Zobrazeno 1 - 10
of 14
pro vyhledávání: '"David, Printzenhoff"'
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0161450 (2016)
The voltage dependent sodium channel Nav1.9, is expressed preferentially in peripheral sensory neurons and has been linked to human genetic pain disorders, which makes it target of interest for the development of new pain therapeutics. However, chara
Externí odkaz:
https://doaj.org/article/0a4e951432894c9b88aeb7972ad455b8
Autor:
Aristos J Alexandrou, Adam R Brown, Mark L Chapman, Mark Estacion, Jamie Turner, Malgorzata A Mis, Anna Wilbrey, Elizabeth C Payne, Alex Gutteridge, Peter J Cox, Rachel Doyle, David Printzenhoff, Zhixin Lin, Brian E Marron, Christopher West, Nigel A Swain, R Ian Storer, Paul A Stupple, Neil A Castle, James A Hounshell, Mirko Rivara, Andrew Randall, Sulayman D Dib-Hajj, Douglas Krafte, Stephen G Waxman, Manoj K Patel, Richard P Butt, Edward B Stevens
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0152405 (2016)
Human genetic studies show that the voltage gated sodium channel 1.7 (Nav1.7) is a key molecular determinant of pain sensation. However, defining the Nav1.7 contribution to nociceptive signalling has been hampered by a lack of selective inhibitors. H
Externí odkaz:
https://doaj.org/article/b9af198893454af186b55747950a6251
Autor:
Jianmin Sun, Thomas Ryckmans, David Fengas, Colin R. Rose, M. Scott Johnson, Matthew Corbett, David James Rawson, Nigel Alan Swain, Joseph S. Warmus, Lyn H. Jones, Brian E. Marron, Aristos J. Alexandrou, David Printzenhoff, C. Elizabeth Payne, Bruce M. Bechle, Rubben Torella, Neil A. Castle, Jonathan W. Theile, Elaine Tseng, David C. Blakemore, Andrew Pike, R. Ian Storer, Neil J. Flanagan, Alan Daniel Brown
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:4805-4811
The discovery and selection of a highly potent and selective NaV1.7 inhibitor PF-06456384, designed specifically for intravenous infusion, is disclosed. Extensive in vitro pharmacology and ADME profiling followed by in vivo preclinical PK and efficac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f22618c2c414697df7e81bc63fdf7005
https://doi.org/10.1016/j.bmcl.2017.09.056
https://doi.org/10.1016/j.bmcl.2017.09.056
Autor:
David C. Pryde, Brian E. Marron, Peter J. Cox, C. J. Markworth, Joseph S. Warmus, Christopher William West, David Printzenhoff, S. McMurray, Stupple Paul Anthony, Zhixin Lin, Nigel Alan Swain, Mark L. Chapman, C. E. Payne, Ryoichi Suzuki, Gareth Waldron
Publikováno v:
MedChemComm. 8:1255-1267
In this article, we describe the discovery of an aryl ether series of potent and selective Nav1.3 inhibitors. Based on structural analogy to a similar series of compounds we have previously shown bind to the domain IV voltage sensor region of Nav cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::686aba00c31c3db790fd73e2323a9e86
https://doi.org/10.1039/c7md00131b
https://doi.org/10.1039/c7md00131b
Publikováno v:
British Journal of Pharmacology. 172:4905-4918
Background and purpose Aryl sulfonamide Nav 1.3 or Nav 1.7 voltage-gated sodium (Nav ) channel inhibitors interact with the Domain 4 voltage sensor domain (D4 VSD). During studies to better understand the structure-activity relationship of this inter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2474465a395764297c6041cd894a21fa
https://doi.org/10.1111/bph.13259
https://doi.org/10.1111/bph.13259
Autor:
Rosemarie Roeloffs, Anthony W Bannon, Adam R. Brown, Alexandre J.C. Loucif, Aristos J. Alexandrou, Anthony J. Kirkup, Mathew D Fuller, Gillian Stockbridge, Edward B. Stevens, David Printzenhoff, Praveen Anand, Steve England, Claire Elizabeth Payne, Uma Anand, Peter J. Bungay, Aaron C. Gerlach, Mark L. Chapman, Kemp Mark Ian, John H. Mahoney, Rebecca L. Prime, Jonathon W Theile, Brett M Antonio, Richard P. Butt, Sharan K. Bagal
Publikováno v:
British Journal of Pharmacology. 172:2654-2670
Background and Purpose NaV1.8 ion channels have been highlighted as important molecular targets for the design of low MW blockers for the treatment of chronic pain. Here, we describe the effects of PF-01247324, a new generation, selective, orally bio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc8c0db0b158b8bf6fded6eb148ad000
https://doi.org/10.1111/bph.13092
https://doi.org/10.1111/bph.13092
Autor:
R Ian, Storer, Andy, Pike, Nigel A, Swain, Aristos J, Alexandrou, Bruce M, Bechle, David C, Blakemore, Alan D, Brown, Neil A, Castle, Matthew S, Corbett, Neil J, Flanagan, David, Fengas, M Scott, Johnson, Lyn H, Jones, Brian E, Marron, C Elizabeth, Payne, David, Printzenhoff, David J, Rawson, Colin R, Rose, Thomas, Ryckmans, Jianmin, Sun, Jonathan W, Theile, Rubben, Torella, Elaine, Tseng, Joseph S, Warmus
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(21)
The discovery and selection of a highly potent and selective Na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9b1525a17645ac5a672b8a43ff63d92d
https://pubmed.ncbi.nlm.nih.gov/29029933
https://pubmed.ncbi.nlm.nih.gov/29029933
Autor:
Bruce M. Bechle, Stephen Martin Denton, Sebastien Galan, David James Rawson, Marcel J. de Groot, Brian E. Marron, Matthew S Johnson, Jo Hannam, Shoko Nakagawa, Dave Batchelor, Nigel Alan Swain, Steven M Reister, David Ellis, Mark L. Chapman, David Printzenhoff, Sarah J Ransley, Beaudoin Serge, David S. Millan, Christopher W. West, Kenneth John Butcher, R. Ian Storer, Stephen M Gaulier, Stupple Paul Anthony, Andrew Pike, Alan Daniel Brown, Christopher John Markworth, Bruce Brown, Zhixin Lin, Sasaki Kosuke, Paul A. Bradley, Ian Gurrell, Richard P. Butt, Mel Glossop, Ben S. Greener
Publikováno v:
Journal of medicinal chemistry. 60(16)
A series of acidic diaryl ether heterocyclic sulfonamides that are potent and subtype selective NaV1.7 inhibitors is described. Optimization of early lead matter focused on removal of structural alerts, improving metabolic stability and reducing cyto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e78a3f0b6803242d1ea5f4b0b677ac41
https://pubmed.ncbi.nlm.nih.gov/28682065
https://pubmed.ncbi.nlm.nih.gov/28682065
Autor:
Edward B. Stevens, Zhixin Lin, Anna Wilbrey, Stephen G. Waxman, Peter J. Cox, Sulayman D. Dib-Hajj, Mark L. Chapman, Malgorzata A. Mis, Christopher William West, R. Ian Storer, Stupple Paul Anthony, Elizabeth C. Payne, Manoj K. Patel, David Printzenhoff, Andrew D. Randall, James A. Hounshell, Douglas S. Krafte, Jamie Turner, Nigel Alan Swain, Aristos J. Alexandrou, Richard P. Butt, Adam R. Brown, Mark Estacion, Brian E. Marron, Alex Gutteridge, Neil A. Castle, Rachel Doyle, Mirko Rivara
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0152405 (2016)
PLoS ONE
PLoS ONE
Human genetic studies show that the voltage gated sodium channel 1.7 (Nav1.7) is a key molecular determinant of pain sensation. However, defining the Nav1.7 contribution to nociceptive signalling has been hampered by a lack of selective inhibitors. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2675321c19d1f59001ead963da4e18e
http://europepmc.org/articles/PMC4822888?pdf=render
http://europepmc.org/articles/PMC4822888?pdf=render
Autor:
Brett Antonio, Christopher Silvia, Alan D. Wickenden, Shannon G. Zellmer, Neil A. Castle, David Printzenhoff
Publikováno v:
Combinatorial Chemistry & High Throughput Screening. 12:107-122
Voltage dependent sodium channels are widely recognized as valuable targets for the development of therapeutic interventions for neuroexcitatory disorders such as epilepsy and pain as well as cardiac arrhythmias. An ongoing challenge for sodium chann
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf17e8ff2755dbc9bf2f3429eafb189f
https://doi.org/10.2174/138620709787047993
https://doi.org/10.2174/138620709787047993