emerging pathogens, but metagenomic sequencing of all samples is inefficient because of the low likelihood of finding a pathogen in any give
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25bd778901287c9134316290fed323a5
https://doi.org/10.1016/s2666-5247(22)00296-8
https://doi.org/10.1016/s2666-5247(22)00296-8