Zobrazeno 1 - 10
of 56
pro vyhledávání: '"David, Stellwagen"'
Autor:
Karl Foley, Haider Altimimi, Hailong Hou, Yu Zhang, Cody McKee, Makaía M. Papasergi-Scott, Hongtian Yang, Abigail Mayer, Nancy Ward, David M. MacLean, Angus C. Nairn, David Stellwagen, Houhui Xia
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 14 (2022)
Inhibitor-2 (I-2) is a prototypic inhibitor of protein phosphatase-1 (PP1), a major serine-threonine phosphatase that regulates synaptic plasticity and learning and memory. Although I-2 is a potent inhibitor of PP1 in vitro, our previous work has elu
Externí odkaz:
https://doaj.org/article/c086457f6f344661aadfe21d54e67f5d
Autor:
Mai Sakai, Zhiqian Yu, Ryo Hirayama, Masa Nakasato, Yoshie Kikuchi, Chiaki Ono, Hiroshi Komatsu, Miharu Nakanishi, Hatsumi Yoshii, David Stellwagen, Tomoyuki Furuyashiki, Masaaki Komatsu, Hiroaki Tomita
Publikováno v:
Neural Plasticity, Vol 2022 (2022)
Major depressive disorder (MDD) is associated with repeated exposure to environmental stress. Autophagy is activated under various stress conditions that are associated with several diseases in the brain. This study was aimed at elucidating the autop
Externí odkaz:
https://doaj.org/article/185fa5bf209a4df9a6f5b2bee9476b45
Autor:
Mai Sakai, Zhiqian Yu, Masayuki Taniguchi, Rosanne Picotin, Nanami Oyama, David Stellwagen, Chiaki Ono, Yoshie Kikuchi, Ko Matsui, Miharu Nakanishi, Hatsumi Yoshii, Tomoyuki Furuyashiki, Takaaki Abe, Hiroaki Tomita
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 3798 (2023)
N-acetylcysteine (NAC) is an antioxidant that prevents tumor necrosis factor (TNF)-α-induced cell death, but it also acts as a pro-oxidant, promoting reactive oxygen species independent apoptosis. Although there is plausible preclinical evidence for
Externí odkaz:
https://doaj.org/article/49bc4b8cf1ac497ca00d410896b44e34
Autor:
Renu Heir, David Stellwagen
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
Since it was first described almost 30 years ago, homeostatic synaptic plasticity (HSP) has been hypothesized to play a key role in maintaining neuronal circuit function in both developing and adult animals. While well characterized in vitro, determi
Externí odkaz:
https://doaj.org/article/17f4f64ee537443ab7efe83a52613364
Autor:
Christopher K. Salmon, Horia Pribiag, Claire Gizowski, W. Todd Farmer, Scott Cameron, Emma V. Jones, Vivek Mahadevan, Charles W. Bourque, David Stellwagen, Melanie A. Woodin, Keith K. Murai
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
γ-Aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mature brain but has the paradoxical property of depolarizing neurons during early development. Depolarization provided by GABAA transmission during this early phase regulates
Externí odkaz:
https://doaj.org/article/d8b168c9aebd402997561d562df8c290
Publikováno v:
Molecular Psychiatry. 27:4474-4484
Acute stress triggers plasticity of forebrain synapses as well as behavioral changes. Here we reveal that Tumor Necrosis Factor α (TNF) is a required downstream mediator of the stress response in mice, necessary for stress-induced synaptic potentiat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a927b9d8ea4ad457086993b85ecb0d6c
https://doi.org/10.1038/s41380-022-01737-x
https://doi.org/10.1038/s41380-022-01737-x
Autor:
Julien Chambon, Pragya Komal, Gil M. Lewitus, Gina M. Kemp, Simone Valade, Houaria Adaïdi, Noura Al Bistami, David Stellwagen
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience.
Huntington's disease (HD) is a neurodegenerative disease caused by a polyglutamine expansion in the huntingtin gene. Neurodegeneration first occurs in the striatum, accompanied by an elevation in inflammatory cytokines. Using the presymptomatic male
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7fcdd4f5b14dba5156e545f40ac749b
https://pubmed.ncbi.nlm.nih.gov/36517241
https://pubmed.ncbi.nlm.nih.gov/36517241
Autor:
Philip A. Feinberg, Shannon C. Becker, Leeyup Chung, Loris Ferrari, David Stellwagen, Christelle Anaclet, Violeta Durán-Laforet, Travis E. Faust, Rachita K. Sumbria, Dorothy P. Schafer
Publikováno v:
J Neurosci
Interferon regulatory factor 8 (IRF8) is a transcription factor necessary for the maturation of microglia, as well as other peripheral immune cells. It also regulates the transition of microglia and other immune cells to a pro-inflammatory phenotype.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5026e33398d9e72dde9db2ded2fbaa0
https://europepmc.org/articles/PMC9374154/
https://europepmc.org/articles/PMC9374154/
Autor:
Denise Cook, Erin Nuro, Emma V. Jones, Haider F. Altimimi, W. Todd Farmer, Valentina Gandin, Edith Hanna, Ruiting Zong, Alessandro Barbon, David L. Nelson, Ivan Topisirovic, Joseph Rochford, David Stellwagen, Jean-Claude Béïque, Keith K. Murai
Publikováno v:
Cell Reports, Vol 9, Iss 4, Pp 1402-1416 (2014)
Translational control of mRNAs allows for rapid and selective changes in synaptic protein expression that are required for long-lasting plasticity and memory formation in the brain. Fragile X Related Protein 1 (FXR1P) is an RNA-binding protein that c
Externí odkaz:
https://doaj.org/article/539896c5a668445d8f635b64d2926dcd
Autor:
Karl Foley, Haider Altimimi, Hailong Hou, Yu Zhang, Cody McKee, Makaía M. Papasergi-Scott, Hongtian Yang, Abigail Mayer, Nancy Ward, David M. MacLean, Angus C. Nairn, David Stellwagen, Houhui Xia
Inhibitor-2 (I-2) is a prototypic inhibitor of protein phosphatase-1 (PP1), a major serine-threonine phosphatase that regulates synaptic plasticity and learning and memory. Although I-2 is a potent inhibitor of PP1 in vitro, our previous work has elu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17c0a884b7cbf2365f69edec67d359ee
https://doi.org/10.1101/2022.02.10.480004
https://doi.org/10.1101/2022.02.10.480004