Zobrazeno 1 - 10
of 19
pro vyhledávání: '"David, Vetvicka"'
Publikováno v:
Life, Vol 13, Iss 2, p 305 (2023)
This updated review aims to describe the current status in the development of liposome-based systems for the targeted delivery of phthalocyanines for photodynamic therapy (PDT). Although a number of other drug delivery systems (DDS) can be found in t
Externí odkaz:
https://doaj.org/article/6dead8b87881453da0771b5ea1d24f10
Autor:
David Vetvicka, Ladislav Sivak, Yu Hang, David Oupický, Raj Kumar, Rubayat Islam Khan, Chinmay M. Jogdeo
Publikováno v:
Journal of Controlled Release. 331:246-259
Despite intensive research efforts and development of numerous new anticancer drugs and treatment strategies over the past decades, there has been only very limited improvement in overall patient survival and in effective treatment options for pancre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8acc51950a6ef9cce70a97cc1eea7593
https://doi.org/10.1016/j.jconrel.2021.01.020
https://doi.org/10.1016/j.jconrel.2021.01.020
Autor:
Michal Zabrodsky, Pavla Pouckova, Martina Kabesova, Jiri Benes, Tomas Olejar, Jan Bouček, David Vetvicka
Publikováno v:
Anticancer Research. 40:349-356
BACKGROUND/AIM Follicle-stimulating hormone receptor (FSHr), expressed on endothelial cells of vessels in different malignant tumors, has been recently investigated as a potential pan-receptor of cancer treatment. However, the expression of this rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0e73b14453be70c39ba0cd50b21827c
https://doi.org/10.21873/anticanres.13959
https://doi.org/10.21873/anticanres.13959
Publikováno v:
Anticancer Research. 39:3323-3339
The focus of this review is to describe the state-of-art in the development of innovative drug delivery systems for phthalocyanines as photosensitizers for photodynamic therapy (PDT). PDT is a medical treatment combining photosensitizers (PSs) activa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ce1dd57a7e80aa5571709ac9671179b
https://doi.org/10.21873/anticanres.13475
https://doi.org/10.21873/anticanres.13475
Autor:
Jiri Panek, David Vetvicka, Michaela Nováková, Sergey K. Filippov, Hana Macková, Jan Kučka, Martin Hruby, Karel Ulbrich
Publikováno v:
Macromolecular Bioscience. 10:916-924
Thermoresponsive polymer micelles are promising drug and radionuclide carriers with a strong passive targeting effect into solid tumors. We have synthesized ABA triblock copolymers poly[2-methyl-2-oxazoline-block-(2-isopropyl-2-oxazoline-co-2-butyl-2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cfbde691a0ddd4dafc084a17664088ef
https://doi.org/10.1002/mabi.201000034
https://doi.org/10.1002/mabi.201000034
Autor:
Marek Kovar, Miroslav Vetrik, Ondrej Hovorka, Blanka Rihova, Tomáš Etrych, David Vetvicka, Martin Hruby, Lubomir Kovar, Karel Ulbrich
Publikováno v:
Bioconjugate Chemistry. 20:2090-2097
The main limitation of contemporary anticancer chemotherapy remains to be the insufficient specificity of the drugs for tumor tissue, which decreases the maximum tolerated dose due to severe side effects. Micellar drug delivery systems based on amphi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9140f1dba29cb1e87e9b9e6e2851b398
https://doi.org/10.1021/bc900212k
https://doi.org/10.1021/bc900212k
Autor:
Göran Karlsson, Karel Ulbrich, Jan Kučka, Miroslav Vetrik, Sergey K. Filippov, David Vetvicka, Cestmir Konak, Hana Macková, Martin Hruby, Blanka Rihova, Katarina Edwards
Publikováno v:
Macromolecular Bioscience. 9:1016-1027
Novel polymer micelles, prepared by self-assembling thermoresponsive poly(N-isopropylacrylamide)-graft-poly[N-(2-hydroxypropyl)methacrylamide] copolymers with hydrolytically degradable N-glycosylamine groups between the polymer blocks are proposed fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d0babb3696529ec0793ca2f9389e348
https://doi.org/10.1002/mabi.200900083
https://doi.org/10.1002/mabi.200900083
Autor:
Tomas, Olejar, David, Vetvicka, Marie, Zadinova, Pavla, Pouckova, Jaromir, Kukal, Petr, Jezek, Radoslav, Matej
Publikováno v:
Anticancer research. 34(7)
We investigated differences of metastatic spread of normal proteinase-activated receptor-2 (Par2+/+) melanoma B16 in Par2-/- (knock-out) animals compared to C57Bl6 mice.Nine knock-out mice B6.Cg-F2rl1tm1Mslb/J (Par2-/-) and nine C57Bl6/J controls wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f71621f3cf56859f0b761488bd49a20b
https://pubmed.ncbi.nlm.nih.gov/24982362
https://pubmed.ncbi.nlm.nih.gov/24982362
Autor:
Karol, Sutoris, Jan, Rakusan, Marie, Karaskova, Jana, Mattova, Jiri, Benes, Milos, Nekvasil, Petr, Jezek, Marie, Zadinova, Pavla, Pouckova, David, Vetvicka
Publikováno v:
Anticancer research. 33(4)
Clinically-approved anticancer photodynamic therapy (PDT) is now extensively studied for various cancer diagnoses. We focused on the treatment efficacy of topical administration of hydroxy-aluminum phthalocyanine (AlOH-PC) entrapped in liposomes agai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2e3ca49617ecae9b1b6b350ecc7f6539
https://pubmed.ncbi.nlm.nih.gov/23564798
https://pubmed.ncbi.nlm.nih.gov/23564798
Ellipticine-aimed polymer-conjugated auger electron emitter: multistage organelle targeting approach
Autor:
Martin Hruby, Lubomir Kovar, David Vetvicka, Martin Studenovsky, Blanka Rihova, Ondrej Sedlacek, Karel Ulbrich, Jan Kučka
Publikováno v:
Bioconjugate chemistry. 22(6)
Radioactive decay of some radionuclides produces a shower of Auger electrons, potent ionizing radiation within a very short range in living tissue (typically ca. 100 nm). Therefore, they must be brought to DNA-containing cell compartments and prefere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04dace0dccb56f9803296dc25361f8fa
https://pubmed.ncbi.nlm.nih.gov/21513348
https://pubmed.ncbi.nlm.nih.gov/21513348