Zobrazeno 1 - 10
of 183
pro vyhledávání: '"David, Nemazee"'
Autor:
Shridhar Bale, Lifei Yang, Mehrdad Alirezaei, Richard Wilson, Takayuki Ota, Esmeralda D. Doyle, Christopher A. Cottrell, Javier Guenaga, Karen Tran, Wenjuan Li, Leonidas Stamatatos, David Nemazee, Andrew B. Ward, Richard T. Wyatt
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
An effective HIV vaccine likely requires the elicitation of neutralizing antibodies (NAbs) against multiple HIV-1 clades. The recently developed cleavage-independent native flexibly linked (NFL) envelope (Env) trimers exhibit well-ordered conformatio
Externí odkaz:
https://doaj.org/article/426af3d593f04edcb1ecad43361ff2ec
Autor:
Jonathan Hurtado, Claudia Flynn, Jeong Hyun Lee, Eugenia C. Salcedo, Christopher A. Cottrell, Patrick D. Skog, Dennis R. Burton, David Nemazee, William R. Schief, Elise Landais, Devin Sok, Bryan Briney
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2023)
The ability to efficiently isolate antigen-specific B cells in high throughput will greatly accelerate the discovery of therapeutic monoclonal antibodies (mAbs) and catalyze rational vaccine development. Traditional mAb discovery is a costly and labo
Externí odkaz:
https://doaj.org/article/872e188662cf45d480b2e529faf46daf
Autor:
Fortunato Ferrara, M. Frank Erasmus, Sara D’Angelo, Camila Leal-Lopes, André A. Teixeira, Alok Choudhary, William Honnen, David Calianese, Deli Huang, Linghan Peng, James E. Voss, David Nemazee, Dennis R. Burton, Abraham Pinter, Andrew R. M. Bradbury
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
The most potent neutralizing antibodies are typically generated from convalescent patients and immunized animals. Here, the authors show it is possible to generate highly potent human neutralizing antibodies against the SARS-CoV-2 spike protein direc
Externí odkaz:
https://doaj.org/article/70d41bbd50c147b58d9359405fbd65f0
Autor:
Amanda L. Gavin, Deli Huang, Tanya R. Blane, Therese C. Thinnes, Yusuke Murakami, Ryutaro Fukui, Kensuke Miyake, David Nemazee
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Loss of function polymorphisms of phospholipase D3 and D4 are associated with inflammatory diseases and their function is unclear. Here the authors show that PLD3/4 function as RNAses and deletion of these proteins in mice leads to accumulation of ss
Externí odkaz:
https://doaj.org/article/9f47727d2fa540ce8664019ff424400c
Autor:
Fangzhu Zhao, Celina Keating, Gabriel Ozorowski, Namir Shaabani, Irene M. Francino-Urdaniz, Shawn Barman, Oliver Limbo, Alison Burns, Panpan Zhou, Michael J. Ricciardi, Jordan Woehl, Quoc Tran, Hannah L. Turner, Linghang Peng, Deli Huang, David Nemazee, Raiees Andrabi, Devin Sok, John R. Teijaro, Timothy A. Whitehead, Andrew B. Ward, Dennis R. Burton, Joseph G. Jardine
Publikováno v:
iScience, Vol 25, Iss 9, Pp 104914- (2022)
Summary: The rapid spread of SARS-CoV-2 variants poses a constant threat of escape from monoclonal antibody and vaccine countermeasures. Mutations in the ACE2 receptor binding site on the surface S protein have been shown to disrupt antibody binding
Externí odkaz:
https://doaj.org/article/248cba15fce54b88a8bce360835a4e07
Autor:
Ge Song, Wan-ting He, Sean Callaghan, Fabio Anzanello, Deli Huang, James Ricketts, Jonathan L. Torres, Nathan Beutler, Linghang Peng, Sirena Vargas, Jon Cassell, Mara Parren, Linlin Yang, Caroline Ignacio, Davey M. Smith, James E. Voss, David Nemazee, Andrew B. Ward, Thomas Rogers, Dennis R. Burton, Raiees Andrabi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Pre-existing immune responses between antigenically related viruses can influence responses in viral infections or vaccinations. Here the authors assess and characterize the presence of antibody and memory B cell populations specific to SARS-CoV2 and
Externí odkaz:
https://doaj.org/article/375cf7fbbde74db9912e52d557b7a046
Autor:
Deli Huang, Jenny Tuyet Tran, Alex Olson, Thomas Vollbrecht, Mary Tenuta, Mariia V. Guryleva, Roberta P. Fuller, Torben Schiffner, Justin R. Abadejos, Lauren Couvrette, Tanya R. Blane, Karen Saye, Wenjuan Li, Elise Landais, Alicia Gonzalez-Martin, William Schief, Ben Murrell, Dennis R. Burton, David Nemazee, James E. Voss
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
A vaccine to generate durable HIV broadly neutralizing antibodies (bnAb) from engineered B cells holds promise as an HIV functional cure. Here, the authors show that CRISPR/Cas-modified B cells expressing bnAbs as functional antigen receptors can be
Externí odkaz:
https://doaj.org/article/8f0e41a577a24e6390766e0efaf6153c
Autor:
Nicholas C Wu, Meng Yuan, Sandhya Bangaru, Deli Huang, Xueyong Zhu, Chang-Chun D Lee, Hannah L Turner, Linghang Peng, Linlin Yang, Dennis R Burton, David Nemazee, Andrew B Ward, Ian A Wilson
Publikováno v:
PLoS Pathogens, Vol 16, Iss 12, p e1009089 (2020)
Epitopes that are conserved among SARS-like coronaviruses are attractive targets for design of cross-reactive vaccines and therapeutics. CR3022 is a SARS-CoV neutralizing antibody to a highly conserved epitope on the receptor binding domain (RBD) on
Externí odkaz:
https://doaj.org/article/7a26590600364280b6b438a6bfd964df
Autor:
Fortunato Ferrara, M. Frank Erasmus, Sara D’Angelo, Camila Leal-Lopes, André A. Teixeira, Alok Choudhary, William Honnen, David Calianese, Deli Huang, Linghan Peng, James E. Voss, David Nemazee, Dennis R. Burton, Abraham Pinter, Andrew R. M. Bradbury
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/475a050a652e4d089622738cd5f93eca
Autor:
Aleksandar Antanasijevic, George Ueda, Philip J M Brouwer, Jeffrey Copps, Deli Huang, Joel D Allen, Christopher A Cottrell, Anila Yasmeen, Leigh M Sewall, Ilja Bontjer, Thomas J Ketas, Hannah L Turner, Zachary T Berndsen, David C Montefiori, Per Johan Klasse, Max Crispin, David Nemazee, John P Moore, Rogier W Sanders, Neil P King, David Baker, Andrew B Ward
Publikováno v:
PLoS Pathogens, Vol 16, Iss 8, p e1008665 (2020)
Two-component, self-assembling nanoparticles represent a versatile platform for multivalent presentation of viral antigens. Computational design of protein nanoparticles with differing sizes and geometries enables combination with antigens of choice
Externí odkaz:
https://doaj.org/article/bef6f6ca42a24283ba89afa6be5d0385