The Homeobox Transcription Factor RHOX10 Drives Mouse Spermatogonial Stem Cell Establishment

Autor: Hye-Won Song, Anilkumar Bettegowda, Blue B. Lake, Adrienne H. Zhao, David Skarbrevik, Eric Babajanian, Meena Sukhwani, Eleen Y. Shum, Mimi H. Phan, Terra-Dawn M. Plank, Marcy E. Richardson, Madhuvanthi Ramaiah, Vaishnavi Sridhar, Dirk G. de Rooij, Kyle E. Orwig, Kun Zhang, Miles F. Wilkinson

Publikováno v: Cell Reports, Vol 17, Iss 1, Pp 149-164 (2016)

The developmental origins of most adult stem cells are poorly understood. Here, we report the identification of a transcription factor—RHOX10—critical for the initial establishment of spermatogonial stem cells (SSCs). Conditional loss of the enti

Externí odkaz: https://doaj.org/article/6d7587bd1d6544e09806e0302cbca845

The Rhox gene cluster suppresses germline LINE1 transposition

Autor: Fred H. Gage, Eric Babajanian, Tracy A. Bedrosian, Matthew E Kim, Hye-Won Song, David Skarbrevik, Miles F. Wilkinson, Kun Tan

Publikováno v: Proceedings of the National Academy of Sciences. 118

Transposable elements (TEs) are mobile sequences that engender widespread mutations and thus are a major hazard that must be silenced. The most abundant active class of TEs in mammalian genomes is long interspersed element class 1 (LINE1). Here, we r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dffe494c1cfd671af2aa758d232e8f22
https://doi.org/10.1073/pnas.2024785118

Chromatin Modification and Global Transcriptional Silencing in the Oocyte Mediated by the mRNA Decay Activator ZFP36L2

Autor: Jennifer N Dumdie, Jens Lykke-Andersen, David Skarbrevik, Sergio Mora-Castilla, Louise C. Laurent, Kyucheol Cho, Deborah J. Stumpo, Perry J. Blackshear, Heidi Cook-Andersen, Miles F. Wilkinson, Madhuvanthi Ramaiah

Publikováno v: Dumdie, Jennifer N; Cho, Kyucheol; Ramaiah, Madhuvanthi; Skarbrevik, David; Mora-Castilla, Sergio; Stumpo, Deborah J; et al.(2018). Chromatin Modification and Global Transcriptional Silencing in the Oocyte Mediated by the mRNA Decay Activator ZFP36L2.. Developmental cell, 44(3), 392-402.e7. doi: 10.1016/j.devcel.2018.01.006. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/9bp7w5p9
Developmental cell, vol 44, iss 3

Global transcriptional silencing is a highly conserved mechanism central to the oocyte-to-embryo transition. We report the unexpected discovery that global transcriptional silencing in oocytes depends on an mRNA decay activator. Oocyte-specific loss

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcbefb8670a42700b4f95a81e7736d1a
http://www.escholarship.org/uc/item/9bp7w5p9

The Homeobox Transcription Factor RHOX10 Drives Mouse Spermatogonial Stem Cell Establishment

Autor: Adrienne H. Zhao, Eric Babajanian, Eleen Shum, Vaishnavi Sridhar, Marcy E. Richardson, Terra-Dawn M. Plank, Hye-Won Song, Meena Sukhwani, Dirk G. de Rooij, Anilkumar Bettegowda, David Skarbrevik, Blue B. Lake, Mimi H. Phan, Kyle E. Orwig, Kun Zhang, Madhuvanthi Ramaiah, Miles F. Wilkinson

Publikováno v: Cell Reports, Vol 17, Iss 1, Pp 149-164 (2016)
Cell reports, vol 17, iss 1

SummaryThe developmental origins of most adult stem cells are poorly understood. Here, we report the identification of a transcription factor—RHOX10—critical for the initial establishment of spermatogonial stem cells (SSCs). Conditional loss of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::191548e4ac2058f874aad4a6e6afc8b0
https://pubmed.ncbi.nlm.nih.gov/27908878