Zobrazeno 1 - 10 of 15 pro vyhledávání: '"David, Rowitch"'
1
Akademický článek
Time-resolved single-cell RNAseq profiling identifies a novel Fabp5+ subpopulation of inflammatory myeloid cells with delayed cytotoxic profile in chronic spinal cord injury
Autor: Regan Hamel, Luca Peruzzotti-Jametti, Katherine Ridley, Veronica Testa, Bryan Yu, David Rowitch, John C. Marioni, Stefano Pluchino
Publikováno v: Heliyon, Vol 9, Iss 8, Pp e18339- (2023)
Traumatic spinal cord injuries (SCI) are a group of highly debilitating pathologies affecting thousands annually, and adversely affecting quality of life. Currently, no fully restorative therapies exist, and SCI still results in significant personal,
Externí odkaz: https://doaj.org/article/f5c637943179487984dbc301440017d0
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2
Akademický článek
Sirt1 regulates glial progenitor proliferation and regeneration in white matter after neonatal brain injury
Autor: Beata Jablonska, Marcin Gierdalski, Li-Jin Chew, Teresa Hawley, Mackenzie Catron, Arturo Lichauco, Juan Cabrera-Luque, Tracy Yuen, David Rowitch, Vittorio Gallo
Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
Oligodendrocyte progenitor cell (OPC) proliferation is crucial for regeneration after hypoxic lesions in mice, a model of diffuse white matter injury of premature infants. Here, the authors show that the histone deacetylase Sirt1 is a Cdk2-dependent
Externí odkaz: https://doaj.org/article/97db07f9d9a64b86bd58146875a5c0da
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3
Data from A Novel Somatic Mouse Model to Survey Tumorigenic Potential Applied to the Hedgehog Pathway
Autor: Andrew P. McMahon, David Rowitch, Roderick T. Bronson, Sarah P. Thayer, Elena Y. Rakhlin, Keith L. Ligon, Junhao Mao
We report a novel mouse model for the generation of sporadic tumors and show the efficiency of this approach by surveying Hedgehog (Hh)–related tumors. Up-regulation of the Hh pathway is achieved by conditionally regulated expression of an activate
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::329575beab790c689c6e9bd4672e17de
https://doi.org/10.1158/0008-5472.c.6494432
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7
Silencing neuroinflammatory reactive astrocyte activating factors ameliorates disease outcomes in perinatal white matter injury
Autor: Patricia Renz, Daniel Surbek, Valérie Haesler, Vera Tscherrig, Eric J Huang, Manideep Chavali, Shane Liddelow, David Rowitch, Andreina Schoeberlein, Amanda Brosius Lutz
The role of reactive astrocytes in perinatal white matter injury (WMI) is unclear. In a mouse model of WMI, we provide evidence that impairing the formation of aC3-expressing neuroinflammatory reactive astrocyte sub-state rescues myelination and beha
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5e10bb51cd88b8f9790af57137ec4cd1
https://doi.org/10.1101/2022.12.19.521083
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8
Akademický článek
The role of Tal2 and Tal1 in the differentiation of midbrain GABAergic neuron precursors
Autor: Kaia Achim, Paula Peltopuro, Laura Lahti, Hui-Hsin Tsai, Alyssa Zachariah, Mia Åstrand, Marjo Salminen, David Rowitch, Juha Partanen
Publikováno v: Biology Open, Vol 2, Iss 10, Pp 990-997 (2013)
Summary Midbrain- and hindbrain-derived GABAergic interneurons are critical for regulation of sleep, respiratory, sensory-motor and motivational processes, and they are implicated in human neurological disorders. However, the precise mechanisms that
Externí odkaz: https://doaj.org/article/cd978e618be34e75ab79551463cd1a35
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