Investigating the relationship between thalamic iron concentration and disease severity in secondary progressive multiple sclerosis using quantitative susceptibility mapping: Cross-sectional analysis from the MS-STAT2 randomised controlled trial

Autor: Thomas Williams, Nevin John, Alberto Calvi, Alessia Bianchi, Floriana De Angelis, Anisha Doshi, Sarah Wright, Madiha Shatila, Marios C. Yiannakas, Fatima Chowdhury, Jon Stutters, Antonio Ricciardi, Ferran Prados, David MacManus, Francesco Grussu, Anita Karsa, Becky Samson, Marco Battiston, Claudia A.M. Gandini Wheeler-Kingshott, Karin Shmueli, Olga Ciccarelli, Frederik Barkhof, Jeremy Chataway, Wallace Brownlee, Claudia AM. Gandini Wheeler-Kingshott, Jonathan Stutters, Ferran Prados Carrasco, Marios Yiannakas, Megan Wynne, Marie Braisher, James Blackstone, Leanne Hockey, Josephine Parker, Jennifer Flight, Chris Frost, Jennifer Nicholas, Stuart Nixon, Judy Beveridge

Publikováno v: Neuroimage: Reports, Vol 4, Iss 3, Pp 100216- (2024)

Background: Deep grey matter pathology is a key driver of disability worsening in people with multiple sclerosis. Quantitative susceptibility mapping (QSM) is an advanced magnetic resonance imaging (MRI) technique which quantifies local magnetic susc

Externí odkaz: https://doaj.org/article/a5f0c83cc2dc4adf9dbc117e4d8f1ca0

Amiloride, fluoxetine or riluzole to reduce brain volume loss in secondary progressive multiple sclerosis: the MS-SMART four-arm RCT

Autor: Floriana De Angelis, Peter Connick, Richard A Parker, Domenico Plantone, Anisha Doshi, Nevin John, Jonathan Stutters, David MacManus, Ferran Prados, Ian Marshall, Bhavana Solanky, Rebecca S Samson, Frederik Barkhof, Sebastien Ourselin, Marie Braisher, Moira Ross, Gina Cranswick, Sue H Pavitt, Sharmilee Gnanapavan, Gavin Giovannoni, Claudia AM Gandini Wheeler-Kingshott, Clive Hawkins, Basil Sharrack, Roger Bastow, Christopher J Weir, Nigel Stallard, Siddharthan Chandran, Jeremy Chataway

Publikováno v: Efficacy and Mechanism Evaluation, Vol 7, Iss 3 (2020)

Background: Neuroprotective drugs are needed to slow or prevent neurodegeneration and disability accrual in secondary progressive multiple sclerosis. Amiloride, fluoxetine and riluzole are repurposed drugs with potential neuroprotective effects. Obje

Externí odkaz: https://doaj.org/article/1bf07b99cbbe44a4b0f26520d86e3ec8

A wind tunnel rig to study the external fan cowl separation experienced by compact nacelles in windmilling scenarios

Autor: Sabnis, Kshitij, Boscagli, Luca, Swarthout, Avery, Tejero Embuena, Fernando, Babinsky, Holger, David, MacManus, Sheaf, Christopher

Ultra high-bypass ratio aircraft engines adopt slim fan cowl profiles which are sensitive to separation on their external surfaces under diversion windmilling conditions, when engine shutdown occurs during cruise. A two-dimensional wind tunnel rig is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edb106198d3bceec55bf72168986f702
https://dspace.lib.cranfield.ac.uk/handle/1826/19260

Design of a high-speed intake distortion simulator for propulsion integration research

Autor: Matteo Migliorini, Artur Szymanski, Pavlos K. Zachos, David MacManus, Peter G. Martin

Publikováno v: AIAA SCITECH 2023 Forum.

High levels of inlet flow distortion can be a critical aspect in supersonic air induction systems due to the complex spatial nature and notable temporal unsteadiness. This can affect the operability and performance of the propulsion system. Simulatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c135044fdb7f7d97f155f4ca87724779
https://doi.org/10.2514/6.2023-2356

Intimate Partner Violence and Abuse:A Qualitative Exploration of UK Military Personnel and Civilian Partner Experiences

Autor: Anna Taylor, David MacManus, Rachael Gribble, Nicola Fear, Deirdre MacManus, Louise Howard, Filipa Alves-Costa, Rebecca Lane

Publikováno v: Lane, R, Gribble, R, Alves-Costa, F, Taylor, A, Howard, L M, Fear, N T & MacManus, D 2022, ' Intimate Partner Violence and Abuse : A Qualitative Exploration of UK Military Personnel and Civilian Partner Experiences ', JOURNAL OF FAMILY VIOLENCE . https://doi.org/10.1007/s10896-022-00446-x

Purpose The prevalence of Intimate Partner Violence and Abuse (IPVA) perpetration and victimisation has been found to be higher in serving and ex-serving military samples compared to civilians. Despite this, there is a lack of qualitative research ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f70c5a6f104fb18d5c6619a9cf92eae9
https://kclpure.kcl.ac.uk/en/publications/b342cd5a-1cfb-42f0-9b94-9571c303ce0b