Zobrazeno 1 - 10
of 60
pro vyhledávání: '"David, Marciano"'
Autor:
Marissa D. Pokharel, Alejandro Garcia-Flores, David Marciano, Maria C. Franco, Jeffrey R. Fineman, Saurabh Aggarwal, Ting Wang, Stephen M. Black
Publikováno v:
Redox Biology, Vol 70, Iss , Pp 103049- (2024)
Once thought of in terms of bioenergetics, mitochondria are now widely accepted as both the orchestrator of cellular health and the gatekeeper of cell death. The pulmonary disease field has performed extensive efforts to explore the role of mitochond
Externí odkaz:
https://doaj.org/article/ca0f8236e2604227a1b3d514218b84a6
Autor:
Qing Liu, Haodi Wu, Zhana Duren, Chao Jiang, Kevin Van Bortle, Mingtao Zhao, Hongchao Guo, Chenchen Zhu, Qing-Jun Luo, Bingqing Zhao, Jun Liu, David Marciano, Joshua Gruber, Andrew Lipchik, Anil Narasimha, Nathaniel Watson, Ming-Shian Tsai, Takaaki Furihata, Lei Tian, Eric Wei, Yingxin Li, Lars Steinmetz, Wing H. Wong, Mark Kay, Joseph Wu, Michael Snyder
Tyrosine kinase inhibitors (TKIs) have been widely used for cancer chemotherapy, but they also cause cardiotoxicities in cancer patients. In this study, we used human stem cells as an in-vitro system to interrogate the mechanisms underlying drug-indu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f09cc6a6fed2020a7b9d59cd90c40d5e
https://doi.org/10.21203/rs.3.rs-2343653/v1
https://doi.org/10.21203/rs.3.rs-2343653/v1
Autor:
Marlene Rabinovitch, Toshie Saito, Maria Eugenia Ariza, Shoichiro Otsuki, Jan-Renier A. J. Moonen, Lingli Wang, Aiqin Cao, David Marciano, Dan Li, Shalina Taylor, Rebecca L. Harper
Publikováno v:
JCI Insight
We previously reported heightened expression of the human endogenous retroviral protein HERV-K deoxyuridine triphosphate nucleotidohydrolase (dUTPase) in circulating monocytes and pulmonary arterial (PA) adventitial macrophages of patients with PA hy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91a39ba2d584fa0c65fc5a6e2161a459
http://europepmc.org/articles/PMC8410063
http://europepmc.org/articles/PMC8410063
Autor:
Jan-Renier A. J. Moonen, Kévin Contrepois, Lingli Wang, David Marciano, Joseph C. Wu, Shoichiro Otsuki, Minyi Shi, Marlene Rabinovitch, Ning-Yi Shao, Michael Snyder, Dan Li, Tiffany Nguyen, Elaine Yan, Caiyun G. Li, Zhixin Zhao
Publikováno v:
Circulation
Background: Metabolic alterations provide substrates that influence chromatin structure to regulate gene expression that determines cell function in health and disease. Heightened proliferation of smooth muscle cells (SMC) leading to the formation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fa8afc1ef5cf166065c15b936283151
https://europepmc.org/articles/PMC8289565/
https://europepmc.org/articles/PMC8289565/
Autor:
Kazuya Miyagawa, Michael Snyder, A. A. Roger Thompson, Jan-Renier A. J. Moonen, Bérénice A. Benayoun, Mark R. Nicolls, Shoichiro Otsuki, David Marciano, Andrew Hsi, Sarasa Isobe, Mehmet Ozgun Ozen, Stavros Melemenidis, Kévin Contrepois, Lingli Wang, Shalina Taylor, Mingxia Gu, Aiqin Cao, Maria-Eugenia Ariza, Patricia A. del Rosario, Jordan Kaplan, Roham T. Zamanian, Tsutomu Shinohara, Marlene Rabinovitch, Francois Haddad, Utkan Demirci, Andrew J. Sweatt, Lihua Jiang
Neutrophil elastase (NE) is implicated in pulmonary arterial hypertension (PAH) but the role of neutrophils in the pathogenesis of PAH is unclear. Here we show that neutrophils from PAH vs. control subjects produce and release increased NE associated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::abe21356e6f0eab245d47cefd60466cd
https://doi.org/10.1101/2021.01.08.426001
https://doi.org/10.1101/2021.01.08.426001
Autor:
Isabel Diebold, James D. Chappell, Jan K. Hennigs, Marlene Rabinovitch, Pin-I Chen, Aiqin Cao, Matthew Bill, Minyi Shi, Rebecca L. Harper, Caiyun G. Li, Jan-Renier A. J. Moonen, Kazuya Miyagawa, Michael Snyder, David Marciano, Matthew V. Elliott, Julia Mienert, Matthew Roughley, Jakob Körbelin, Lingli Wang
Publikováno v:
Circ Res
Rationale: In pulmonary arterial hypertension (PAH), endothelial dysfunction and obliterative vascular disease are associated with DNA damage and impaired signaling of BMPR2 (bone morphogenetic protein type 2 receptor) via two downstream transcriptio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c0f99865bb2ae57c6b8129ecefee30a
https://pubmed.ncbi.nlm.nih.gov/33322916
https://pubmed.ncbi.nlm.nih.gov/33322916
Autor:
Wing Hung Wong, Hongchao Guo, Chenchen Zhu, Ming-Shian Tsai, Takaaki Furihata, Nathaniel Watson, Chao Jiang, Lei Tian, Andrew M. Lipchik, Joshua J. Gruber, Michael Snyder, Kevin Van Bortle, Haodi Wu, David Marciano, Yingxin Li, Eric X Wei, Joseph C. Wu, Zhana Duren, Qing-Jun Luo, Brittany Lee-McMullen, Mark A. Kay, Bingqing Zhao, Lars M. Steinmetz, Ming-Tao Zhao, Anil Narasimha, Jun Liu, Qing Liu
SUMMARYMaternal drug exposure during pregnancy increases the risks of developmental cardiotoxicity, leading to congenital heart defects (CHDs). In this study, we used human stem cells as anin-vitrosystem to interrogate the mechanisms underlying drug-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d8fa29c03d850439b80ce5ab0d56df6
Publikováno v:
Journal de Neuroradiologie / Journal of Neuroradiology
Journal de Neuroradiologie / Journal of Neuroradiology, Elsevier Masson, 2017, 44 (1), pp.44-51. ⟨10.1016/j.neurad.2016.10.004⟩
Journal de Neuroradiologie / Journal of Neuroradiology, Elsevier Masson, 2017, 44 (1), pp.44-51. ⟨10.1016/j.neurad.2016.10.004⟩
International audience; Background and purposeData about non-invasive follow-up of aneurysm after stent-assisted coiling is scarce. We aimed to compare time-of-flight (TOF) magnetic resonance angiography (MRA) (3D-TOF-MRA) and contrast-enhanced MRA (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c4c664f727bfaa6617c27ba9f3e9443
https://doi.org/10.1016/j.neurad.2016.10.004
https://doi.org/10.1016/j.neurad.2016.10.004
Autor:
Michael Snyder, David Marciano
Publikováno v:
High-Throughput Metabolomics ISBN: 9781493992355
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1077218577e4f656438e6a3939ab7bf2
https://doi.org/10.1007/978-1-4939-9236-2_27
https://doi.org/10.1007/978-1-4939-9236-2_27
Autor:
Jie Zheng, Cesar A. Corzo, Theodore M. Kamenecka, Beata Lecka-Czernik, Patrick R. Griffin, F.N. Tausif, Lance A. Stechschulte, John B. Bruning, David Marciano, Alice Asteian, Z.C. Rotter, Piotr J. Czernik, Clifford J. Rosen
Publikováno v:
EBioMedicine
EBioMedicine, Vol 10, Iss C, Pp 174-184 (2016)
EBioMedicine, Vol 10, Iss C, Pp 174-184 (2016)
The peroxisome proliferator-activated receptor gamma (PPARγ) regulates osteoblast and osteoclast differentiation, and is the molecular target of thiazolidinediones (TZDs), insulin sensitizers that enhance glucose utilization and adipocyte differenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6f3a885fb852b1c2cb65704621f32de
http://europepmc.org/articles/PMC5006645
http://europepmc.org/articles/PMC5006645