Výsledky vyhledávání - "David, Penton"

Akademický článek

Macrophages preserve endothelial cell specialization in the adrenal gland to modulate aldosterone secretion and blood pressure

Publikováno v: Cell Reports, Vol 43, Iss 7, Pp 114395- (2024)

Summary: Macrophages play crucial roles in organ-specific functions and homeostasis. In the adrenal gland, macrophages closely associate with sinusoidal capillaries in the aldosterone-producing zona glomerulosa. We demonstrate that macrophages preser

Externí odkaz: https://doaj.org/article/02b69b219d364673aaf81f6bfedf2bb0

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Akademický článek

Calcineurin regulates aldosterone production via dephosphorylation of NFATC4

Autor: Mesut Berber, Sining Leng, Agnieszka Wengi, Denise V. Winter, Alex Odermatt, Felix Beuschlein, Johannes Loffing, David T. Breault, David Penton

Publikováno v: JCI Insight, Vol 8, Iss 14 (2023)

The mineralocorticoid aldosterone, secreted by the adrenal zona glomerulosa (ZG), is critical for life, maintaining ion homeostasis and blood pressure. Therapeutic inhibition of protein phosphatase 3 (calcineurin, Cn) results in inappropriately low p

Externí odkaz: https://doaj.org/article/17c862d14a5b4e46b23bf19918c8d968

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Akademický článek

Characterisation of meteorological drought at sub-catchment scale in Afghanistan using station-observed climate data.

Autor: Yun Chen, David Penton, Fazlul Karim, Santosh Aryal, Shahriar Wahid, Peter Taylor, Susan M Cuddy

Publikováno v: PLoS ONE, Vol 18, Iss 2, p e0280522 (2023)

Droughts have severely affected Afghanistan over the last four decades, leading to critical food shortages where two-thirds of the country's population are in a food crisis. Long years of conflict have lowered the country's ability to deal with hazar

Externí odkaz: https://doaj.org/article/4dd5466711a34db487c6ac89de6dd4b4

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Akademický článek

A Comprehensive Investigation of Steroidogenic Signaling in Classical and New Experimental Cell Models of Adrenocortical Carcinoma

Autor: Sandra Sigala, Christina Bothou, David Penton, Andrea Abate, Mirko Peitzsch, Deborah Cosentini, Guido A. M. Tiberio, Stefan R. Bornstein, Alfredo Berruti, Constanze Hantel

Publikováno v: Cells, Vol 11, Iss 9, p 1439 (2022)

Adrenocortical carcinoma is a heterogeneous and aggressive cancer that originates from steroidogenic cells within the adrenal cortex. In this study, we have assessed for the preclinical gold standard NCI-H295 in direct comparison with the more recent

Externí odkaz: https://doaj.org/article/c77753277dde4360a30f788f6ef8fe71

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Akademický článek

The serine‐threonine kinase PIM3 is an aldosterone‐regulated protein in the distal nephron

Autor: Alessia Spirli, Lydie Cheval, Anne Debonneville, David Penton, Caroline Ronzaud, Marc Maillard, Alain Doucet, Johannes Loffing, Olivier Staub

Publikováno v: Physiological Reports, Vol 7, Iss 15, Pp n/a-n/a (2019)

Abstract The mineralocorticoid hormone aldosterone plays a crucial role in the control of Na+ and K+ balance, blood volume, and arterial blood pressure, by acting in the aldosterone‐sensitive distal nephron (ASDN) and stimulating a complex transcri

Externí odkaz: https://doaj.org/article/297fa8daf6ae48448175fc678497a2ab

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Activation of the kidney sodium chloride cotransporter by the β2-adrenergic receptor agonist salbutamol increases blood pressure

Autor: Johannes Loffing, Robert Little, Søren Brandt Poulsen, Sathish K. Murali, Marleen L. A. Kortenoeven, Lei Cheng, Robert A. Fenton, David Penton, Vladimir V. Matchkov

Publikováno v: Poulsen, S B, Cheng, L, Penton, D, Kortenoeven, M L A, Matchkov, V V, Loffing, J, Little, R, Murali, S K & Fenton, R A 2021, ' Activation of the kidney sodium chloride cotransporter by the β2-adrenergic receptor agonist salbutamol increases blood pressure ', Kidney International, vol. 100, no. 2, pp. 321-335 . https://doi.org/10.1016/j.kint.2021.04.021

The thiazide-sensitive sodium-chloride-cotransporter (NCC) in the kidney distal convoluted tubule (DCT) plays an essential role in sodium and potassium homeostasis. Here, we demonstrate that NCC activity is increased by the β2-adrenoceptor agonist s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec93dd6d32f835cd70d945d87a1a1c8e
https://doi.org/10.1016/j.kint.2021.04.021

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Collecting system–specific deletion of Kcnj10 predisposes for thiazide- and low-potassium diet–induced hypokalemia

Autor: Eszter Banki, Maria Weigert, Johannes Loffing, Twinkle Vohra, Anna-Lena Forst, Agnieszka Wengi, David Penton, Sascha Bandulik, Richard Warth

Publikováno v: Kidney International. 97:1208-1218

The basolateral potassium channel KCNJ10 (Kir4.1), is expressed in the renal distal convoluted tubule and controls the activity of the thiazide-sensitive sodium chloride cotransporter. Loss-of-function mutations of KCNJ10 cause EAST/SeSAME syndrome w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ca00a7ad53c0fe23aff6aaf89e894d7
https://doi.org/10.1016/j.kint.2019.12.016

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Spatial proteomics finds CD155 and Endophilin-A1 as mediators of growth and invasion in medulloblastoma

Autor: Charles, Capdeville, Linda, Russo, David, Penton, Jessica, Migliavacca, Milica, Zecevic, Alexandre, Gries, Stephan Cf, Neuhauss, Michael A, Grotzer, Martin, Baumgartner

Publikováno v: Life science alliance. 5(6)

The composition of the plasma membrane (PM)-associated proteome of tumor cells determines cell-cell and cell-matrix interactions and the response to environmental cues. Whether the PM-associated proteome impacts the phenotype of Medulloblastoma (MB)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::01db57260f3f9b32c0965c1483602294
https://pubmed.ncbi.nlm.nih.gov/35296518

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