Zobrazeno 1 - 10
of 22
pro vyhledávání: '"David, Van Ly"'
Autor:
Karosham D. Reddy, Sandra Rutting, Corry-Anke Brandsma, Dikaia Xenaki, Jack Bozier, Brian G. Oliver, Yik Lung Chan, Hui Chen, Razia Zakarya, Ian M. Adcock, Roy R Woldhuis, David Van Ly
Publikováno v:
Thorax, 76(7), 647-655. BMJ PUBLISHING GROUP
RationaleIn COPD, small airway fibrosis occurs due to increased extracellular matrix (ECM) deposition in and around the airway smooth muscle (ASM) layer. Studies of immune cells and peripheral lung tissue have shown that epigenetic changes occur in C
Autor:
Mark Read, V. Pragathi Masamsetti, Paul Timpson, Noa Lamm, Max Nobis, Scott G. Page, Anthony J. Cesare, Maté Biro, David Van Ly
Publikováno v:
Nature Cell Biology. 22:1460-1470
Filamentous actin (F-actin) provides cells with mechanical support and promotes the mobility of intracellular structures. Although F-actin is traditionally considered to be cytoplasmic, here we reveal that nuclear F-actin participates in the replicat
Autor:
Afshan McCarthy, Robert Blassberg, Georgia R. Kafer, Steven Howell, James Briscoe, Anthony J. Cesare, David Van Ly, Paulina Marzec, Phil Ruis, Kathy K. Niakan, Simon J. Boulton, Valerie Borel, Ambrosius P. Snijders
Publikováno v:
Nature
Mammalian telomeres protect chromosome ends from aberrant DNA repair1. TRF2, a component of the telomere-specific shelterin protein complex, facilitates end protection through sequestration of the terminal telomere repeat sequence within a lariat T-l
Autor:
David Van Ly, Alen Faiz, Christine Jenkins, Ben Crossett, Judith L Black, Brent McParland, Janette K Burgess, Brian G G Oliver
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e56058 (2013)
Rhinovirus (RV) infections account for approximately two thirds of all virus-induced asthma exacerbations and often result in an impaired response to β2 agonist therapy. Using an in vitro model of RV infection, we investigated the mechanisms underly
Externí odkaz:
https://doaj.org/article/0b7931eb10c44f7d82117f181d73dadd
Autor:
Robyn Lukeis, Duo Wang, Robert Max Conway, Sharron Liang, Svetlana Cherepanoff, Li-Anne Lim, Michael Giblin, David Van Ly, Luke B. Hesson
Publikováno v:
Ocul Oncol Pathol
Uveal melanoma (UM) is the commonest primary intraocular malignancy in adults. There is limited published data on lipid production in UM. Here, we describe the clinical, histological, immunohistochemical, and molecular findings in a ciliochoroidal me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dad387ee307b8f0f8aed8a87116d7f60
https://europepmc.org/articles/PMC7772867/
https://europepmc.org/articles/PMC7772867/
Autor:
Noa, Lamm, Mark N, Read, Max, Nobis, David, Van Ly, Scott G, Page, V Pragathi, Masamsetti, Paul, Timpson, Maté, Biro, Anthony J, Cesare
Publikováno v:
Nature cell biology. 22(12)
Filamentous actin (F-actin) provides cells with mechanical support and promotes the mobility of intracellular structures. Although F-actin is traditionally considered to be cytoplasmic, here we reveal that nuclear F-actin participates in the replicat
Autor:
Pol Margalef, Anthony J. Cesare, Valerie Borel, Panagiotis Kotsantis, Dipanjan Chowdhury, Ambrosius P. Snijders, Grzegorz Sarek, Helen R. Flynn, David Van Ly, Phil Ruis, Simon J. Boulton, Xiaofeng Zheng
Publikováno v:
Nature
The protection of telomere ends by the shelterin complex prevents DNA damage signalling and promiscuous repair at chromosome ends. Evidence suggests that the 3′ single-stranded telomere end can assemble into a lasso-like t-loop configuration1,2, wh
Autor:
Patrick C. Reading, Dominik Hartl, Brian G. Oliver, David Van Ly, Janette K. Burgess, Francesca Tang, Kirsten Spann, Katherine J. Baines
Publikováno v:
Respirology, 21(1), 172-179. Wiley
© 2015 The Authors. Respirology published by Wiley Publishing Asia Pty Ltd on behalf of Asian Pacific Society of Respirology. Background and objective Respiratory viral infections are a major cause of asthma exacerbations. Neutrophils accumulate in
Autor:
Ronnie Ren Jie Low, Katharina Gaus, Tara K. Bartolec, David Van Ly, Hilda A. Pickett, Anthony J. Cesare, Georgia R. Kafer, Sonja Frölich
SUMMARYWe used super-resolution microscopy to investigate the role of macromolecular telomere structure in chromosome end protection. In murine and human cells with reduced TRF2, we find that ATM-activation at chromosome ends occurs with a structural
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2da723aa90b29c14bdb245e54ace2111
Autor:
David Van Ly, Brian G. Oliver
Publikováno v:
Current Drug Delivery. 12:9-15
There is an enormous drive to refine therapeutic designs and delivery systems, but in this review we ask if this is always the right direction? We choose to play devil's advocate, and argue that refining drug design is not always needed, and what is