Zobrazeno 1 - 10
of 89
pro vyhledávání: '"David, Spanswick"'
Autor:
Mark J. Wall, Emily Hill, Robert Huckstepp, Kerry Barkan, Giuseppe Deganutti, Michele Leuenberger, Barbara Preti, Ian Winfield, Sabrina Carvalho, Anna Suchankova, Haifeng Wei, Dewi Safitri, Xianglin Huang, Wendy Imlach, Circe La Mache, Eve Dean, Cherise Hume, Stephanie Hayward, Jess Oliver, Fei-Yue Zhao, David Spanswick, Christopher A. Reynolds, Martin Lochner, Graham Ladds, Bruno G. Frenguelli
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)
Wall et al. describe the selective activation of an adenosine A1 receptor-mediated intracellular pathway that provides potent analgesia in the absence of sedation or cardiorespiratory depression, paving the way for novel medicines based on the far-re
Externí odkaz:
https://doaj.org/article/248fd0638f5942beb0219612bf9fe670
Autor:
Vanessa R. Haynes, Natalie J. Michael, Marco van den Top, Fei-Yue Zhao, Russell D. Brown, David De Souza, Garron T. Dodd, David Spanswick, Matthew J. Watt
Publikováno v:
Molecular Metabolism, Vol 34, Iss , Pp 54-71 (2020)
Objectives: Nutrient sensing by hypothalamic neurons is critical for the regulation of food intake and energy expenditure. We aimed to identify long- and medium-chain fatty acid species transported into the brain, their effects on energy balance, and
Externí odkaz:
https://doaj.org/article/090fce1d57f8401b9e992de5fd12af30
Autor:
Natalie Jane Michael, Stephanie Elise Simonds, Marco van den Top, Michael Alexander Cowley, David Spanswick
Publikováno v:
Molecular Metabolism, Vol 6, Iss 10, Pp 1103-1112 (2017)
Objective: The mitochondrial uncoupling agent 2,4-dinitrophenol (DNP), historically used as a treatment for obesity, is known to cross the blood-brain-barrier, but its effects on central neural circuits controlling body weight are largely unknown. As
Externí odkaz:
https://doaj.org/article/d9f88e3372db46ff837bd4d45265dab5
Autor:
Adam C. Kennedy, Alessia Belgi, Benjamin W. Husselbee, David Spanswick, Raymond S. Norton, Andrea J. Robinson
Publikováno v:
Toxins, Vol 12, Iss 8, p 505 (2020)
Several analgesic α-conotoxins have been isolated from marine cone snails. Structural modification of native peptides has provided potent and selective analogues for two of its known biological targets—nicotinic acetylcholine and γ-aminobutyric a
Externí odkaz:
https://doaj.org/article/d94c31a8b04f490c9c6f846e296840c7
Autor:
Garron T Dodd, Natalie J Michael, Robert S Lee-Young, Salvatore P Mangiafico, Jack T Pryor, Astrid C Munder, Stephanie E Simonds, Jens Claus Brüning, Zhong-Yin Zhang, Michael A Cowley, Sofianos Andrikopoulos, Tamas L Horvath, David Spanswick, Tony Tiganis
Publikováno v:
eLife, Vol 7 (2018)
Hypothalamic neurons respond to nutritional cues by altering gene expression and neuronal excitability. The mechanisms that control such adaptive processes remain unclear. Here we define populations of POMC neurons in mice that are activated or inhib
Externí odkaz:
https://doaj.org/article/fab6ed8d6e114ea6b2ada91531963160
Autor:
Pabitra Hriday Patra, Becks Tench, Timna Hitrec, Fiona Holmes, Robert Drake, Serena Cerritelli, David Spanswick, Anthony Edward Pickering
Publikováno v:
Patra, P, Tench, B L, Hitrec, T, Holmes, F E, Drake, R A R, Cerritelli, S, Spanswick, D & Pickering, A E 2022, ' Pro-opiomelanocortin neurons in the nucleus of the solitary tract mediate endorphinergic endogenous analgesia in mice ', PAIN . https://doi.org/10.1097/j.pain.0000000000002802
The nucleus of the solitary tract (NTS) contains pro-opiomelanocortin (POMC) neurons that are 1 of the 2 major sources of β-endorphin in the brain. The functional role of these NTSPOMC neurons in nociceptive and cardiorespiratory function is debated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbaaae4dee8e7244387da476b1e42f2e
https://research-information.bris.ac.uk/ws/files/338038733/Patra_et_al_2022_PAIN_Author_accepted_figs.pdf
https://research-information.bris.ac.uk/ws/files/338038733/Patra_et_al_2022_PAIN_Author_accepted_figs.pdf
Autor:
Sandeep Chhabra, Simon G. Gooding, Alessia Belgi, Raymond S. Norton, David J. Adams, Samuel D. Robinson, James Burnley, Peter Bartels, Fei Yue Zhao, David Spanswick, Andrea J. Robinson, Khaled A. Elnahriry, Mahsa Sadeghi, Han-Shen Tae, Christopher A. MacRaild, Haifeng Wei
Publikováno v:
Journal of Medicinal Chemistry. 64:3222-3233
Several Conus-derived venom peptides are promising lead compounds for the management of neuropathic pain, with α-conotoxins being of particular interest. Modification of the interlocked disulfide framework of α-conotoxin Vc1.1 has been achieved usi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18e7ff4e2677bf08f7477ed2e2896f72
https://doi.org/10.1021/acs.jmedchem.0c02151
https://doi.org/10.1021/acs.jmedchem.0c02151
Autor:
Garron T. Dodd, David P De Souza, Russell D Brown, David Spanswick, Vanessa R. Haynes, Marco van den Top, Natalie J. Michael, Fei-Yue Zhao, Matthew J. Watt
Publikováno v:
Molecular Metabolism
Molecular Metabolism, Vol 34, Iss, Pp 54-71 (2020)
Molecular Metabolism, Vol 34, Iss, Pp 54-71 (2020)
Objectives Nutrient sensing by hypothalamic neurons is critical for the regulation of food intake and energy expenditure. We aimed to identify long- and medium-chain fatty acid species transported into the brain, their effects on energy balance, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa3ae996a2befbf98fb187500b5a9cbd
https://doi.org/10.1016/j.molmet.2020.01.002
https://doi.org/10.1016/j.molmet.2020.01.002
Publikováno v:
Journal of the Formosan Medical Association, Vol 109, Iss 6, Pp 438-445 (2010)
Rats display behavioral signs of neuropathic pain lasting for months in the chronic constriction injury (CCI) model. During intrathecal anesthesia, the administered drugs mainly diffuse directly into the superficial neurons in the spinal dorsal horn.
Externí odkaz:
https://doaj.org/article/dc4b653766cc48a4a478e8d813efd369
Autor:
Matthew J. Sykes, Wendy L. Imlach, Orsolya Kékesi, Yan T. Wong, Fei Yue Zhao, David Spanswick
Publikováno v:
Neuropharmacology. 198
Excitatory and inhibitory neurotransmission within the spinal dorsal horn is tightly controlled to regulate transmission of nociceptive signals to the brain. One aspect of this control is modulation of neuronal activity through cholinergic signaling.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc5220aa2cc7b07b4915dcf5e7318a6a
https://pubmed.ncbi.nlm.nih.gov/34416268
https://pubmed.ncbi.nlm.nih.gov/34416268