Zobrazeno 1 - 10
of 219
pro vyhledávání: '"David, Safronetz"'
Autor:
Abd’jeleel Salawudeen, Geoff Soule, Nikesh Tailor, Levi Klassen, Jonathan Audet, Angela Sloan, Yvon Deschambault, David Safronetz
Publikováno v:
Emerging Infectious Diseases, Vol 30, Iss 5, Pp 1004-1008 (2024)
We evaluated the in vitro effects of lyophilization for 2 vesicular stomatitis virus–based vaccines by using 3 stabilizing formulations and demonstrated protective immunity of lyophilized/reconstituted vaccine in guinea pigs. Lyophilization increas
Externí odkaz:
https://doaj.org/article/e9d4dcae17374f0cbb3dff803874c7ff
Autor:
Andrew L. Webb, Brayden G. Schindell, Geoff Soule, Abu B. Siddik, Bernard Abrenica, Harram Memon, Ruey-Chyi Su, David Safronetz, Jason Kindrachuk
Publikováno v:
npj Viruses, Vol 2, Iss 1, Pp 1-14 (2024)
Abstract Ebola virus (EBOV) is able to persist and actively replicate in the reproductive tract of male disease survivors months or years after recovery from Ebola virus disease (EVD)1. Persistent EBOV infections are usually asymptomatic and can be t
Externí odkaz:
https://doaj.org/article/f42f61e661034cfcb46478bbba1b09c9
Autor:
Wenguang Cao, Shihua He, Guodong Liu, Helene Schulz, Karla Emeterio, Michael Chan, Kevin Tierney, Kim Azaransky, Geoff Soule, Nikesh Tailor, Abdjeleel Salawudeen, Rick Nichols, Joan Fusco, David Safronetz, Logan Banadyga
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-9 (2023)
Abstract Recombinant vesicular stomatitis viruses (rVSVs) engineered to express heterologous viral glycoproteins have proven to be remarkably effective vaccines. Indeed, rVSV-EBOV, which expresses the Ebola virus (EBOV) glycoprotein, recently receive
Externí odkaz:
https://doaj.org/article/085daf7c13654dfeb1807e18d2a02067
Autor:
Sathya N. Thulasi Raman, Adrian Zetner, Anwar M. Hashem, Devina Patel, Jianguo Wu, Caroline Gravel, Jun Gao, Wanyue Zhang, Annabelle Pfeifle, Levi Tamming, Karan Parikh, Jingxin Cao, Roger Tam, David Safronetz, Wangxue Chen, Michael J.W. Johnston, Lisheng Wang, Simon Sauve, Michael Rosu-Myles, Gary Van Domselaar, Xuguang Li
Publikováno v:
Emerging Microbes and Infections, Vol 12, Iss 1 (2023)
ABSTRACTInfluenza and Respiratory Syncytial virus (RSV) infections together contribute significantly to the burden of acute lower respiratory tract infections. Despite the disease burden, no approved RSV vaccine is available. While approved vaccines
Externí odkaz:
https://doaj.org/article/067d067bb5254d068855c61eab6f8a16
Autor:
Bryce M. Warner, Mable Chan, Nikesh Tailor, Robert Vendramelli, Jonathan Audet, Courtney Meilleur, Thang Truong, Lauren Garnett, Marnie Willman, Geoff Soule, Kevin Tierney, Alixandra Albietz, Estella Moffat, Rick Higgins, Lisa A. Santry, Alexander Leacy, Phuc H. Pham, Jacob G. E. Yates, Yanlong Pei, David Safronetz, James E. Strong, Leonardo Susta, Carissa Embury-Hyatt, Sarah K. Wootton, Darwyn Kobasa
Publikováno v:
Vaccines, Vol 12, Iss 4, p 404 (2024)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged following an outbreak of unexplained viral illness in China in late 2019. Since then, it has spread globally causing a pandemic that has resulted in millions of deaths and has had e
Externí odkaz:
https://doaj.org/article/5e4cccc3f31e4e15bd81f344156fe762
Autor:
Joshua Marceau, David Safronetz, Cynthia Martellaro, Andrea Marzi, Kyle Rosenke, Heinz Feldmann
Publikováno v:
Viruses, Vol 16, Iss 2, p 279 (2024)
Orthohantaviruses may cause hemorrhagic fever with renal syndrome or hantavirus cardiopulmonary syndrome. Andes virus (ANDV) is the only orthohantavirus associated with human–human transmission. Therefore, emergency vaccination would be a valuable
Externí odkaz:
https://doaj.org/article/51d114e90f5e4a1abcf81c7b40f785c0
Autor:
Yvon Deschambault, Levi Klassen, Geoff Soule, Kevin Tierney, Kimberly Azaransky, Angela Sloan, David Safronetz
Publikováno v:
Emerging Infectious Diseases, Vol 29, Iss 4, Pp 858-860 (2023)
The global spread of monkeypox virus has raised concerns over the establishment of novel enzootic reservoirs in expanded geographic regions. We demonstrate that although deer mice are permissive to experimental infection with clade I and II monkeypox
Externí odkaz:
https://doaj.org/article/a7969eafb16043539a537ab54a5124a6
Autor:
Kaye Quizon, Kimberly Holloway, Mahmood Iranpour, Bryce M. Warner, Yvon Deschambault, Geoff Soule, Kevin Tierney, Darwyn Kobasa, Angela Sloan, David Safronetz
Publikováno v:
Emerging Infectious Diseases, Vol 28, Iss 9, Pp 1882-1885 (2022)
We demonstrate that 6 distinct Peromyscus rodent species are permissive to experimental infection with Sin Nombre orthohantavirus (SNV). Viral RNA and SNV antibodies were detected in members of all 6 species. P. leucopus mice demonstrated markedly hi
Externí odkaz:
https://doaj.org/article/62cfceb8c9194741a1039bd12835caeb
Autor:
Laura P. van Lieshout, Amira D. Rghei, Wenguang Cao, Shihua He, Geoff Soule, Wenjun Zhu, Sylvia P. Thomas, Debra Sorensen, Kathy Frost, Kevin Tierney, Brad Thompson, Stephanie Booth, David Safronetz, Raveendra R. Kulkarni, Byram W. Bridle, Xiangguo Qiu, Logan Banadyga, Sarah K. Wootton
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 26, Iss , Pp 505-518 (2022)
Filoviruses cause severe hemorrhagic fever with case fatality rates as high as 90%. Filovirus-specific monoclonal antibodies (mAbs) confer protection in nonhuman primates as late as 5 days after challenge, and FDA-approved mAbs REGN-EB3 and mAb114 ha
Externí odkaz:
https://doaj.org/article/50cc389f7095494bba9d58a113335768
Autor:
Kyle LeBlanc, Jessie Lynch, Christine Layne, Robert Vendramelli, Angela Sloan, Nikesh Tailor, Yvon Deschambault, Fushun Zhang, Darwyn Kobasa, David Safronetz, Yan Xiang, Jingxin Cao
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 3 (2023)
ABSTRACT Coronaviruses (CoVs), including severe acute respiratory syndrome CoV (SARS-CoV), Middle East respiratory syndrome CoV (MERS-CoV), and SARS-CoV-2, produce double-stranded RNA (dsRNA) that activates antiviral pathways such as PKR and OAS/RNas
Externí odkaz:
https://doaj.org/article/73fcb0d71715445dbe5f0a8ebe2b1962