Zobrazeno 1 - 10
of 59
pro vyhledávání: '"David, Malinak"'
Autor:
Xueqin Huang, Li You, Eugenie Nepovimova, Miroslav Psotka, David Malinak, Marian Valko, Ladislav Sivak, Jan Korabecny, Zbynek Heger, Vojtech Adam, Qinghua Wu, Kamil Kuca
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
AbstractPhosphoinositide 3-kinases (PI3K) and phosphoinositide 3-kinase-related protein kinases (PIKK) are two structurally related families of kinases that play vital roles in cell growth and DNA damage repair. Dysfunction of PIKK members and aberra
Externí odkaz:
https://doaj.org/article/2625c42c0d07439f92419713efaf92ad
Autor:
Eliska Prchalova, Martina Sukupova, David Malinak, Rudolf Andrys, Ladislav Sivak, Vladimir Pekarik, Adam Skarka, Jana Svobodova, Lukas Prchal, Lukas Fresser, Zbynek Heger, Kamil Musilek
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 167, Iss , Pp 115490- (2023)
The BODIPY-labelled oxime reactivator was prepared and used to study its biodistribution into central nervous system. The newly synthesized oxime was found to be weak inhibitor of acetylcholinesterase and strong inhibitor of butyrylcholinesterase. It
Externí odkaz:
https://doaj.org/article/e1552502a55f468193830aae36c102b1
Autor:
Zuzana Kohoutova, David Malinak, Rudolf Andrys, Jana Svobodova, Miroslav Psotka, Monika Schmidt, Lukas Prchal, Kamil Musilek
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 760-767 (2022)
The organophosphorus antidotes, so-called oximes, are able to restore the enzymatic function of acetylcholinesterase (AChE) or butyrylcholinesterase (BChE) via cleavage of organophosphate from the active site of the phosphylated enzyme. In this work,
Externí odkaz:
https://doaj.org/article/d7105037e8584f718109d172295dd89d
Autor:
Hyun Myung Lee, Rudolf Andrys, Jakub Jonczyk, Kyuneun Kim, Avinash G. Vishakantegowda, David Malinak, Adam Skarka, Monika Schmidt, Michaela Vaskova, Kamil Latka, Marek Bajda, Young-Sik Jung, Barbara Malawska, Kamil Musilek
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 437-449 (2021)
The pyridinium-2-carbaldoximes with quinolinium carboxamide moiety were designed and synthesised as cholinesterase reactivators. The prepared compounds showed intermediate-to-high inhibition of both cholinesterases when compared to standard oximes. T
Externí odkaz:
https://doaj.org/article/4f1eaa9e04f94ca384b62f9d55e4a656
Autor:
Patrik Oleksak, Miroslav Psotka, Marketa Vancurova, Olena Sapega, Jana Bieblova, Milan Reinis, David Rysanek, Romana Mikyskova, Katarina Chalupova, David Malinak, Jana Svobodova, Rudolf Andrys, Helena Rehulkova, Vojtech Skopek, Pham Ngoc Lam, Jiri Bartek, Zdenek Hodny, Kamil Musilek
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 410-424 (2021)
Twelve novel analogs of STAT3 inhibitor BP-1-102 were designed and synthesised with the aim to modify hydrophobic fragments of the molecules that are important for interaction with the STAT3 SH2 domain. The cytotoxic activity of the reference and nov
Externí odkaz:
https://doaj.org/article/cfac0c0e4320428ab38cfae14e7c28f8
Autor:
David Malinak, Rafael Dolezal, Vendula Hepnarova, Miroslava Hozova, Rudolf Andrys, Petr Bzonek, Veronika Racakova, Jan Korabecny, Lukas Gorecki, Eva Mezeiova, Miroslav Psotka, Daniel Jun, Kamil Kuca, Kamil Musilek
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 478-488 (2020)
The series of symmetrical and unsymmetrical isoquinolinium-5-carbaldoximes was designed and prepared for cholinesterase reactivation purposes. The novel compounds were evaluated for intrinsic acetylcholinesterase (AChE) or butyrylcholinesterase (BChE
Externí odkaz:
https://doaj.org/article/4eaa3b83e7db43c89b59bdfb119cb77b
Autor:
Eva Mezeiova, Katarina Spilovska, Eugenie Nepovimova, Lukas Gorecki, Ondrej Soukup, Rafael Dolezal, David Malinak, Jana Janockova, Daniel Jun, Kamil Kuca, Jan Korabecny
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 583-606 (2018)
Alzheimer’s disease is debilitating neurodegenerative disorder in the elderly. Current therapy relies on administration of acetylcholinesterase inhibitors (AChEIs) -donepezil, rivastigmine, galantamine, and N-methyl-d-aspartate receptor antagonist
Externí odkaz:
https://doaj.org/article/f4d7abc278ba4229b488013ba972aa08
Autor:
Kalodiah G. Toma, Irene Masini, Garrick Johnson, Paramveer Birring, Rhaya Alkafaji, Carter Do, Christina L. Cui, David Malinak, Ellen Beck
Publikováno v:
Journal of Hunger & Environmental Nutrition. :1-11
Autor:
Sunny Smith, David Malinak, Jinnie Chang, Maria Perez, Sandra Perez, Erica Settlecowski, Timothy Rodriggs, Ming Hsu, Alexandra Abrew, Sofia Aedo
Publikováno v:
Preventive Medicine Reports, Vol 5, Iss C, Pp 134-139 (2017)
Food insecurity is associated with many poor health outcomes yet is not routinely addressed in clinical settings. The purpose of this study was to implement a food insecurity screening and referral program in Student-run Free Clinics (SRFC) and to do
Externí odkaz:
https://doaj.org/article/72e0189e5c7940f79a7690c96c262398
Autor:
Jan Korabecny, Martin Andrs, Eugenie Nepovimova, Rafael Dolezal, Katerina Babkova, Anna Horova, David Malinak, Eva Mezeiova, Lukas Gorecki, Vendula Sepsova, Martina Hrabinova, Ondrej Soukup, Daniel Jun, Kamil Kuca
Publikováno v:
Molecules, Vol 20, Iss 12, Pp 22084-22101 (2015)
Alzheimer’s disease (AD) is a debilitating progressive neurodegenerative disorder that ultimately leads to the patient’s death. Despite the fact that novel pharmacological approaches endeavoring to block the neurodegenerative process are still em
Externí odkaz:
https://doaj.org/article/0c1bebafcb9c40c69dde513c28fd02e1