Zobrazeno 1 - 10
of 453
pro vyhledávání: '"David, O'Hagan"'
Publikováno v:
IUCrData, Vol 8, Iss 4, p x230300 (2023)
A new isoxazole-based iodonoium salt, C13H13INO5+·C2F3O2−, has been synthesized and structurally characterized. In the crystal, ions are linked by short I...O contacts to form a neutral tetra-ion aggregate. These combine with C—H...F and C—H..
Externí odkaz:
https://doaj.org/article/afac430608a446a7a7d35be5a5c586ff
Autor:
Tiia Kittilä, Patricia Calero, Folmer Fredslund, Phillip T. Lowe, David Tezé, Manuel Nieto‐Domínguez, David O’Hagan, Pablo I. Nikel, Ditte H. Welner
Publikováno v:
Microbial Biotechnology, Vol 15, Iss 5, Pp 1622-1632 (2022)
Summary The fluorinase enzyme represents the only biological mechanism capable of forming stable C–F bonds characterized in nature thus far, offering a biotechnological route to the biosynthesis of value‐added organofluorines. The fluorinase is k
Externí odkaz:
https://doaj.org/article/30a605b318914efbbf5a7a77aa635e6c
Autor:
Patricia Calero, Daniel C. Volke, Phillip T. Lowe, Charlotte H. Gotfredsen, David O’Hagan, Pablo I. Nikel
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Addition of fluorine to organic structures is a unique strategy for tuning molecular properties, but approaches to integrate fluorometabolites into the biochemistry of living cells are scarce. Here, the authors develop a fluoride-responsive genetic c
Externí odkaz:
https://doaj.org/article/1a6013c572344c6f92fbaa1ff47e21f1
Autor:
Zeguo Fang, Nawaf Al-Maharik, Peer Kirsch, Matthias Bremer, Alexandra M. Z. Slawin, David O’Hagan
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 16, Iss 1, Pp 674-680 (2020)
This paper describes the synthesis of a series of organic liquid crystals (LCs) containing selectively fluorinated cyclopropanes at their termini. The syntheses used difluorocarbene additions to olefin precursors, an approach which proved straightfor
Externí odkaz:
https://doaj.org/article/f688a8e36afa4f89b9f69cf178810115
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 15, Iss 1, Pp 1441-1447 (2019)
We report the metabolism of the recently introduced α,α-difluoroethyl thioether motif to explore further its potential as a substituent for bioactives discovery chemistry. Incubation of two aryl–SCF2CH3 ethers with the model yeast organism Cunnin
Externí odkaz:
https://doaj.org/article/f472c82d982e40fa80b649abe58c69f7
Publikováno v:
The Journal of Physical Chemistry A. 127:724-728
Autor:
Phillip T. Lowe, David O’Hagan
Publikováno v:
Chemical Society Reviews. 52:248-276
The history and development of 4'-fluoro-nucleosides is discussed in this review. This is a class of nucleosides which have their origin in the discovery of the rare fluorine containing natural product nucleocidin. Nucleocidin contains a fluorine ato
Autor:
Neil S. Keddie, Pier Alexandre Champagne, Justine Desroches, Jean-François Paquin, David O'Hagan
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 14, Iss 1, Pp 106-113 (2018)
In recent years, the highly polar C–F bond has been utilised in activation chemistry despite its low reactivity to traditional nucleophiles, when compared to other C–X halogen bonds. Paquin’s group has reported extensive studies on the C–F ac
Externí odkaz:
https://doaj.org/article/973a1210e2264aaebefcc969cde13578
Autor:
David O’Hagan
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 17, Iss 1, Pp 737-738 (2021)
Externí odkaz:
https://doaj.org/article/ea56a1e1ef7e41f9994ee156ed8e4af5
Synthetic routes following a sequential MacMillan organocatalytic asymmetric a-fluorination protocol for aldehydes and then reductive amination, has allowed ready access to bioactive b-fluoroamines. The approach is demonstrated with a short synthesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6e672c4b760cfa5c292bbe00f42d1e1
https://doi.org/10.21203/rs.3.rs-2937250/v1
https://doi.org/10.21203/rs.3.rs-2937250/v1