Zobrazeno 1 - 10
of 138
pro vyhledávání: '"David, Rampe"'
Autor:
Ulrich Koert, Philipp Reiß
Publikováno v:
Angewandte Chemie. 118:5540-5540
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6b9600ac14e12002d6aed908ad3e709
https://doi.org/10.1002/ange.200685419
https://doi.org/10.1002/ange.200685419
Autor:
Ulrich Koert, Philipp Reiß
Publikováno v:
Angewandte Chemie International Edition. 45:5414-5414
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f70f1ca263198c9c652533b2a457a251
https://doi.org/10.1002/anie.200685419
https://doi.org/10.1002/anie.200685419
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:446-451
Abuse of the common anti-diarrheal loperamide is associated with QT interval prolongation as well as development of the potentially fatal arrhythmia torsades de pointes. The mechanism underlying this cardiotoxicity is high affinity inhibition of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcc46fd2ce619143a94f4c900ecad85e
https://doi.org/10.1016/j.bmcl.2017.12.020
https://doi.org/10.1016/j.bmcl.2017.12.020
Publikováno v:
Journal of Applied Toxicology. 37:445-453
Inhibition of the human ether-a-go-go-related gene (hERG) K+ channel by drugs leads to QT prolongation on the electrocardiogram and can result in serious cardiac arrhythmia. For this reason, screening of drugs on hERG is mandatory during the drug dev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f31da1b3cd5caba6cf6e361605a365d
https://doi.org/10.1002/jat.3377
https://doi.org/10.1002/jat.3377
Autor:
Reiß, Philipp, Koert, Ulrich
Publikováno v:
Angewandte Chemie. International Edition; August 2006, Vol. 45 Issue: 33 p5414-5414, 1p
Autor:
Reiß, Philipp, Koert, Ulrich
Publikováno v:
Angewandte Chemie; August 2006, Vol. 118 Issue: 33 p5540-5540, 1p
Publikováno v:
ASSAY and Drug Development Technologies. 12:352-360
Human stem cell-derived cardiomyocytes provide a cellular model for the study of electrophysiology in the human heart and are finding a niche in the field of safety pharmacology for predicting proarrhythmia. The cardiac L-type Ca2+ channel is an impo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::763b2bc4d2cd4e37c311bb85956a95d7
https://doi.org/10.1089/adt.2014.596
https://doi.org/10.1089/adt.2014.596
Publikováno v:
Naunyn-Schmiedeberg's archives of pharmacology. 389(10)
Loperamide is a μ-opioid receptor agonist commonly used to treat diarrhea and often available as an over-the-counter medication. Recently, numerous reports of QRS widening accompanied by dramatic QT interval prolongation, torsades de pointe arrhythm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::602ad69a0141232658e8af5c9450c92c
https://pubmed.ncbi.nlm.nih.gov/27530870
https://pubmed.ncbi.nlm.nih.gov/27530870
Publikováno v:
Journal of applied toxicology : JAT. 37(4)
Inhibition of the human ether-a-go-go-related gene (hERG) K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e8cd041e34b569ee4bd4c78a17c943c0
https://pubmed.ncbi.nlm.nih.gov/27553911
https://pubmed.ncbi.nlm.nih.gov/27553911
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 341:510-517
Human stem cell-derived cardiomyocytes provide new models for studying the ion channel pharmacology of human cardiac cells for both drug discovery and safety pharmacology purposes. However, detailed pharmacological characterization of ion channels in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6cde526b606c59d6c0a676821c9dceea
https://doi.org/10.1124/jpet.112.192609
https://doi.org/10.1124/jpet.112.192609